A Systematic Review of the Effects of Different Types of Therapeutic Exercise on Physiologic and Functional Measurements in Patients with HIV/AIDS

Overview

Journal Clinics (Sao Paulo)

Publisher Elsevier

Specialty General Medicine

Date 2013 Sep 17

PMID 24037014

Citations 35

Authors

Mansueto Gomes-Neto

Cristiano Sena Conceicao

Vitor Oliveira Carvalho

Carlos Brites

Affiliations

Soon will be listed here.

Abstract

Several studies have reported the benefits of exercise training for adults with HIV, although there is no consensus regarding the most efficient modalities. The aim of this study was to determine the effects of different types of exercise on physiologic and functional measurements in patients with HIV using a systematic strategy for searching randomized controlled trials. The sources used in this review were the Cochrane Library, EMBASE, MEDLINE, and PEDro from 1950 to August 2012. We selected randomized controlled trials examining the effects of exercise on body composition, muscle strength, aerobic capacity, and/or quality of life in adults with HIV. Two independent reviewers screened the abstracts using the Cochrane Collaboration's protocol. The PEDro score was used to evaluate methodological quality. In total, 29 studies fulfilled the inclusion criteria. Individual studies suggested that exercise training contributed to improvement of physiologic and functional parameters, but that the gains were specific to the type of exercise performed. Resistance exercise training improved outcomes related to body composition and muscle strength, with little impact on quality of life. Aerobic exercise training improved body composition and aerobic capacity. Concurrent training produced significant gains in all outcomes evaluated, although moderate intensity and a long duration were necessary. We concluded that exercise training was shown to be a safe and beneficial intervention in the treatment of patients with HIV.

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References

OBrien K, Nixon S, Glazier R, Tynan A . Progressive resistive exercise interventions for adults living with HIV/AIDS. Cochrane Database Syst Rev. 2004; (4):CD004248. DOI: 10.1002/14651858.CD004248.pub2. View

Galantino M, Shepard K, Krafft L, Laperriere A, DuCette J, Sorbello A . The effect of group aerobic exercise and t'ai chi on functional outcomes and quality of life for persons living with acquired immunodeficiency syndrome. J Altern Complement Med. 2006; 11(6):1085-92. DOI: 10.1089/acm.2005.11.1085. View

Shevitz A, Wilson I, McDermott A, Spiegelman D, Skinner S, Antonsson K . A comparison of the clinical and cost-effectiveness of 3 intervention strategies for AIDS wasting. J Acquir Immune Defic Syndr. 2005; 38(4):399-406. DOI: 10.1097/01.qai.0000152647.89008.2b. View

Sattler F, Jaque S, Schroeder E, Olson C, Dube M, Martinez C . Effects of pharmacological doses of nandrolone decanoate and progressive resistance training in immunodeficient patients infected with human immunodeficiency virus. J Clin Endocrinol Metab. 1999; 84(4):1268-76. DOI: 10.1210/jcem.84.4.5610. View

Mutimura E, Crowther N, Cade T, Yarasheski K, Stewart A . Exercise training reduces central adiposity and improves metabolic indices in HAART-treated HIV-positive subjects in Rwanda: a randomized controlled trial. AIDS Res Hum Retroviruses. 2008; 24(1):15-23. PMC: 3936606. DOI: 10.1089/aid.2007.0023. View

Rigsby L, Dishman R, Jackson A, Maclean G, Raven P . Effects of exercise training on men seropositive for the human immunodeficiency virus-1. Med Sci Sports Exerc. 1992; 24(1):6-12. View

AGIN D, Gallagher D, Wang J, Heymsfield S, Pierson Jr R, Kotler D . Effects of whey protein and resistance exercise on body cell mass, muscle strength, and quality of life in women with HIV. AIDS. 2001; 15(18):2431-40. DOI: 10.1097/00002030-200112070-00011. View

Spence D, Galantino M, Mossberg K, Zimmerman S . Progressive resistance exercise: effect on muscle function and anthropometry of a select AIDS population. Arch Phys Med Rehabil. 1990; 71(9):644-8. View

Mazzetti S, Kraemer W, Volek J, Duncan N, Ratamess N, Gomez A . The influence of direct supervision of resistance training on strength performance. Med Sci Sports Exerc. 2000; 32(6):1175-84. DOI: 10.1097/00005768-200006000-00023. View

10.

Terry L, Sprinz E, Stein R, Medeiros N, Oliveira J, Ribeiro J . Exercise training in HIV-1-infected individuals with dyslipidemia and lipodystrophy. Med Sci Sports Exerc. 2006; 38(3):411-7. DOI: 10.1249/01.mss.0000191347.73848.80. View

11.

Terry L, Sprinz E, Ribeiro J . Moderate and high intensity exercise training in HIV-1 seropositive individuals: a randomized trial. Int J Sports Med. 1999; 20(2):142-6. DOI: 10.1055/s-2007-971108. View

12.

Perez-Moreno F, Camara-Sanchez M, Tremblay J, Riera-Rubio V, Gil-Paisan L, Lucia A . Benefits of exercise training in Spanish prison inmates. Int J Sports Med. 2007; 28(12):1046-52. DOI: 10.1055/s-2007-965129. View

13.

Campos G, Luecke T, Wendeln H, Toma K, Hagerman F, Murray T . Muscular adaptations in response to three different resistance-training regimens: specificity of repetition maximum training zones. Eur J Appl Physiol. 2002; 88(1-2):50-60. DOI: 10.1007/s00421-002-0681-6. View

14.

Hand G, Phillips K, Dudgeon W, Lyerly G, Durstine J, Burgess S . Moderate intensity exercise training reverses functional aerobic impairment in HIV-infected individuals. AIDS Care. 2008; 20(9):1066-74. DOI: 10.1080/09540120701796900. View

15.

Neidig J, Smith B, Brashers D . Aerobic exercise training for depressive symptom management in adults living with HIV infection. J Assoc Nurses AIDS Care. 2003; 14(2):30-40. DOI: 10.1177/1055329002250992. View

16.

Perna F, Laperriere A, Klimas N, Ironson G, Perry A, Pavone J . Cardiopulmonary and CD4 cell changes in response to exercise training in early symptomatic HIV infection. Med Sci Sports Exerc. 1999; 31(7):973-9. DOI: 10.1097/00005768-199907000-00009. View

17.

Smith B, Neidig J, Nickel J, Mitchell G, Para M, Fass R . Aerobic exercise: effects on parameters related to fatigue, dyspnea, weight and body composition in HIV-infected adults. AIDS. 2001; 15(6):693-701. DOI: 10.1097/00002030-200104130-00004. View

18.

Garber C, Blissmer B, Deschenes M, Franklin B, LaMonte M, Lee I . American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011; 43(7):1334-59. DOI: 10.1249/MSS.0b013e318213fefb. View

19.

Mutimura E, Stewart A, Crowther N, Yarasheski K, Cade W . The effects of exercise training on quality of life in HAART-treated HIV-positive Rwandan subjects with body fat redistribution. Qual Life Res. 2008; 17(3):377-85. PMC: 3167195. DOI: 10.1007/s11136-008-9319-4. View

20.

Fillipas S, Oldmeadow L, Bailey M, Cherry C . A six-month, supervised, aerobic and resistance exercise program improves self-efficacy in people with human immunodeficiency virus: a randomised controlled trial. Aust J Physiother. 2006; 52(3):185-90. DOI: 10.1016/s0004-9514(06)70027-7. View