Differences in Microbicidal Activities of Human Macrophages Against Toxoplasma Gondii and Trypanosoma Cruzi

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1990 Jan 1

PMID 2403533

Citations 3

Authors

D M Israelski

F G Araujo

J S Wachtel

L HEINRICHS

J S Remington

Affiliations

Soon will be listed here.

Abstract

The microbicidal activities of normal human pelvic macrophages against infection by the intracellular protozoa Toxoplasma gondii and Trypanosoma cruzi were examined. Macrophages allowed infection by T. gondii and yet possessed remarkable microbicidal activity against this organism. In contrast, human macrophages were not microbicidal against T. cruzi.

Citing Articles

Down-regulation of MHC class II molecules and inability to up-regulate class I molecules in murine macrophages after infection with Toxoplasma gondii.

Luder C, Lang T, Beuerle B, Gross U Clin Exp Immunol. 1998; 112(2):308-16.

PMID: 9649196 PMC: 1904980. DOI: 10.1046/j.1365-2249.1998.00594.x.

Infection of murine macrophages with Toxoplasma gondii is associated with release of transforming growth factor beta and downregulation of expression of tumor necrosis factor receptors.

Bermudez L, Covaro G, Remington J Infect Immun. 1993; 61(10):4126-30.

PMID: 8406801 PMC: 281134. DOI: 10.1128/iai.61.10.4126-4130.1993.

Remarkable in vitro and in vivo activities of the hydroxynaphthoquinone 566C80 against tachyzoites and tissue cysts of Toxoplasma gondii.

Araujo F, Huskinson J, Remington J Antimicrob Agents Chemother. 1991; 35(2):293-9.

PMID: 2024964 PMC: 244994. DOI: 10.1128/AAC.35.2.293.

References

Murray H, Gellene R, Libby D, Rothermel C, Rubin B . Activation of tissue macrophages from AIDS patients: in vitro response of AIDS alveolar macrophages to lymphokines and interferon-gamma. J Immunol. 1985; 135(4):2374-7. View

Anderson Jr S, Remington J . Effect of normal and activated human macrophages on Toxoplasma gondii. J Exp Med. 1974; 139(5):1154-74. PMC: 2139672. DOI: 10.1084/jem.139.5.1154. View

Catterall J, Black C, Leventhal J, Rizk N, Wachtel J, Remington J . Nonoxidative microbicidal activity in normal human alveolar and peritoneal macrophages. Infect Immun. 1987; 55(7):1635-40. PMC: 260570. DOI: 10.1128/iai.55.7.1635-1640.1987. View

TALIAFERRO W, PIZZI T . Connective tissue reactions in normal and immunized mice to a reticulotropic strain of Trypanosoma cruzi. J Infect Dis. 1955; 96(3):199-226. DOI: 10.1093/infdis/96.3.199. View

Wilson C, Tsai V, Remington J . Failure to trigger the oxidative metabolic burst by normal macrophages: possible mechanism for survival of intracellular pathogens. J Exp Med. 1980; 151(2):328-46. PMC: 2185778. DOI: 10.1084/jem.151.2.328. View