Acceleration of Autoimmunity in NZB/NZW F1 Mice by Graft-versus-host Disease

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1975 Feb 1

PMID 2403

Citations 1

Authors

R GOLDBLUM

R Pillarisetty

M J Dauphinee

N Talal

Affiliations

Soon will be listed here.

Abstract

Chronic graft-versus-host (GVH) disease was induced in NZB/NZW F1 (B/W) hybrid female mice by the weekly injection of parental NZB spleen cells. Control mice received injections of syngeneic spleen cells only. The mice were assayed for antibodies to [3H]DNA and [3H]polyadenylic-polyuridylic acid by a cellulose ester filter radioimmunoassay, and for antibody to thymocytes by a cytotoxicity method. GVH disease accelerated the development of all three antibodies in B/W mice. In addition, sucrose density gradient ultracentrifugation of pooled sera suggested that an accelerated switch from 19S to 7S anti-DNA production may be an early effect of GVH. The mechanism of acceleration is discussed in terms of immunological and viral factors generated by the GVH reaction.

Citing Articles

Increased survival times of New Zealand hybrid mice immunosuppressed by graft-versus-host reactions.

Lehman D, Wilson C, Dixon F Clin Exp Immunol. 1976; 25(2):297-302.

PMID: 8228 PMC: 1541357.

References

Talal N, Gallo R . Antibodies to a DNA:RNA hybrid in systemic lupus erythematosus measured by a cellulose ester filter radioimmunoassay. Nat New Biol. 1972; 240(103):240-2. DOI: 10.1038/newbio240240a0. View

Talal N, Steinberg A, Daley G . Inhibition of antigodies binding polyinosinic-polycytidylic acid in human and mouse lupus sera by viral and synthetic ribonucleic acids. J Clin Invest. 1971; 50(6):1248-52. PMC: 292054. DOI: 10.1172/JCI106602. View

Hirsch M, Black P, Tracy G, Leibowitz S, Schwartz R . Leukemia virus activation in chronic allogeneic disease. Proc Natl Acad Sci U S A. 1970; 67(4):1914-7. PMC: 283447. DOI: 10.1073/pnas.67.4.1914. View

Armstrong M, Black F, Richards F . Tumour induction by cell-free extracts derived from mice with graft versus host disease. Nat New Biol. 1972; 235(57):153-4. DOI: 10.1038/newbio235153a0. View

GERSHON R, Cohen P, Hencin R, Liebhaber S . Suppressor T cells. J Immunol. 1972; 108(3):586-90. View

Ordal J, Grumet F . Genetic control of the immune response. The effect of graft-versus-host reaction on the antibody response to poly-L(Tyr, Glu)-poly-D,L-Ala--poly-L-Lys in nonresponder mice. J Exp Med. 1972; 136(5):1195-206. PMC: 2139288. DOI: 10.1084/jem.136.5.1195. View

Shirai T, MELLORS R . Natural cytotoxic autoantibody against thymocytes in NZB mice. Clin Exp Immunol. 1972; 12(1):133-52. PMC: 1553652. View

Mitchell G, Grumet F, McDevitt H . Genetic control of the immune response. The effect of thymectomy on the primary and secondary antibody response of mice to poly-L(tyr, glu)-poly-D, L-ala--poly-L-lys. J Exp Med. 1972; 135(1):126-35. PMC: 2139121. DOI: 10.1084/jem.135.1.126. View

Greenspan J, Gutman G, Talal N, Weissman I, Sugai S . Thymus-antigen- and immunoglobulin- positive cells in lymph-nodes, thymus, and malignant lymphomas of NZB/NZW mice. Clin Immunol Immunopathol. 1974; 3(1):32-51. DOI: 10.1016/0090-1229(74)90021-x. View

10.

Attias M, Sylvester R, Talal N . Filter radioimmunoassay for antibodies to reovirus RNA in systemic lupus erythematosus. Arthritis Rheum. 1973; 16(6):719-25. DOI: 10.1002/art.1780160604. View

11.

MELLORS R . Autoimmune and immunoproliferative diseases of NZB/Bl mice and hybrids. Int Rev Exp Pathol. 1966; 5:217-52. View

12.

Lewis R, Armstrong M, Andre-Schwartz J, Muftuoglu A, BELDOTTI L, Schwartz R . Chronic allogeneic disease. I. Development of glomerulonephritis. J Exp Med. 1968; 128(4):653-79. PMC: 2138537. DOI: 10.1084/jem.128.4.653. View

13.

Droege W . Amplifying and suppressive effect of thymus cells. Nature. 1971; 234(5331):549-51. DOI: 10.1038/234549a0. View

14.

Shirai T, Yoshiki T, MELLORS R . Thymus dependence of cells in peripheral lymphoid tissues and in the circulation sensitive to natural thymocytotoxic autoantibody in NZB mice. J Immunol. 1972; 109(1):32-7. View

15.

Shirai T, MELLORS R . Natural thymocytotoxic autoantibody and reactive antigen in New Zealand black and other mice. Proc Natl Acad Sci U S A. 1971; 68(7):1412-5. PMC: 389206. DOI: 10.1073/pnas.68.7.1412. View

16.

Steinberg A, Pincus T, Talal N . DNA-binding assay for detection of anti-DNA antibodies in NZB-NZW F1 mice. J Immunol. 1969; 102(3):788-90. View

17.

Talal N . Immunologic and viral factors in the pathogenesis of systemic lupus erythematosus. Arthritis Rheum. 1970; 13(6):887-94. DOI: 10.1002/art.1780130620. View

18.

Armstrong M, Gleichmann E, Gleichmann H, BELDOTTI L, Andre-Schwartz J, Schwartz R . Chronic allogeneic disease. II. Development of lymphomas. J Exp Med. 1970; 132(3):417-39. PMC: 2138811. DOI: 10.1084/jem.132.3.417. View

19.

Schwartz R, BELDOTTI L . Malignant lymphomas following allogenic disease: transition from an immunological to a neoplastic disorder. Science. 1965; 149(3691):1511-4. DOI: 10.1126/science.149.3691.1511. View

20.

Claman H, Chaperon E, TRIPLETT R . Thymus-marrow cell combinations. Synergism in antibody production. Proc Soc Exp Biol Med. 1966; 122(4):1167-71. DOI: 10.3181/00379727-122-31353. View