Bridge Between Neuroimmunity and Traumatic Brain Injury

Overview

Journal Curr Pharm Des

Publisher Bentham Science Publishers

Date 2013 Sep 13

PMID 24025052

Citations 36

Authors

Matthew L Kelso

Howard E Gendelman

Affiliations

Soon will be listed here.

Abstract

The pathophysiology of degenerative, infectious, inflammatory and traumatic diseases of the central nervous system includes a significant immune component. As to the latter, damage to the cerebral vasculature and neural cell bodies, caused by traumatic brain injury (TBI) activates innate immunity with concomitant infiltration of immunocytes into the damaged nervous system. This leads to proinflammatory cytokine and prostaglandin production and lost synaptic integrity and more generalized neurotoxicity. Engagement of adaptive immune responses follows including the production of antibodies and lymphocyte proliferation. These affect the tempo of disease along with tissue repair and as such provide a number of potential targets for pharmacological treatments for TBI. However, despite a large body of research, no such treatment intervention is currently available. In this review we will discuss the immune response initiated following brain injuries, drawing on knowledge gained from a broad array of experimental and clinical studies. Our discussion seeks to address potential therapeutic targets and propose ways in which the immune system can be controlled to promote neuroprotection.

Citing Articles

The Emerging Role of Immunoglobulins and Complement in the Stimulation of Neuronal Activity and Repair: Not as Simple as We Thought.

Veremeyko T, Barteneva N, Vorobyev I, Ponomarev E Biomolecules. 2024; 14(10).

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Navigating the Complexities of Traumatic Encephalopathy Syndrome (TES): Current State and Future Challenges.

Fesharaki-Zadeh A Biomedicines. 2023; 11(12).

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Single Versus Repetitive Traumatic Brain Injury: Current Knowledge on the Chronic Outcomes, Neuropathology and the Role of TDP-43 Proteinopathy.

Jankovic T, Pilipovic K Exp Neurobiol. 2023; 32(4):195-215.

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AT 1 inhibition mediated neuroprotection after experimental traumatic brain injury is dependent on neutrophils in male mice.

Timaru-Kast R, Coronel-Castello S, Kramer T, Hugonnet A, Schafer M, Sebastiani A Sci Rep. 2023; 13(1):7413.

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Podoplanin: Its roles and functions in neurological diseases and brain cancers.

Wang Y, Peng D, Huang Y, Cao Y, Li H, Zhang X Front Pharmacol. 2022; 13:964973.

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