» Articles » PMID: 24024343

Pharmacological Effects of Astragaloside IV: a Literature Review

Overview
Date 2013 Sep 13
PMID 24024343
Citations 108
Authors
Affiliations
Soon will be listed here.
Abstract

Objective: To review the pharmacological effects and mechanisms of action of Astragaloside IV in Huangqi (Radix Astragali Mongolici).

Methods: Aticles focusing on Astragaloside IV in English and Chinese in databases were collected and reviewed in order to summarize the latest extraction separation, pharmacokinetics, and the pharmacological effects of astrageloside IV.

Results: Protective effects of Astrageloside IV on the cardiovascular system, immune, digestive, nervous system were identified, and the action mechanisms were associated with regulation of the calcium balance, anti-oxydant, antiapoptosis, antivirus, and so on.

Conclusion: Astrageloside IV has broad application prospects, especially in cardiovascular diseases, digestive diseases, cancer and other modern high incidence, high-risk diseases, and could be developed as a medicine.

Citing Articles

Efficacy and Safety of Herbal Medicine Bojungikki-Tang in Combination with Pembrolizumab versus Pembrolizumab Monotherapy for Stage IV Non-Small Cell Lung Cancer: Study Protocol for a Randomized, Open-Label, Double-Arm, Multicenter Trial.

Cho E, Yi J, Chun J, Jang H, Yoon S, Lee S Integr Cancer Ther. 2025; 24:15347354251319339.

PMID: 39985390 PMC: 11847320. DOI: 10.1177/15347354251319339.


Effects of Astragaloside IV and Formononetin on Oxidative Stress and Mitochondrial Biogenesis in Hepatocytes.

Tran Q, Tran G, Velic S, Xiong H, Kaur J, Moosavi Z Int J Mol Sci. 2025; 26(2).

PMID: 39859490 PMC: 11765978. DOI: 10.3390/ijms26020774.


Radix Astragali and Its Representative Extracts for Diabetic Nephropathy: Efficacy and Molecular Mechanism.

Xue H, Chen Y, Wang S, Yang Y, Cai L, Zhao J J Diabetes Res. 2024; 2024:5216113.

PMID: 39308629 PMC: 11416176. DOI: 10.1155/2024/5216113.


Research progress on the natural products in the intervention of myocardial infarction.

Guo Q, Wang J, Ni C, Pan J, Zou J, Shi Y Front Pharmacol. 2024; 15:1445349.

PMID: 39239656 PMC: 11374734. DOI: 10.3389/fphar.2024.1445349.


Development of semisynthetic saponin immunostimulants.

Bai D, Kim H, Wang P Med Chem Res. 2024; 33(8):1292-1306.

PMID: 39132259 PMC: 11315725. DOI: 10.1007/s00044-024-03227-x.