Lipofuscin: Formation, Effects and Role of Macroautophagy

Overview

Journal Redox Biol

Specialties Biology
Cell Biology
Endocrinology

Date 2013 Sep 12

PMID 24024146

Citations 122

Authors

Annika Hohn

Tilman Grune

Affiliations

Soon will be listed here.

Abstract

Oxidative stress plays a crucial role in the development of the aging process and age dependent diseases. Both are closely connected to disturbances of proteostasis by protein oxidation and an impairment of the proteasomal system. The final consequence is the accumulation of highly cross-linked undegradable aggregates such as lipofuscin. These aggregates of damaged proteins are detrimental to normal cell functions. Here we provide an overview about effect of these aggregates on the proteasomal system, followed by transcription factor activation and loss of cell viability. Furthermore, findings on the mechanism of radical genesis, proteasomal inhibition and the required components of lipofuscin formation were resumed.

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