Stability in Vitiligo: Is There a Perfect Way to Predict It?

Overview

Journal J Cutan Aesthet Surg

Date 2013 Sep 12

PMID 24023428

Citations 12

Authors

Kanika Sahni

Davinder Parsad

Affiliations

Soon will be listed here.

Abstract

Stability is a hard-to-define concept in the setting of vitiligo, but is nonetheless extremely crucial to the planning of treatment regimens and also in prognosticating for the patient. There are several ways to judge stability in vitiligo, which include clinical features and, recently, many biochemical, cytological and ultrastructural correlates of the same. These recent advances help in not only in prognosticating individual patients but also in elucidating some of the mechanisms for the pathogenesis of vitiligo, including melanocytorrhagy and oxidative damage to melanocytes.

Citing Articles

Ritlecitinib, a JAK3/TEC family kinase inhibitor, stabilizes active lesions and repigments stable lesions in vitiligo.

Yamaguchi Y, Peeva E, Del Duca E, Facheris P, Bar J, Shore R Arch Dermatol Res. 2024; 316(7):478.

PMID: 39023568 PMC: 11258076. DOI: 10.1007/s00403-024-03182-y.

Monitoring of Vitiligo Patches Over Six Months to Validate Dermoscopic Findings of Lesional Stability.

Kamath C, Dhurat R, Shah B, Sharma R, Kowe P, Chamle S Dermatol Pract Concept. 2023; 13(4).

PMID: 37992385 PMC: 10656188. DOI: 10.5826/dpc.1304a277.

Lesional CD8+ T-Cell Number Predicts Surgical Outcomes of Melanocyte-Keratinocyte Transplantation Surgery for Vitiligo.

Refat M, Strassner J, Frisoli M, Rashighi M, Richmond J, Nada E J Invest Dermatol. 2023; 143(11):2275-2282.e6.

PMID: 37478900 PMC: 11140410. DOI: 10.1016/j.jid.2023.03.1689.

Differential Expression and Functional Analysis of Plasma MicroRNAs in the Pathogenesis of Non-segmental Vitiligo.

Pektas S, Kara M, Dogan G, Pektas M, Baloglu M, Sadi G Indian J Dermatol. 2023; 67(6):705-714.

PMID: 36998849 PMC: 10043660. DOI: 10.4103/ijd.ijd_383_21.

Multimodal analyses of vitiligo skin identify tissue characteristics of stable disease.

Shiu J, Zhang L, Lentsch G, Flesher J, Jin S, Polleys C JCI Insight. 2022; 7(13).

PMID: 35653192 PMC: 9310536. DOI: 10.1172/jci.insight.154585.

References

Klarquist J, Denman C, Hernandez C, Wainwright D, Wainwright D, Strickland F . Reduced skin homing by functional Treg in vitiligo. Pigment Cell Melanoma Res. 2010; 23(2):276-86. PMC: 3778930. DOI: 10.1111/j.1755-148X.2010.00688.x. View

Gauthier Y, Andre M, Taieb A . A critical appraisal of vitiligo etiologic theories. Is melanocyte loss a melanocytorrhagy?. Pigment Cell Res. 2003; 16(4):322-32. DOI: 10.1034/j.1600-0749.2003.00070.x. View

Sharquie K, Mehenna S, Naji A, Al-Azzawi H . Inflammatory changes in vitiligo: stage I and II depigmentation. Am J Dermatopathol. 2004; 26(2):108-12. DOI: 10.1097/00000372-200404000-00004. View

Lahiri K, Malakar S, Banerjee U, Sarma N . Clinico-cellular stability of vitiligo in surgical repigmentation: an unexplored frontier. Dermatology. 2004; 209(2):170-1. DOI: 10.1159/000079612. View

Singh S, Singh U, Pandey S . Increased level of serum Homocysteine in vitiligo. J Clin Lab Anal. 2011; 25(2):110-2. PMC: 6647724. DOI: 10.1002/jcla.20442. View

al Badri A, Foulis A, Todd P, Gariouch J, Gudgeon J, Stewart D . Abnormal expression of MHC class II and ICAM-1 by melanocytes in vitiligo. J Pathol. 1993; 169(2):203-6. DOI: 10.1002/path.1711690205. View

Ardigo M, Malizewsky I, Dellanna M, Berardesca E, Picardo M . Preliminary evaluation of vitiligo using in vivo reflectance confocal microscopy. J Eur Acad Dermatol Venereol. 2007; 21(10):1344-50. DOI: 10.1111/j.1468-3083.2007.02275.x. View

Tu C, Zhao D, Lin X . Levels of neuropeptide-Y in the plasma and skin tissue fluids of patients with vitiligo. J Dermatol Sci. 2001; 27(3):178-82. DOI: 10.1016/s0923-1811(01)00134-7. View

Harning R, Cui J, Bystryn J . Relation between the incidence and level of pigment cell antibodies and disease activity in vitiligo. J Invest Dermatol. 1991; 97(6):1078-80. DOI: 10.1111/1523-1747.ep12492607. View

10.

Song Y, Connor E, Li Y, Zorovich B, Balducci P, Maclaren N . The role of tyrosinase in autoimmune vitiligo. Lancet. 1994; 344(8929):1049-52. DOI: 10.1016/s0140-6736(94)91709-4. View

11.

Mulekar S . Long-term follow-up study of segmental and focal vitiligo treated by autologous, noncultured melanocyte-keratinocyte cell transplantation. Arch Dermatol. 2004; 140(10):1211-5. DOI: 10.1001/archderm.140.10.1211. View

12.

Singh K, Bajaj A . Autologous miniature skin punch grafting in vitiligo. Indian J Dermatol Venereol Leprol. 2010; 61(2):77-80. View

13.

Ahn S, Choi E, Lee S, Won J, Hann S, Park Y . Immunohistochemical studies from vitiligo--comparison between active and inactive lesions. Yonsei Med J. 1994; 35(4):404-10. DOI: 10.3349/ymj.1994.35.4.404. View

14.

Benzekri L, Gauthier Y, Hamada S, Hassam B . Clinical features and histological findings are potential indicators of activity in lesions of common vitiligo. Br J Dermatol. 2012; 168(2):265-71. DOI: 10.1111/bjd.12034. View

15.

Cui J, Harning R, Henn M, Bystryn J . Identification of pigment cell antigens defined by vitiligo antibodies. J Invest Dermatol. 1992; 98(2):162-5. DOI: 10.1111/1523-1747.ep12555773. View

16.

Ines D, Sonia B, Riadh B, Amel E, Slaheddine M, Hamida T . A comparative study of oxidant-antioxidant status in stable and active vitiligo patients. Arch Dermatol Res. 2006; 298(4):147-52. DOI: 10.1007/s00403-006-0680-2. View

17.

Cui J, Arita Y, Bystryn J . Cytolytic antibodies to melanocytes in vitiligo. J Invest Dermatol. 1993; 100(6):812-5. DOI: 10.1111/1523-1747.ep12476636. View

18.

Okamoto T, Irie R, Fujii S, Huang S, Nizze A, Morton D . Anti-tyrosinase-related protein-2 immune response in vitiligo patients and melanoma patients receiving active-specific immunotherapy. J Invest Dermatol. 1998; 111(6):1034-9. DOI: 10.1046/j.1523-1747.1998.00411.x. View

19.

Malakar S, Lahiri K, Malakar R . How unstable is the concept of stability in surgical repigmentation of vitiligo?. Dermatology. 2000; 201(2):182-3. DOI: 10.1159/000018449. View

20.

Kumar R, Parsad D, Kanwar A . Role of apoptosis and melanocytorrhagy: a comparative study of melanocyte adhesion in stable and unstable vitiligo. Br J Dermatol. 2010; 164(1):187-91. DOI: 10.1111/j.1365-2133.2010.10039.x. View