Cu(2+)-responsive Bimodal (optical/MRI) Contrast Agent for Cellular Imaging

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2013 Sep 11

PMID 24015763

Citations 11

Authors

Joo Hee Jang

Sankarprasad Bhuniya

Jongeun Kang

Areum Yeom

Kwan Soo Hong

Jong Seung Kim

Affiliations

Soon will be listed here.

Abstract

A water-soluble T1 magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu(2+) ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.

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