Endothelial Dysfunction over the Course of Coronary Artery Disease

Overview

Journal Eur Heart J

Publisher Oxford University Press

Specialty Cardiology & Vascular Diseases

Date 2013 Sep 10

PMID 24014385

Citations 140

Authors

Enrique Gutierrez

Andreas J Flammer

Lilach O Lerman

Jaime Elizaga

Amir Lerman

Francisco Fernandez-Aviles

Affiliations

Soon will be listed here.

Abstract

The vascular endothelium regulates blood flow in response to physiological needs. Endothelial dysfunction is closely related to atherosclerosis and its risk factors, and it constitutes an intermediate step on the progression to adverse events throughout the natural history of coronary artery disease (CAD), often affecting clinical outcomes. Understanding the relation of endothelial function with CAD provides an important pathophysiological insight, which can be useful both in clinical and research management. In this review, we summarize the current knowledge on endothelial dysfunction and its prognostic influence throughout the natural history of CAD, from early atherosclerosis to post-transplant management.

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