The Value of Serum Albumin As a Novel Independent Marker for Prognosis in Patients with Endometrial Cancer

Overview

Journal Eur J Obstet Gynecol Reprod Biol

Specialties Gynecology & Obstetrics
Reproductive Medicine

Date 2013 Sep 10

PMID 24011381

Citations 28

Authors

Veronika Seebacher

Christoph Grimm

Alexander Reinthaller

Georg Heinze

Clemens Tempfer

Lukas Hefler

Stephan Polterauer

Affiliations

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Abstract

Objective: Hypoalbuminemia, a known marker for malnutrition and increased morbidity and mortality, has been associated with impaired prognosis in different cancer entities. The present study investigates the prognostic value of pre-treatment serum albumin levels for survival in patients with endometrial cancer.

Study Design: Within the present cohort study, we evaluated 337 consecutive patients with endometrial cancer and investigated the association of pre-treatment serum albumin levels and clinical-pathological parameters. We performed univariate log-rank tests and multivariable Cox regression models to assess the association between pre-treatment serum albumin levels and survival.

Results: Pre-treatment serum albumin levels were inversely proportionally associated with FIGO tumor stage, histological grade, and patients' age. In a multivariable analysis pre-treatment serum albumin levels (p = 0.02 and p = 0.001), FIGO tumor stage (p < 0.001 and p < 0.001), and histological grade (p = 0.002 and p < 0.001) were independently associated with disease-free and progression-free survival, respectively.

Conclusion: Pre-treatment serum albumin is a novel and independent prognostic parameter for disease-free and progression-free survival in patients with endometrial cancer.

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