Human Cardiac 31P Magnetic Resonance Spectroscopy at 7 Tesla

Overview

Journal Magn Reson Med

Publisher Wiley

Specialty Radiology

Date 2013 Sep 6

PMID 24006267

Citations 56

Authors

Christopher T Rodgers

William T Clarke

Carl Snyder

J Thomas Vaughan

Stefan Neubauer

Matthew D Robson

Affiliations

Soon will be listed here.

Abstract

Purpose: Phosphorus magnetic resonance spectroscopy ((31)P-MRS) affords unique insight into cardiac energetics but has a low intrinsic signal-to-noise ratio (SNR) in humans. Theory predicts an increased (31)P-MRS SNR at 7T, offering exciting possibilities to better investigate cardiac metabolism. We therefore compare the performance of human cardiac (31)P-MRS at 7T to 3T, and measure T1s for (31)P metabolites at 7T.

Methods: Matched (31)P-MRS data were acquired at 3T and 7T, on nine normal volunteers. A novel Look-Locker CSI acquisition and fitting approach was used to measure T1s on six normal volunteers.

Results: T1s in the heart at 7T were: phosphocreatine (PCr) 3.05 ± 0.41s, γ-ATP 1.82 ± 0.09s, α-ATP 1.39 ± 0.09s, β-ATP 1.02 ± 0.17s and 2,3-DPG (2,3-diphosphoglycerate) 3.05 ± 0.41s (N = 6). In the field comparison (N = 9), PCr SNR increased 2.8× at 7T relative to 3T, the Cramer-Ráo uncertainty (CRLB) in PCr concentration decreased 2.4×, the mean CRLB in PCr/ATP decreased 2.7× and the PCr/ATP SD decreased 2×.

Conclusion: Cardiac (31)P-MRS at 7T has higher SNR and the spectra can be quantified more precisely than at 3T. Cardiac (31)P T1s are shorter at 7T than at 3T. We predict that 7T will become the field strength of choice for cardiac (31)P-MRS.

Citing Articles

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Bozymski B, Shen X, Ozen A, Chiew M, Thomas M, Clarke W Sci Rep. 2025; 15(1):6465.

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Mapping intracellular NAD content in entire human brain using phosphorus-31 MR spectroscopic imaging at 7 Tesla.

Guo R, Yang S, Wiesner H, Li Y, Zhao Y, Liang Z Front Neurosci. 2024; 18:1389111.

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3D ultra-short echo time P-MRSI with rosette k-space pattern: Feasibility and comparison with conventional weighted CSI.

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Compartment-based reconstruction of acquisition-weighted P cardiac MRSI reduces sensitivity to cardiac motion and scan planning.

Tyler A, Hundertmark M, Miller J, Rider O, Tyler D, Valkovic L Front Physiol. 2024; 14:1325458.

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Ultra-high field cardiac MRI in large animals and humans for translational cardiovascular research.

Schreiber L, Lohr D, Baltes S, Vogel U, Elabyad I, Bille M Front Cardiovasc Med. 2023; 10:1068390.

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References

Friedrich J, Nascimben L, Liao R, Ingwall J . Phosphocreatine T1 measurements with and without exchange in the heart. Magn Reson Med. 1993; 30(1):45-50. DOI: 10.1002/mrm.1910300108. View

Hudsmith L, Neubauer S . Detection of myocardial disorders by magnetic resonance spectroscopy. Nat Clin Pract Cardiovasc Med. 2008; 5 Suppl 2:S49-56. DOI: 10.1038/ncpcardio1158. View

Moser E . Ultra-high-field magnetic resonance: Why and when?. World J Radiol. 2010; 2(1):37-40. PMC: 2999312. DOI: 10.4329/wjr.v2.i1.37. View

El-Sharkawy A, Schar M, Ouwerkerk R, Weiss R, Bottomley P . Quantitative cardiac 31P spectroscopy at 3 Tesla using adiabatic pulses. Magn Reson Med. 2009; 61(4):785-95. PMC: 3084604. DOI: 10.1002/mrm.21867. View

Yabe T, Mitsunami K, Inubushi T, Kinoshita M . Quantitative measurements of cardiac phosphorus metabolites in coronary artery disease by 31P magnetic resonance spectroscopy. Circulation. 1995; 92(1):15-23. DOI: 10.1161/01.cir.92.1.15. View

Rider O, Francis J, Ali M, Holloway C, Pegg T, Robson M . Effects of catecholamine stress on diastolic function and myocardial energetics in obesity. Circulation. 2012; 125(12):1511-9. DOI: 10.1161/CIRCULATIONAHA.111.069518. View

Schar M, El-Sharkawy A, Weiss R, Bottomley P . Triple repetition time saturation transfer (TRiST) 31P spectroscopy for measuring human creatine kinase reaction kinetics. Magn Reson Med. 2010; 63(6):1493-501. PMC: 2926802. DOI: 10.1002/mrm.22347. View

Holloway C, Suttie J, Dass S, Neubauer S . Clinical cardiac magnetic resonance spectroscopy. Prog Cardiovasc Dis. 2011; 54(3):320-7. DOI: 10.1016/j.pcad.2011.08.002. View

Moser E, Stahlberg F, Ladd M, Trattnig S . 7-T MR--from research to clinical applications?. NMR Biomed. 2011; 25(5):695-716. DOI: 10.1002/nbm.1794. View

10.

Redpath T . Signal-to-noise ratio in MRI. Br J Radiol. 1998; 71(847):704-7. DOI: 10.1259/bjr.71.847.9771379. View

11.

Bottomley P, Ouwerkerk R, Lee R, Weiss R . Four-angle saturation transfer (FAST) method for measuring creatine kinase reaction rates in vivo. Magn Reson Med. 2002; 47(5):850-63. PMC: 1995126. DOI: 10.1002/mrm.10130. View

12.

Rodgers C, Piechnik S, Delabarre L, Van de Moortele P, Snyder C, Neubauer S . Inversion recovery at 7 T in the human myocardium: measurement of T(1), inversion efficiency and B(1) (+). Magn Reson Med. 2012; 70(4):1038-46. PMC: 4134266. DOI: 10.1002/mrm.24548. View

13.

Robson M, Tyler D, Neubauer S . Ultrashort TE chemical shift imaging (UTE-CSI). Magn Reson Med. 2005; 53(2):267-74. DOI: 10.1002/mrm.20344. View

14.

Bottomley P, Ouwerkerk R . Optimum flip-angles for exciting NMR with uncertain T1 values. Magn Reson Med. 1994; 32(1):137-41. DOI: 10.1002/mrm.1910320120. View

15.

Tyler D, Emmanuel Y, Cochlin L, Hudsmith L, Holloway C, Neubauer S . Reproducibility of 31P cardiac magnetic resonance spectroscopy at 3 T. NMR Biomed. 2008; 22(4):405-13. DOI: 10.1002/nbm.1350. View

16.

Neubauer S . The failing heart--an engine out of fuel. N Engl J Med. 2007; 356(11):1140-51. DOI: 10.1056/NEJMra063052. View

17.

Tyler D, Hudsmith L, Clarke K, Neubauer S, Robson M . A comparison of cardiac (31)P MRS at 1.5 and 3 T. NMR Biomed. 2008; 21(8):793-8. DOI: 10.1002/nbm.1255. View

18.

Bogner W, Chmelik M, Schmid A, Moser E, Trattnig S, Gruber S . Assessment of (31)P relaxation times in the human calf muscle: a comparison between 3 T and 7 T in vivo. Magn Reson Med. 2009; 62(3):574-82. DOI: 10.1002/mrm.22057. View

19.

Luo Y, de Graaf R, Delabarre L, Tannus A, Garwood M . BISTRO: an outer-volume suppression method that tolerates RF field inhomogeneity. Magn Reson Med. 2001; 45(6):1095-102. DOI: 10.1002/mrm.1144. View

20.

Hetherington H, Luney D, Vaughan J, Pan J, Ponder S, Tschendel O . 3D 31P spectroscopic imaging of the human heart at 4.1 T. Magn Reson Med. 1995; 33(3):427-31. DOI: 10.1002/mrm.1910330318. View