Global Differences in Specific Histone H3 Methylation Are Associated with Overweight and Type 2 Diabetes

Overview

Journal Clin Epigenetics

Publisher Biomed Central

Specialty Genetics

Date 2013 Sep 6

PMID 24004477

Citations 17

Authors

Asa Jufvas

Simon Sjodin

Kim Lundqvist

Risul Amin

Alexander V Vener

Peter Stralfors

Affiliations

Soon will be listed here.

Abstract

Background: Epidemiological evidence indicates yet unknown epigenetic mechanisms underlying a propensity for overweight and type 2 diabetes. We analyzed the extent of methylation at lysine 4 and lysine 9 of histone H3 in primary human adipocytes from 43 subjects using modification-specific antibodies.

Results: The level of lysine 9 dimethylation was stable, while adipocytes from type 2 diabetic and non-diabetic overweight subjects exhibited about 40% lower levels of lysine 4 dimethylation compared with cells from normal-weight subjects. In contrast, trimethylation at lysine 4 was 40% higher in adipocytes from overweight diabetic subjects compared with normal-weight and overweight non-diabetic subjects. There was no association between level of modification and age of subjects.

Conclusions: The findings define genome-wide molecular modifications of histones in adipocytes that are directly associated with overweight and diabetes, and thus suggest a molecular basis for existing epidemiological evidence of epigenetic inheritance.

Citing Articles

Epigenetics and Beyond: Targeting Histone Methylation to Treat Type 2 Diabetes Mellitus.

Yang Y, Luan Y, Feng Q, Chen X, Qin B, Ren K Front Pharmacol. 2022; 12:807413.

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H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity.

Liu M, Espinosa-Diez C, Mahan S, Du M, Nguyen A, Hahn S Dev Cell. 2021; 56(19):2765-2782.e10.

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Adipose Tissue Epigenetic Profile in Obesity-Related Dysglycemia - A Systematic Review.

Andrade S, Morais T, Sandovici I, Seabra A, Constancia M, Monteiro M Front Endocrinol (Lausanne). 2021; 12:681649.

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Epigenetic Regulation of Adipogenesis in Development of Metabolic Syndrome.

Pant R, Firmal P, Shah V, Alam A, Chattopadhyay S Front Cell Dev Biol. 2021; 8:619888.

PMID: 33511131 PMC: 7835429. DOI: 10.3389/fcell.2020.619888.

Obesity-induced nucleosome release predicts poor cardio-metabolic health.

Lo Re O, Maugeri A, Hruskova J, Jakubik J, Kucera J, Bienertova-Vasku J Clin Epigenetics. 2020; 12(1):2.

PMID: 31892362 PMC: 6938639. DOI: 10.1186/s13148-019-0797-8.

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