Electrical Stimulation of the Motor Cortex Enhances Progenitor Cell Migration in the Adult Rat Brain

Overview

Journal Exp Brain Res

Specialty Neurology

Date 2013 Sep 5

PMID 24002672

Citations 14

Authors

Ali Jahanshahi

Lisa Schonfeld

Marcus L F Janssen

Sarah Hescham

Ersoy Kocabicak

Harry W M Steinbusch

Jacobus J Van Overbeeke

Yasin Temel

Affiliations

Soon will be listed here.

Abstract

Clinical and preclinical investigations suggest that epidural stimulation of the motor cortex (MC) can improve stroke-induced neurological deficits. The mechanisms involved in stimulation-induced recovery are not well understood and might involve neurogenesis-related processes. Here, we addressed the question whether MC stimulation influences processes of migration and differentiation of neuronal progenitor cells in vivo. Epidural stimulation electrodes were implanted at the level of the MC in rats, and electrical current was applied for a period of 1 month. Increased cell proliferation was observed in the subventricular zone (SVZ). We also found evidences for enhanced cell migration toward the source of current, a process known as electrotaxis. Some of these cells expressed the neuronal marker, NeuN. In addition, our results indicate that MC stimulation enhances neuronal activity of the dorsal raphe nucleus, leading to an increase in the expression of 5-hydroxytryptamine in the SVZ. It is known that such an increase can promote formation of new cells in the SVZ. Our findings suggest that epidural MC stimulation influences neurogenesis-related processes in animal models.

Citing Articles

Electrical stimulation affects the differentiation of transplanted regionally specific human spinal neural progenitor cells (sNPCs) after chronic spinal cord injury.

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Diversified Treatment Options of Adult Stem Cells for Optic Neuropathies.

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Short-Term Cortical Electrical Stimulation during the Acute Stage of Traumatic Brain Injury Improves Functional Recovery.

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The Effect of Noise Trauma and Deep Brain Stimulation of the Medial Geniculate Body on Tissue Activity in the Auditory Pathway.

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How Do Electric Fields Coordinate Neuronal Migration and Maturation in the Developing Cortex?.

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