A Novel Partner of Scalloped Regulates Hippo Signaling Via Antagonizing Scalloped-Yorkie Activity

Overview

Journal Cell Res

Specialty Cell Biology

Date 2013 Sep 4

PMID 23999857

Citations 54

Authors

Tong Guo

Yi Lu

Peixue Li

Meng-Xin Yin

Dekang Lv

Wenjing Zhang

Huizhen Wang

Zhaocai Zhou

Hongbin Ji

Yun Zhao

Lei Zhang

Affiliations

Soon will be listed here.

Abstract

The Hippo (Hpo) pathway controls tissue growth and organ size by regulating the activity of transcriptional co-activator Yorkie (Yki), which associates with transcription factor Scalloped (Sd) in the nucleus to promote downstream target gene expression. Here we identify a novel protein Sd-Binding-Protein (SdBP)/Tgi, which directly competes with Yki for binding to Sd through its TDU domains and inhibits the Sd-Yki transcriptional activity. We also find that SdBP retains Yki in the nucleus through the association with Yki WW domains via its PPXY motifs. Collectively, we identify SdBP as a novel component of the Hpo pathway, negatively regulating the transcriptional activity of Sd-Yki to restrict tissue growth.

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