Preeclampsia and Sleep-Disordered Breathing: A Case-Control Study

Overview

Journal Pregnancy Hypertens

Publisher Elsevier

Date 2013 Sep 3

PMID 23997999

Citations 11

Authors

Francesca L Facco

Justin Lappen

Courtney Lim

Phyllis C Zee

William A Grobman

Affiliations

Soon will be listed here.

Abstract

Objective: To determine whether sleep-disordered breathing (SDB) is more prevalent among women with preeclampsia than among normotensive controls.

Study Design: Preeclamptic patients admitted to the hospital for observation and normotensive, gestational age matched controls hospitalized for obstetrical indications other than preeclampsia were recruited for an overnight sleep evaluation. Watch-PAT100, a validated wrist-mounted, ambulatory device designed to diagnose SDB, was used to complete all sleep studies.

Results: Twenty preeclamptic patients and 20 controls were recruited. Preeclamptic subjects had a higher mean BMI (32.6± 9.5 vs. 24.5 ± 3.5, P=0.001). Preeclamptic subjects had higher mean respiratory disturbance (RDI, mean difference 4.9 events/hour of sleep), apnea hypopnea (AHI, mean difference 5.7 events/hour of sleep) and oxygen desaturation (ODI, mean difference 4.5 events/hour of sleep) indices, however these differences did not reach statistical significance. Preeclamptic subjects were more likely to have more severe forms of SDB compared to controls (ODI ≥ 5, 20% vs. 0%, p=.047).

Conclusion: Compared to normotensive controls, preeclamptic subjects experience more SDB events and a greater degree of nocturnal hypoxemia. Further research is needed to determine if SBD, independent of BMI, is a significant contributing factor to the risk of developing preeclampsia.

Citing Articles

A comprehensive and bias-free machine learning approach for risk prediction of preeclampsia with severe features in a nulliparous study cohort.

Lin Y, Mallia D, Clark-Sevilla A, Catto A, Leshchenko A, Yan Q BMC Pregnancy Childbirth. 2024; 24(1):853.

PMID: 39716098 PMC: 11667971. DOI: 10.1186/s12884-024-06988-w.

Sleep Quality in Individuals with and without Persistent Postpartum Hypertension.

Wang T, Bryan S, Jeyabalan A, Facco F, Gandley R, Hubel C Am J Perinatol. 2024; 41(9):1113-1119.

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The effect of a neonatal sleep intervention on maternal postpartum hypertension: a randomized trial.

Wang T, Quinn B, Hart R, Wiener A, Facco F, Simhan H Am J Obstet Gynecol MFM. 2023; 6(2):101239.

PMID: 38072236 PMC: 10922913. DOI: 10.1016/j.ajogmf.2023.101239.

Sleep-Disordered Breathing in Pregnancy.

Konstanty-Kurkiewicz V, Dzieciolowska-Baran E, Szczurowski J, Gawlikowska-Sroka A Adv Exp Med Biol. 2021; 1375:101-109.

PMID: 34970727 DOI: 10.1007/5584_2021_691.

Mild maternal sleep-disordered breathing during pregnancy and offspring growth and adiposity in the first 3 years of life.

Brener A, Lebenthal Y, Levy S, Dunietz G, Sever O, Tauman R Sci Rep. 2020; 10(1):13979.

PMID: 32814798 PMC: 7438510. DOI: 10.1038/s41598-020-70911-4.

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