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[How and when to Evaluate Hypospadias?]

Overview
Journal Arch Pediatr
Publisher Elsevier
Specialty Pediatrics
Date 2013 Sep 3
PMID 23992834
Citations 4
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Abstract

Hypospadias is a frequent congenital malformation, which severity is connected to the spongiosum divergence. Biological and anatomical explorations are necessary, before the recourse to the surgeon, in posterior hypospadias, familial hypospadias, but also in any type of hypospadias associated with cryptorchidism, bifid scrotum, micropenis less than 20mm (full-term newborn), or any other anomaly (skeletal, renal, cardiac…). The "mini-puberty", occurring in the first 4-6 months of life, is a period of intense gonadotropic activity in male newborns. It allows an easy investigation of the testicular function in boys with hypospadias. Hormonal evaluation (testosterone, AMH) should be done the first day of life. Let us remind that a newborn with "hypospadias" and bilateral cryptorchidism must be considered, until proved otherwise, as a girl with congenital adrenal hyperplasia.

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Interaction between CYP1A1/CYP17A1 polymorphisms and parental risk factors in the risk of hypospadias in a Chinese population.

Mao Y, Zhang K, Ma L, Yun X, Ou F, Liu G Sci Rep. 2019; 9(1):4123.

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Maternal Exposure to Domestic Hair Cosmetics and Occupational Endocrine Disruptors Is Associated with a Higher Risk of Hypospadias in the Offspring.

Haraux E, Braun K, Buisson P, Stephan-Blanchard E, Devauchelle C, Ricard J Int J Environ Res Public Health. 2016; 14(1).

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Risk factors for hypospadias in China.

Xu L, Liang C, Lipianskaya J, Chen X, Fan S, Zhang L Asian J Androl. 2014; 16(5):778-81.

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