Association of Estrogen Receptor α Genes PvuII and XbaI Polymorphisms with Type 2 Diabetes Mellitus in the Inpatient Population of a Hospital in Southern Iran

Overview

Journal Diabetes Metab J

Specialty Endocrinology

Date 2013 Aug 31

PMID 23991405

Citations 5

Authors

Farzaneh Mohammadi

Mohammad Pourahmadi

Mohadeseh Mosalanejad

Houshang Jamali

Mohamed Amin Ghobadifar

Saeideh Erfanian

Affiliations

Soon will be listed here.

Abstract

Background: Estrogen plays a fundamental role in the pathogenesis of type 2 diabetes mellitus (T2DM). Very few studies have shown the association between estrogen receptor α (ERα), PvuII and XbaI gene polymorphisms with T2DM in both men and women. We evaluated the hypothesis that PvuII and XbaI polymorphisms of ERα gene may be associated with T2DM in adult.

Methods: From spring of 2010 to the fall of 2011, a case-control study was performed at clinical centers of Jahrom University of Medical Sciences. We included 174 patients with T2DM including men and women and 174 age, sex, and body mass index frequency-matched health controls. We analyzed the PvuII and XbaI polymorphisms of ERα by using the polymerase chain reaction-based restriction fragment length polymorphism method.

Results: No significant differences between demographic characteristics of control and patients groups were observed. Allele frequencies of both PvuII and XbaI polymorphisms were significantly different between patients and control subjects (P=0.014 vs. P=0.002, respectively). When the group was separated into women and men, logistic regression analysis of genotype distribution of PvuII (pp vs. Pp+PP) in both sexes revealed that there was no significant association of PvuII genotype with men (odds ratio [OR], 1.67; confidence interval [CI], 0.86 to 3.28; P=0.89) and women (OR, 0.96; CI, 0.53 to 1.74; P=0.12).

Conclusion: PvuII and XbaI polymorphisms in ERα are related with T2DM in the inpatient population.

Citing Articles

Analysis of Single Nucleotide Polymorphisms (SNPs) rs2234693 and rs9340799 of the Gene and the Risk of Breast Cancer.

Smolarz B, Nowak A, Brys M, Forma E, Lukasiewicz H, Samulak D In Vivo. 2024; 38(5):2134-2143.

PMID: 39187368 PMC: 11363788. DOI: 10.21873/invivo.13676.

Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population.

Akhlaghipour I, Bina A, Mogharrabi M, Fanoodi A, Ebrahimian A, Khojasteh Kaffash S Hum Genomics. 2022; 16(1):11.

PMID: 35366956 PMC: 8976361. DOI: 10.1186/s40246-022-00383-2.

Estrogen receptor 1 gene polymorphisms (PvuII and XbaI) are associated with type 2 diabetes in Palestinian women.

Ereqat S, Cauchi S, Eweidat K, Elqadi M, Nasereddin A PeerJ. 2019; 7:e7164.

PMID: 31293826 PMC: 6601601. DOI: 10.7717/peerj.7164.

Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies.

Khodaeian M, Enayati S, Tabatabaei-Malazy O, Amoli M J Diabetes Res. 2015; 2015:585917.

PMID: 26587547 PMC: 4637497. DOI: 10.1155/2015/585917.

Genetic polymorphism of estrogen receptor alpha gene in Egyptian women with type II diabetes mellitus.

Motawi T, El-Rehany M, Rizk S, Ramzy M, El-Roby D Meta Gene. 2015; 6:36-41.

PMID: 26401488 PMC: 4561236. DOI: 10.1016/j.mgene.2015.08.001.

References

Tanaka Y, Sasaki M, Kaneuchi M, Shiina H, Igawa M, Dahiya R . Polymorphisms of estrogen receptor alpha in prostate cancer. Mol Carcinog. 2003; 37(4):202-8. DOI: 10.1002/mc.10138. View

Newton K, LaCroix A, Heckbert S, Abraham L, McCulloch D, Barlow W . Estrogen therapy and risk of cardiovascular events among women with type 2 diabetes. Diabetes Care. 2003; 26(10):2810-6. DOI: 10.2337/diacare.26.10.2810. View

Daga A, Fabbi M, Mattioni T, Bertolini S, Corte G . Pvu II polymorphism of low density lipoprotein receptor gene and familial hypercholesterolemia. Study of Italians. Arteriosclerosis. 1988; 8(6):845-50. DOI: 10.1161/01.atv.8.6.845. View

Morita T, Tabata S, Mineshita M, Mizoue T, Moore M, Kono S . The metabolic syndrome is associated with increased risk of colorectal adenoma development: the Self-Defense Forces health study. Asian Pac J Cancer Prev. 2006; 6(4):485-9. View

Brandi M, Becherini L, Gennari L, Racchi M, Bianchetti A, Nacmias B . Association of the estrogen receptor alpha gene polymorphisms with sporadic Alzheimer's disease. Biochem Biophys Res Commun. 1999; 265(2):335-8. DOI: 10.1006/bbrc.1999.1665. View

Pollare T, Lithell H, Berne C . Insulin resistance is a characteristic feature of primary hypertension independent of obesity. Metabolism. 1990; 39(2):167-74. DOI: 10.1016/0026-0495(90)90071-j. View

Speer G, Cseh K, Winkler G, Vargha P, Braun E, Takacs I . Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity. Eur J Endocrinol. 2001; 144(4):385-9. DOI: 10.1530/eje.0.1440385. View

Dunning A, Healey C, Pharoah P, Teare M, Ponder B, Easton D . A systematic review of genetic polymorphisms and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 1999; 8(10):843-54. View

Kikuchi T, Hashimoto N, Kawasaki T, Uchiyama M . Association of serum low-density lipoprotein metabolism with oestrogen receptor gene polymorphisms in healthy children. Acta Paediatr. 2000; 89(1):42-5. DOI: 10.1080/080352500750029040. View

10.

Dahlman I, Vaxillaire M, Nilsson M, Lecoeur C, Gu H, Cavalcanti-Proenca C . Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose. Pharmacogenet Genomics. 2008; 18(11):967-75. DOI: 10.1097/FPC.0b013e32831101ef. View

11.

Zhang Y, Howard B, Cowan L, Yeh J, Schaefer C, Wild R . The effect of estrogen use on levels of glucose and insulin and the risk of type 2 diabetes in american Indian postmenopausal women : the strong heart study. Diabetes Care. 2002; 25(3):500-4. DOI: 10.2337/diacare.25.3.500. View

12.

Zarei S, Bigizadeh S, Pourahmadi M, Ghobadifar M . Chronic Pain and Its Determinants: A Population-based Study in Southern Iran. Korean J Pain. 2012; 25(4):245-53. PMC: 3468801. DOI: 10.3344/kjp.2012.25.4.245. View

13.

ALBRINK M, MEIGS J . The relationship between serum triglycerides and skinfold thickness in obese subjects. Ann N Y Acad Sci. 1965; 131(1):673-83. DOI: 10.1111/j.1749-6632.1965.tb34830.x. View

14.

Xiang K, Wang Y, Zheng T, Jia W, Li J, Chen L . Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese: significant linkage to chromosome 6q21-q23 and chromosome 1q21-q24. Diabetes. 2003; 53(1):228-34. DOI: 10.2337/diabetes.53.1.228. View

15.

Sand P, Luckhaus C, Schlurmann K, Gotz M, Deckert J . Untangling the human estrogen receptor gene structure. J Neural Transm (Vienna). 2002; 109(5-6):567-83. DOI: 10.1007/s007020200047. View

16.

Matsushita H, Kurabayashi T, Tomita M, Tanaka K . Effects of vitamin D and estrogen receptor gene polymorphisms on the changes in lumbar bone mineral density with multiple pregnancies in Japanese women. Hum Reprod. 2003; 19(1):59-64. DOI: 10.1093/humrep/deh009. View

17.

Shearman A, Cooper J, Kotwinski P, Miller G, Humphries S, Ardlie K . Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts. Circ Res. 2006; 98(5):590-2. DOI: 10.1161/01.RES.0000210578.62102.a6. View

18.

Ganasyam S, Bhaskar Rao T, Murthy Y, Jyothy A, Sujatha M . Association of Estrogen Receptor-α Gene & Metallothionein-1 Gene Polymorphisms in Type 2 Diabetic Women of Andhra Pradesh. Indian J Clin Biochem. 2013; 27(1):69-73. PMC: 3286578. DOI: 10.1007/s12291-011-0179-2. View

19.

Deng H, Li J, Li J, Johnson M, Gong G, Recker R . Association of VDR and estrogen receptor genotypes with bone mass in postmenopausal Caucasian women: different conclusions with different analyses and the implications. Osteoporos Int. 2000; 9(6):499-507. DOI: 10.1007/s001980050177. View

20.

JENG M, Shupnik M, Bender T, Westin E, Bandyopadhyay D, Kumar R . Estrogen receptor expression and function in long-term estrogen-deprived human breast cancer cells. Endocrinology. 1998; 139(10):4164-74. DOI: 10.1210/endo.139.10.6229. View