Ultrasound Biomicroscopic Evaluation of Anterior Segment Cysts As a Risk Factor for Ocular Hypertension and Closure Angle Glaucoma

Overview

Journal Int J Ophthalmol

Specialty Ophthalmology

Date 2013 Aug 31

PMID 23991389

Citations 2

Authors

Abdurrahim Dusak

Mehmet Baykara

Guven Ozkaya

Cuneyt Erdogan

Hikmet Ozcetin

Ercan Tuncel

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate the relationship between the ultrasound biomicroscopic (UBM) features of anterior-segment cysts (ASCs) and increased intraocular pressure (IOP) as a risk factor for closed-angle glaucoma (CAG).

Methods: Totally 24 eyes with recently diagnosed ASCs were divided into two groups. First group with ASC and ocular normotension (n=13), second group with ASC and ocular hypertension (n=11). An ophthalmologic examination, including tonometry, slit-lamp biomicroscopy (SLBM), gonioscopy, fundoscopy, pentacam, and UBM, was performed. The features of the ASCs were compared with the IOP.

Results: ASCs were accurately diagnosed and delineated in 24 eyes using UBM. IOP was elevated in those ASCs with a secondary aetiology (P=0.027), iridociliary location (P=0.006), deformed shape (P=0.013), increased size (P=0.001) and elongated pupillary aperture (P=0.009). However, the count (P=0.343) of ASCs, anterior chamber depth (ACD; P=0.22) and axial lenght (AL; P=0.31) were not associated with ocular hypertension. Correlations were found between the IOP and ASC size (r=-0.712; P=0.003), anterior chamber angle (ACA; r=-0.985; P<0.001), angle opening area (AOA; r=0.885; P<0.001), angulation of iris (r=-0.776, P<0.001), and affected iris quadrant (r =-0.655, P=0.002).

Conclusion: Ocular hypertension in some eyes with ASC might be associated with various mechanisms, including secondary aetiology, iridociliary location, deformed shape, increased size and elongated pupill, which can be determined by UBM.

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References

Chan R, Pong J, Yuen H, Lai J . Use of sodium hyaluronate and indocyanine green for conjunctival cyst excision. Jpn J Ophthalmol. 2009; 53(3):270-1. DOI: 10.1007/s10384-008-0654-3. View

Le Corre A, Dot C, Feraoun M, Burelle X, Grasswill C, Perrenoud F . [Plateau iris-like configuration resulting from numerous iridociliary cysts]. J Fr Ophtalmol. 2009; 32(7):501-4. DOI: 10.1016/j.jfo.2009.04.023. View

Xiao Y, Wang Y, Niu G, Gao M . Primary iris stromal cyst with rapid growth. Optom Vis Sci. 2009; 86(11):E1309-12. DOI: 10.1097/OPX.0b013e3181bb4243. View

See J . Imaging of the anterior segment in glaucoma. Clin Exp Ophthalmol. 2009; 37(5):506-13. DOI: 10.1111/j.1442-9071.2009.02081.x. View

Ursea R, Silverman R . Anterior-segment imaging for assessment of glaucoma. Expert Rev Ophthalmol. 2010; 5(1):59-74. PMC: 2839239. DOI: 10.1586/eop.09.61. View

Ishikawa H, Liebmann J, Ritch R . Quantitative assessment of the anterior segment using ultrasound biomicroscopy. Curr Opin Ophthalmol. 2000; 11(2):133-9. DOI: 10.1097/00055735-200004000-00012. View

Grutzmacher R, Lindquist T, Chittum M, KALINA R . Congenital iris cysts. Br J Ophthalmol. 1987; 71(3):227-34. PMC: 1041126. DOI: 10.1136/bjo.71.3.227. View

Console J, Sakata L, Aung T, Friedman D, He M . Quantitative analysis of anterior segment optical coherence tomography images: the Zhongshan Angle Assessment Program. Br J Ophthalmol. 2008; 92(12):1612-6. DOI: 10.1136/bjo.2007.129932. View

Nolan W . Anterior segment imaging: ultrasound biomicroscopy and anterior segment optical coherence tomography. Curr Opin Ophthalmol. 2008; 19(2):115-21. DOI: 10.1097/ICU.0b013e3282f40bba. View

10.

Sihota R, Dada T, Aggarwal A, Srinivasan G, Gupta V, Chabra V . Does an iridotomy provide protection against narrowing of the anterior chamber angle during Valsalva maneuvre in eyes with primary angle closure. Eye (Lond). 2007; 22(3):389-93. DOI: 10.1038/sj.eye.6702646. View

11.

Chou C, Jordan C, McGhee C, Patel D . Comparison of intraocular pressure measurement using 4 different instruments following penetrating keratoplasty. Am J Ophthalmol. 2011; 153(3):412-8. DOI: 10.1016/j.ajo.2011.08.020. View

12.

Shin H, Subrayan V, Tajunisah I . Changes in anterior chamber depth and intraocular pressure after phacoemulsification in eyes with occludable angles. J Cataract Refract Surg. 2010; 36(8):1289-95. DOI: 10.1016/j.jcrs.2010.02.024. View

13.

Pavlin C, Foster F . Plateau iris syndrome: changes in angle opening associated with dark, light, and pilocarpine administration. Am J Ophthalmol. 1999; 128(3):288-91. DOI: 10.1016/s0002-9394(99)00149-x. View

14.

Donate D, Kodjikian L, Gambrelle J, Burillon C, Denis P . [Buphthalmia secondary to congenital pigmented epithelial iris cyst]. J Fr Ophtalmol. 2004; 27(5):496-500. DOI: 10.1016/s0181-5512(04)96170-0. View

15.

Honda N, Mimura T, Hotehama A, Usui T, Sugisaki K, Fukuoka S . Laser treatment of giant iris cyst with nanophthalmos. Int Ophthalmol. 2010; 31(1):17-20. DOI: 10.1007/s10792-010-9385-9. View

16.

Krohn J, Hove V . Recurring iris pigment epithelial cyst induced by topical prostaglandin F2 alpha analogues. Arch Ophthalmol. 2008; 126(6):867-8. DOI: 10.1001/archopht.126.6.867. View

17.

Mansouri K, Sommerhalder J, Shaarawy T . Prospective comparison of ultrasound biomicroscopy and anterior segment optical coherence tomography for evaluation of anterior chamber dimensions in European eyes with primary angle closure. Eye (Lond). 2009; 24(2):233-9. DOI: 10.1038/eye.2009.103. View

18.

Baykara M, Sahin S, Erturk H . Free iris cyst in the anterior chamber. Ophthalmic Surg Lasers Imaging. 2004; 35(1):74-5. View

19.

Alward W, Ossoinig K . Pigment dispersion secondary to cysts of the iris pigment epithelium. Arch Ophthalmol. 1995; 113(12):1574-5. DOI: 10.1001/archopht.1995.01100120106024. View

20.

Buchwald H, Spraul C, Wagner P, Lang G . [Ultrasound biomicroscopy in iris lesions]. Ophthalmologe. 1999; 96(2):108-13. DOI: 10.1007/s003470050384. View