Breast Cancer Adaptive Resistance: HER2 and Cancer Stem Cell Repopulation in a Heterogeneous Tumor Society

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 2013 Aug 31

PMID 23990015

Citations 29

Authors

Nadire Duru

Demet Candas

Guochun Jiang

Jian Jian Li

Affiliations

Soon will be listed here.

Abstract

Purpose: The lethal effects of cancer are associated with the enhanced tumor aggressiveness in recurrent and metastatic lesions that show resistant phenotype to anti-cancer therapy, a major barrier to improving overall survival of cancer patients. The presence of heterogeneous populations of cancer cells within a specific tumor including the tumor-initiating cells or so-called cancer stem cells (CSCs) has linked the acquired resistance (AR, or adaptive resistance). Herein, we discuss the CSC-mediated tumor repopulation in AR of breast cancer in this review.

Methods: We emphasize a dynamic feature of gene induction in tumor cells that undergo long-term treatment, and describe a specific HER2-NF-κB-HER2 pro-survival pathway that can be initiated in breast CSCs upon radiation therapy.

Results: Elucidation of HER2-induced pro-survival networks, specifically the force driving tumor repopulation due to radioresistant CSCs during anticancer therapies, will have a significant impact on the generation of new diagnostic and therapeutic targets to control of recurrent and metastatic breast tumors.

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