Intersectin: The Crossroad Between Vesicle Exocytosis and Endocytosis

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2013 Aug 30

PMID 23986746

Citations 19

Authors

Olga Gubar

Dmytro Morderer

Lyudmila Tsyba

Pauline Croise

Sebastien Houy

Stephane Ory

Stephane Gasman

Alla Rynditch

Affiliations

Soon will be listed here.

Abstract

Intersectins (ITSNs) are a family of highly conserved proteins with orthologs from nematodes to mammals. In vertebrates, ITSNs are encoded by two genes (itsn1 and itsn2), which act as scaffolds that were initially discovered as proteins involved in endocytosis. Further investigation demonstrated that ITSN1 is also implicated in several other processes including regulated exocytosis, thereby suggesting a role for ITSN1 in the coupling between exocytosis and endocytosis in excitatory cells. Despite a high degree of conservation amongst orthologs, ITSN function is not so well preserved as they have acquired new properties during evolution. In this review, we will discuss the role of ITSN1 and its orthologs in exo- and endocytosis, in particular in neurons and neuroendocrine cells.

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