High-density Lipoprotein and Prostate Cancer: an Overview

Overview

Journal J Epidemiol

Specialty Public Health

Date 2013 Aug 30

PMID 23985823

Citations 28

Authors

Kazuhiko Kotani

Yoshitaka Sekine

Shizukiyo Ishikawa

Imoh Z Ikpot

Kazuhiro Suzuki

Alan T Remaley

Affiliations

Soon will be listed here.

Abstract

Prostate cancer is a common disease in modern, developed societies and has a high incidence and mortality. High-density lipoprotein cholesterol (HDL-C) has recently received much attention as a possible risk marker of prostate cancer development and prognosis. In the present article, we summarized findings from epidemiologic studies of the association between HDL-C and prostate cancer. Low HDL-C level was found to be a risk and prognostic factor of prostate cancer in several epidemiologic studies, although the overall linkage between HDL and prostate cancer has not been definitively established. The mechanisms for this association remain uncertain; however, limited data from experimental studies imply a possible role of HDL in the pathophysiology of prostate cancer. More epidemiologic research, in combination with experimental studies, is needed in this field.

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