Relationship Between Vitamin D Receptor Gene Polymorphisms and Migraine Without Aura in an Iranian Population

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2013 Aug 29

PMID 23984350

Citations 15

Authors

Mohammad Motaghi

Shaghayegh Haghjooy Javanmard

Faraidoon Haghdoost

Mohamadhasan Tajadini

Mohammad Saadatnia

Laleh Rafiee

Alireza Zandifar

Affiliations

Soon will be listed here.

Abstract

Background: Inflammation has a key role in migraine pathophysiology. Vitamin D is an effective anti-inflammatory agent. The aim of this study was to investigate the association between migraine and two vitamin D receptor (VDR) polymorphisms (TaqI and FokI) and also the relationship between VDR polymorphisms and headache severity.

Methods: In this case-control study we assessed 103 patients with newly diagnosed migraine without aura and 100 healthy subjects. Patients filled headache impact test-6 (HIT-6) as a tool to assess headache severity.

Results: Genotype frequencies of VDR were significantly different between control and migraine patients. Heterozygote genotypes (Ff and Tt) were statistically more frequent in the migraine patients than the control subjects both for TaqI gene (P = 0.018; OR = 1.81, 95% CI = 1.03-3.18) and FokI gene polymorphisms (P = 0.001; OR = 2.91, 95% CI = 1.47-5.77). Also f and t alleles were more frequent in the migraine patients. Total HIT-6 score was significantly different between FokI heterozygote and homozygote patients (60.32 ± 1.87 versus 49.87 ± 2.69, resp., P = 0.004).

Conclusions: In conclusion our results showed that TaqI and FokI gene polymorphisms are associated with migraine without aura in Iranians patients. Also headache severity in FokI heterozygote patients was significantly greater than in the homozygote patients.

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References

Huang J, Xie Z . Polymorphisms in the vitamin D receptor gene and multiple sclerosis risk: a meta-analysis of case-control studies. J Neurol Sci. 2011; 313(1-2):79-85. DOI: 10.1016/j.jns.2011.09.024. View

Naderi N, Farnood A, Habibi M, Derakhshan F, Balaii H, Motahari Z . Association of vitamin D receptor gene polymorphisms in Iranian patients with inflammatory bowel disease. J Gastroenterol Hepatol. 2008; 23(12):1816-22. DOI: 10.1111/j.1440-1746.2008.05525.x. View

Lee S, Chu K, Jung K, Kim D, Kim E, Choe V . Decreased number and function of endothelial progenitor cells in patients with migraine. Neurology. 2008; 70(17):1510-7. DOI: 10.1212/01.wnl.0000294329.93565.94. View

Cao S, Luo P, Li W, Tang W, Cong X, Wei P . Vitamin D receptor genetic polymorphisms and tuberculosis among Chinese Han ethnic group. Chin Med J (Engl). 2012; 125(5):920-5. View

Straube S, Moore R, Derry S, McQuay H . Vitamin D and chronic pain. Pain. 2008; 141(1-2):10-3. DOI: 10.1016/j.pain.2008.11.010. View

Ghosh J, Joshi G, Pradhan S, Mittal B . Investigation of TNFA 308G > A and TNFB 252G > A polymorphisms in genetic susceptibility to migraine. J Neurol. 2009; 257(6):898-904. DOI: 10.1007/s00415-009-5430-x. View

Kesby J, Cui X, Ko P, McGrath J, Burne T, Eyles D . Developmental vitamin D deficiency alters dopamine turnover in neonatal rat forebrain. Neurosci Lett. 2009; 461(2):155-8. DOI: 10.1016/j.neulet.2009.05.070. View

Yilmaz I, Ozge A, Erdal M, Edgunlu T, Cakmak S, Yalin O . Cytokine polymorphism in patients with migraine: some suggestive clues of migraine and inflammation. Pain Med. 2010; 11(4):492-7. DOI: 10.1111/j.1526-4637.2009.00791.x. View

Wang Q, Xi B, Reilly K, Liu M, Fu M . Quantitative assessment of the associations between four polymorphisms (FokI, ApaI, BsmI, TaqI) of vitamin D receptor gene and risk of diabetes mellitus. Mol Biol Rep. 2012; 39(10):9405-14. DOI: 10.1007/s11033-012-1805-7. View

10.

Yiu Y, Chan Y, Yiu K, Siu C, Li S, Wong L . Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. J Clin Endocrinol Metab. 2011; 96(5):E830-5. DOI: 10.1210/jc.2010-2212. View

11.

Lehmann D, Refsum H, Warden D, Medway C, Wilcock G, Smith A . The vitamin D receptor gene is associated with Alzheimer's disease. Neurosci Lett. 2011; 504(2):79-82. DOI: 10.1016/j.neulet.2011.08.057. View

12.

Gu L, Yan Y, Long J, Su L, Hu Y, Chen Q . The TNF-α-308G/A polymorphism is associated with migraine risk: A meta-analysis. Exp Ther Med. 2012; 3(6):1082-1086. PMC: 3438673. DOI: 10.3892/etm.2012.533. View

13.

Prakash S, Shah N . Chronic tension-type headache with vitamin D deficiency: casual or causal association?. Headache. 2009; 49(8):1214-22. DOI: 10.1111/j.1526-4610.2009.01483.x. View

14.

Vos T, Flaxman A, Naghavi M, Lozano R, Michaud C, Ezzati M . Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012; 380(9859):2163-96. PMC: 6350784. DOI: 10.1016/S0140-6736(12)61729-2. View

15.

Simmons J, Mullighan C, Welsh K, Jewell D . Vitamin D receptor gene polymorphism: association with Crohn's disease susceptibility. Gut. 2000; 47(2):211-4. PMC: 1728007. DOI: 10.1136/gut.47.2.211. View

16.

Schreiber C . The pathophysiology of migraine. Dis Mon. 2006; 52(10):385-401. DOI: 10.1016/j.disamonth.2006.09.003. View

17.

Kosinski M, Bayliss M, Bjorner J, Ware Jr J, Garber W, Batenhorst A . A six-item short-form survey for measuring headache impact: the HIT-6. Qual Life Res. 2003; 12(8):963-74. DOI: 10.1023/a:1026119331193. View

18.

. Alleviation of migraines with therapeutic vitamin D and calcium. Headache. 1994; 34(10):590-2. DOI: 10.1111/j.1526-4610.1994.hed3410590.x. View

19.

Kjaergaard M, Eggen A, Mathiesen E, Jorde R . Association between headache and serum 25-hydroxyvitamin D: the Tromsø Study: Tromsø 6. Headache. 2012; 52(10):1499-505. DOI: 10.1111/j.1526-4610.2012.02250.x. View

20.

Jablonski K, Chonchol M, Pierce G, Walker A, Seals D . 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults. Hypertension. 2010; 57(1):63-9. PMC: 3020150. DOI: 10.1161/HYPERTENSIONAHA.110.160929. View