Preserved Transcallosal Inhibition to Transcranial Magnetic Stimulation in Nondemented Elderly Patients with Leukoaraiosis

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2013 Aug 29

PMID 23984349

Citations 32

Authors

Giuseppe Lanza

Rita Bella

Salvatore Giuffrida

Mariagiovanna Cantone

Giovanni Pennisi

Concetto Spampinato

Daniela Giordano

Giulia Malaguarnera

Alberto Raggi

Manuela Pennisi

Affiliations

Soon will be listed here.

Abstract

Structural corpus callosum (CC) changes in patients with leukoaraiosis (LA) are significantly associated with cognitive and motor impairment. The aim of this study is to investigate the transcallosal fibers functioning by means of transcranial magnetic stimulation (TMS) in elderly patients with LA. The resting motor threshold (rMT), the motor-evoked potentials (MEPs), and the controlateral (cSP) and ipsilateral silent periods (iSP) were determined using single-pulse TMS in 15 patients and 15 age-matched controls. The neuropsychological profile and the vascular burden at brain magnetic resonance imaging (MRI) were concomitantly explored. Patients reported abnormal scores at tests evaluating executive control functions. No significant difference was found in TMS measures of intra- and intercortical excitability. No CC lesion was evident at MRI. Transcallosal inhibitory mechanisms to TMS seem to be spared in LA patients, a finding which is in line with neuroimaging features and suggests a functional integrity of the CC despite the ischemic interruption of corticosubcortical loops implicated in cognition and behavior. The observed neurophysiological finding differs from that reported in degenerative dementia, even in the preclinical or early stage. In our group of patients, the pure extent of LA is more related to impairment of frontal lobe abilities rather than functional callosal changes.

Citing Articles

Editorial: Application of noninvasive neuromodulation in cognitive rehabilitation.

Wei P, Li L, Lanza G, Cantone M, Gu P Front Neurol. 2023; 14:1333474.

PMID: 38130838 PMC: 10733538. DOI: 10.3389/fneur.2023.1333474.

Current perspectives on prevention of vascular cognitive impairment and promotion of vascular brain health.

Kalaria R, Akinyemi R, Paddick S, Ihara M Expert Rev Neurother. 2023; 24(1):25-44.

PMID: 37916306 PMC: 10872925. DOI: 10.1080/14737175.2023.2273393.

Sex-specific reference values for total, central, and peripheral latency of motor evoked potentials from a large cohort.

Cantone M, Lanza G, Fisicaro F, Bella R, Ferri R, Pennisi G Front Hum Neurosci. 2023; 17:1152204.

PMID: 37362949 PMC: 10288153. DOI: 10.3389/fnhum.2023.1152204.

Challenging the Pleiotropic Effects of Repetitive Transcranial Magnetic Stimulation in Geriatric Depression: A Multimodal Case Series Study.

Nicoletti V, Fisicaro F, Aguglia E, Bella R, Calcagno D, Cantone M Biomedicines. 2023; 11(3).

PMID: 36979937 PMC: 10046045. DOI: 10.3390/biomedicines11030958.

Sex differences in mild vascular cognitive impairment: A multimodal transcranial magnetic stimulation study.

Cantone M, Fisicaro F, Ferri R, Bella R, Pennisi G, Lanza G PLoS One. 2023; 18(3):e0282751.

PMID: 36867595 PMC: 9983846. DOI: 10.1371/journal.pone.0282751.

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