The Controversial Role of Microglia in Malignant Gliomas

Overview

Journal Clin Dev Immunol

Specialty Allergy & Immunology

Date 2013 Aug 29

PMID 23983766

Citations 120

Authors

Jun Wei

Konrad Gabrusiewicz

Amy Heimberger

Affiliations

Soon will be listed here.

Abstract

Malignant gliomas contain stroma and a variety of immune cells including abundant activated microglia/macrophages. Mounting evidence indicates that the glioma microenvironment converts the glioma-associated microglia/macrophages (GAMs) into glioma-supportive, immunosuppressive cells; however, GAMs can retain intrinsic anti-tumor properties. Here, we review and discuss this duality and the potential therapeutic strategies that may inhibit their glioma-supportive and propagating functions.

Citing Articles

Developmental-status-aware transcriptional decomposition establishes a cell state panorama of human cancers.

Luo Y, Liang H Genome Med. 2024; 16(1):124.

PMID: 39468667 PMC: 11514945. DOI: 10.1186/s13073-024-01393-6.

The two-sided battlefield of tumour-associated macrophages in glioblastoma: unravelling their therapeutic potential.

Xiong J, Zhou X, Su L, Jiang L, Ming Z, Pang C Discov Oncol. 2024; 15(1):590.

PMID: 39453528 PMC: 11511804. DOI: 10.1007/s12672-024-01464-5.

Necroptosis-based glioblastoma prognostic subtypes: implications for TME remodeling and therapy response.

Khan M, Huang X, Ye X, Zhang D, Wang B, Xu A Ann Med. 2024; 56(1):2405079.

PMID: 39387496 PMC: 11469424. DOI: 10.1080/07853890.2024.2405079.

Lipid metabolic rewiring in glioma‑associated microglia/macrophages (Review).

Ma Y, Huang Y, Hu F, Shu K Int J Mol Med. 2024; 54(5).

PMID: 39301636 PMC: 11414527. DOI: 10.3892/ijmm.2024.5426.

Phagocytosis Checkpoints in Glioblastoma: CD47 and Beyond.

Afzal A, Afzal Z, Bizink S, Davis A, Makahleh S, Mohamed Y Curr Issues Mol Biol. 2024; 46(8):7795-7811.

PMID: 39194679 PMC: 11352848. DOI: 10.3390/cimb46080462.

References

Fulci G, Breymann L, Gianni D, Kurozomi K, Rhee S, Yu J . Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses. Proc Natl Acad Sci U S A. 2006; 103(34):12873-8. PMC: 1568940. DOI: 10.1073/pnas.0605496103. View

Meyers P, Schwartz C, Krailo M, Healey J, Bernstein M, Betcher D . Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival--a report from the Children's Oncology Group. J Clin Oncol. 2008; 26(4):633-8. DOI: 10.1200/JCO.2008.14.0095. View

Bao S, Wu Q, McLendon R, Hao Y, Shi Q, Hjelmeland A . Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006; 444(7120):756-60. DOI: 10.1038/nature05236. View

Kennedy B, Maier L, DAmico R, Mandigo C, Fontana E, Waziri A . Dynamics of central and peripheral immunomodulation in a murine glioma model. BMC Immunol. 2009; 10:11. PMC: 2654428. DOI: 10.1186/1471-2172-10-11. View

Badie B, Schartner J . Flow cytometric characterization of tumor-associated macrophages in experimental gliomas. Neurosurgery. 2000; 46(4):957-61; discussion 961-2. DOI: 10.1097/00006123-200004000-00035. View

Gabrusiewicz K, Ellert-Miklaszewska A, Lipko M, Sielska M, Frankowska M, Kaminska B . Characteristics of the alternative phenotype of microglia/macrophages and its modulation in experimental gliomas. PLoS One. 2011; 6(8):e23902. PMC: 3162015. DOI: 10.1371/journal.pone.0023902. View

Trehin R, Figueiredo J, Pittet M, Weissleder R, Josephson L, Mahmood U . Fluorescent nanoparticle uptake for brain tumor visualization. Neoplasia. 2006; 8(4):302-11. PMC: 1600680. DOI: 10.1593/neo.05751. View

Zhang L, Alizadeh D, Van Handel M, Kortylewski M, Yu H, Badie B . Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice. Glia. 2009; 57(13):1458-67. DOI: 10.1002/glia.20863. View

Smyth M, Dunn G, Schreiber R . Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity. Adv Immunol. 2006; 90:1-50. DOI: 10.1016/S0065-2776(06)90001-7. View

10.

Ye X, Xu S, Xin Y, Yu S, Ping Y, Chen L . Tumor-associated microglia/macrophages enhance the invasion of glioma stem-like cells via TGF-β1 signaling pathway. J Immunol. 2012; 189(1):444-53. DOI: 10.4049/jimmunol.1103248. View

11.

Ghosh A, Mukherjee J, Bhattacharjee M, Sarkar P, Acharya S, Chaudhuri S . The other side of the coin: beneficiary effect of 'oxidative burst' upsurge with T11TS facilitates the elimination of glioma cells. Cell Mol Biol (Noisy-le-grand). 2007; 53(5):53-62. View

12.

Nitta T, Sato K, Allegretta M, Brocke S, Lim M, Mitchell D . Expression of granulocyte colony stimulating factor and granulocyte-macrophage colony stimulating factor genes in human astrocytoma cell lines and in glioma specimens. Brain Res. 1992; 571(1):19-25. DOI: 10.1016/0006-8993(92)90505-4. View

13.

Komohara Y, Ohnishi K, Kuratsu J, Takeya M . Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas. J Pathol. 2008; 216(1):15-24. DOI: 10.1002/path.2370. View

14.

Lodge P, Sriram S . Regulation of microglial activation by TGF-beta, IL-10, and CSF-1. J Leukoc Biol. 1996; 60(4):502-8. DOI: 10.1002/jlb.60.4.502. View

15.

da Fonseca A, Romao L, Amaral R, Assad Kahn S, Lobo D, Martins S . Microglial stress inducible protein 1 promotes proliferation and migration in human glioblastoma cells. Neuroscience. 2011; 200:130-41. DOI: 10.1016/j.neuroscience.2011.10.025. View

16.

Dutta T, Spence A, Lampson L . Robust ability of IFN-gamma to upregulate class II MHC antigen expression in tumor bearing rat brains. J Neurooncol. 2003; 64(1-2):31-44. DOI: 10.1007/BF02700018. View

17.

Doucette T, Kong L, Yang Y, Ferguson S, Yang J, Wei J . Signal transducer and activator of transcription 3 promotes angiogenesis and drives malignant progression in glioma. Neuro Oncol. 2012; 14(9):1136-45. PMC: 3424209. DOI: 10.1093/neuonc/nos139. View

18.

Wu A, Wei J, Kong L, Wang Y, Priebe W, Qiao W . Glioma cancer stem cells induce immunosuppressive macrophages/microglia. Neuro Oncol. 2010; 12(11):1113-25. PMC: 3098021. DOI: 10.1093/neuonc/noq082. View

19.

Deininger M, Meyermann R, Trautmann K, Duffner F, Grote E, Wickboldt J . Heme oxygenase (HO)-1 expressing macrophages/microglial cells accumulate during oligodendroglioma progression. Brain Res. 2000; 882(1-2):1-8. DOI: 10.1016/s0006-8993(00)02594-4. View

20.

Deininger M, Seid K, Engel S, Meyermann R, Schluesener H . Allograft inflammatory factor-1 defines a distinct subset of infiltrating macrophages/microglial cells in rat and human gliomas. Acta Neuropathol. 2000; 100(6):673-80. DOI: 10.1007/s004010000233. View