Wuchereria Bancrofti Transmission Pattern in Southern Mali Prior to and Following the Institution of Mass Drug Administration

Overview

Journal Parasit Vectors

Publisher Biomed Central

Specialties Parasitology
Tropical Medicine

Date 2013 Aug 29

PMID 23981378

Citations 11

Authors

Yaya Ibrahim Coulibaly

Benoit Dembele

Abdallah Amadou Diallo

Sibylle Kristensen

Siaka Konate

Housseini Dolo

Ilo Dicko

Moussa Brema Sangare

Falaye Keita

Boakye A Boatin

Abdel Kader Traore

Thomas B Nutman

Amy D Klion

Yeya Tiemoko Toure

Sekou Fantamady Traore

Affiliations

Soon will be listed here.

Abstract

Background: The Global Programme to Eliminate Lymphatic Filariasis (GPELF) was launched in 2000 with the goal of stopping transmission of lymphatic filariasis (LF) through yearly mass drug administration (MDA). Although preliminary surveys of the human population in Mali suggested that Wuchereria bancrofti infection was highly endemic in the Sikasso district, baseline entomological data were required to confirm high levels of transmission prior to the selection of villages in this region for a study of the impact of MDA on transmission of LF by anopheline vectors.

Methods: W. bancrofti transmission was assessed in 2001 (pre-MDA) and 2002 (post-MDA) in the Central District of Sikasso in southern Mali by dissection of Anopheles mosquitoes caught using the human landing catch (HLC) method. The relative frequencies and molecular forms of An. gambiae complex were determined.

Results: The majority (86%) of the anopheline vectors captured were identified as An. gambiae complex, and these accounted for >90% of the entomological inoculation rate (EIR) during both years of the study. There was a dramatic decrease in the number of An. gambiae complex mosquitoes captured and in the An. gambiae complex infectivity rates following MDA, accounting for the observed decrease in EIR in 2002 (from 12.55 to 3.79 infective bites per person during the transmission season). An. funestus complex mosquitoes were responsible for a low level of transmission, which was similar during both years of the study (1.2 infective bites per person during the transmission season in 2001 and 1.03 in 2002).

Conclusions: Based on the entomological data from this study, the district of Sikasso was confirmed as an area of high W. bancrofti transmission. This led to the selection of this area for a multi-national study on the effects of MDA on LF transmission by anopheline vectors. Comparison of vector transmission parameters prior to and immediately following the first round of MDA demonstrated a significant decrease in overall transmission. Importantly, the dramatic variability in EIR over the transmission season suggests that the efficacy of MDA can be maximized by delivering drug at the beginning of the rainy season (just prior to the peak of transmission).

Citing Articles

Lymphedema in three previously Wuchereria bancrofti-endemic health districts in Mali after cessation of mass drug administration.

Dolo H, Coulibaly Y, Konipo F, Coulibaly S, Doumbia S, Sangare M BMC Infect Dis. 2020; 20(1):48.

PMID: 31941448 PMC: 6964034. DOI: 10.1186/s12879-020-4777-6.

Assessing the Presence of Infections in Vectors Using Xenomonitoring in Lymphatic Filariasis Endemic Districts in Ghana.

Pi-Bansa S, Osei J, Kartey-Attipoe W, Elhassan E, Agyemang D, Otoo S Trop Med Infect Dis. 2019; 4(1).

PMID: 30884886 PMC: 6473662. DOI: 10.3390/tropicalmed4010049.

Mosquitoes (Diptera: Culicidae) and mosquito-borne diseases in Mali, West Africa.

Tandina F, Doumbo O, Yaro A, Traore S, Parola P, Robert V Parasit Vectors. 2018; 11(1):467.

PMID: 30103823 PMC: 6090629. DOI: 10.1186/s13071-018-3045-8.

A cross-sectional study of the filarial and Leishmania co-endemicity in two ecologically distinct settings in Mali.

Sangare M, Coulibaly Y, Coulibaly S, Coulibaly M, Traore B, Dicko I Parasit Vectors. 2018; 11(1):18.

PMID: 29310700 PMC: 5759231. DOI: 10.1186/s13071-017-2531-8.

Dynamics of antigenemia and transmission intensity of Wuchereria bancrofti following cessation of mass drug administration in a formerly highly endemic region of Mali.

Coulibaly Y, Coulibaly S, Dolo H, Konate S, Diallo A, Doumbia S Parasit Vectors. 2016; 9(1):628.

PMID: 27912789 PMC: 5135747. DOI: 10.1186/s13071-016-1911-9.

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