Precipitation of Calcium Phosphates from Electrolyte Solutions. III. Radiometric Studies of the Kinetics of Precipitation and Aging of Calcium Phosphates

Overview

Journal Calcif Tissue Res

Publisher Springer

Date 1975 Jul 4

PMID 239787

Citations 6

Authors

R Despotovic

N Filipovic-Vincekovic

H Furedi-Milhofer

Affiliations

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Abstract

Precipitation and precipitate transformation in the system sodium phosphate (pre-adjusted to pH 7.4)--calcium chloride (25 degrees) was studied by means of radiometric analysis using 45Ca and 32P as tracers. Changes in the pH and the total concentrations of calcium and phosphate were followed during solid phase formation and the data were used to calculate composition changes of the precipitates and their supernatants. In all investigated systems two-step precipitation was observed, the precursor being more basic than the secondary precipitate. The composition of the latter was mostly within the range of the composition of octacalcium phosphate. The course of further chemical changes was dependent on the pH established during secondary precipitation. The heterogeneous exchange of the radionuclides between the solid phase and their supernatant solutions was also followed as a function of time. The results indicate that recrystallization through the mother liquid accompanied by composition changes is the dominant mechanism of equilibrium of the solid phases.

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References

Pak C, Bartter F . Ionic interaction with bone mineral. I. Evidence for an isoionic calcium exchange with hydroxyapatite. Biochim Biophys Acta. 1967; 141(2):401-9. DOI: 10.1016/0304-4165(67)90115-8. View

Termine J, Peckauskas R, Posner A . Calcium phosphate formation in vitro. II. Effects of environment on amorphous-crystalline transformation. Arch Biochem Biophys. 1970; 140(2):318-25. DOI: 10.1016/0003-9861(70)90072-x. View

Francis M, Webb N . Hydroxyapatite formation from a hydrated calcium monohydrogen phosphate precursor. Calcif Tissue Res. 1971; 6(4):335-42. DOI: 10.1007/BF02196214. View

NEUMAN W, WEIKEL Jr J . Recrystallization in bone mineral. Ann N Y Acad Sci. 1955; 60(5):685-95. DOI: 10.1111/j.1749-6632.1955.tb40059.x. View

Termine J, Eanes E . Comparative chemistry of amorphous and apatitic calcium phosphate preparations. Calcif Tissue Res. 1972; 10(3):171-97. DOI: 10.1007/BF02012548. View

Eanes E, Gillessen I, Posner A . Intermediate states in the precipitation of hydroxyapatite. Nature. 1965; 208(5008):365-7. DOI: 10.1038/208365a0. View

DALLEMAGNE M, Bodson P, Fabry C . [Exchangeable calcium from the mineral substance of bone studied by means of radiocalcium]. Biochim Biophys Acta. 1955; 18(3):394-406. DOI: 10.1016/0006-3002(55)90103-7. View

Pak C, Skinner H . Ionic interaction with bone mineral. IV. Varying affinity of synthetic calcium phosphates for Ca2+. Biochim Biophys Acta. 1968; 165(2):274-82. DOI: 10.1016/0304-4165(68)90055-x. View

Brecevic L, Furedi-Milhofer H . Precipitation of calcium phosphates from electrolyte solutions. II. The formation and transformation of the precipitates. Calcif Tissue Res. 1972; 10(1):82-90. DOI: 10.1007/BF02012538. View

10.

Holmes J, BEEBE R . Surface areas by gas adsorption on amorphous calcium phosphate and crystalline hydroxyapatite. Calcif Tissue Res. 1971; 7(2):163-74. DOI: 10.1007/BF02062604. View

11.

Termine J, Posner A . Calcium phosphate formation in vitro. I. Factors affecting initial phase separation. Arch Biochem Biophys. 1970; 140(2):307-17. DOI: 10.1016/0003-9861(70)90071-8. View

12.

Best J . Some theoretical considerations concerning crystals with relevance to the physical properties of bone. Biochim Biophys Acta. 1959; 32(1):194-202. DOI: 10.1016/0006-3002(59)90569-4. View

13.

Furedi-Milhofer H, Purgaric B, Brecevic L, Pavkovic N . Precipitation of calcium phosphates from electrolyte solutions. I. Study of the precipitates in the physiological pH region. Calcif Tissue Res. 1971; 8(2):142-53. DOI: 10.1007/BF02010131. View

14.

SOBEL A, LAURENCE P . Crystal growth in mineralizing tissues. Biochim Biophys Acta. 1960; 41:1-8. DOI: 10.1016/0006-3002(60)90361-9. View