Interplay Between Autophagy and Programmed Cell Death in Mammalian Neural Stem Cells

Overview

Journal BMB Rep

Specialties Biochemistry
Molecular Biology

Date 2013 Aug 28

PMID 23977985

Citations 19

Authors

Kyung Min Chung

Seong-Woon Yu

Affiliations

Soon will be listed here.

Abstract

Mammalian neural stem cells (NSCs) are of particular interest because of their role in brain development and function. Recent findings suggest the intimate involvement of programmed cell death (PCD) in the turnover of NSCs. However, the underlying mechanisms of PCD are largely unknown. Although apoptosis is the best-defined form of PCD, accumulating evidence has revealed a wide spectrum of PCD encompassing apoptosis, autophagic cell death (ACD) and necrosis. This mini-review aims to illustrate a unique regulation of PCD in NSCs. The results of our recent studies on autophagic death of adult hippocampal neural stem (HCN) cells are also discussed. HCN cell death following insulin withdrawal clearly provides a reliable model that can be used to analyze the molecular mechanisms of ACD in the larger context of PCD. More research efforts are needed to increase our understanding of the molecular basis of NSC turnover under degenerating conditions, such as aging, stress and neurological diseases. Efforts aimed at protecting and harnessing endogenous NSCs will offer novel opportunities for the development of new therapeutic strategies for neuropathologies.

Citing Articles

The Yin and Yang dualistic features of autophagy in thermal burn wound healing.

Ripszky Totan A, Greabu M, Stanescu-Spinu I, Imre M, Spinu T, Miricescu D Int J Immunopathol Pharmacol. 2022; 36:3946320221125090.

PMID: 36121435 PMC: 9490459. DOI: 10.1177/03946320221125090.

Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects.

Huang W, Huang T, Liu Y, Fu J, Wei X, Liu D Cell Death Dis. 2021; 13(1):17.

PMID: 34930914 PMC: 8688449. DOI: 10.1038/s41419-021-04473-2.

Water Extract Presented the Possibility to Enhance Neuronal Regeneration.

Kantawong F, Saisuwan C, Soeratanapant P, Wanachantararak P, Nan J, Wu J Evid Based Complement Alternat Med. 2021; 2021:8818618.

PMID: 33680064 PMC: 7904343. DOI: 10.1155/2021/8818618.

Autophagy as a decisive process for cell death.

Jung S, Jeong H, Yu S Exp Mol Med. 2020; 52(6):921-930.

PMID: 32591647 PMC: 7338414. DOI: 10.1038/s12276-020-0455-4.

Dose in Brain Development.

Hettige N, Ernst C Front Pediatr. 2019; 7:482.

PMID: 31824897 PMC: 6882862. DOI: 10.3389/fped.2019.00482.

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