Increased Risk of Acute Pancreatitis in Patients with Chronic Hemodialysis: a 4-year Follow-up Study

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Aug 27

PMID 23977145

Citations 14

Authors

Sheng-Wen Hou

Yi-Kung Lee

Chen-Yang Hsu

Ching-Chih Lee

Yung-Cheng Su

Affiliations

Soon will be listed here.

Abstract

Background: The risk of acute pancreatitis in patients on long-term peritoneal dialysis is higher as compared to the general population. However, the relationship between long-term hemodialysis and acute pancreatitis has never been established.

Objectives: We investigated the incidence of acute pancreatitis among patients on long-term hemodialysis in Taiwan to evaluate if there is a higher risk of acute pancreatitis in comparison to the general population.

Methods: We utilized a National Health Insurance (NHI) claims data sample containing one million beneficiaries. We followed all adult beneficiaries from January 1, 2007 until December 31, 2010 to see if they had been hospitalized for acute pancreatitis during this period. We further identified patients on chronic hemodialysis and compared their risk of acute pancreatitis with the general population.

Results: This study included 2603 patients with long-term hemodialysis and 773,140 patients without hemodialysis. After controlling for age, gender, Charlson Comorbidity Index Score, geographic region, socioeconomic status and urbanization level, the adjusted hazard ratio was 3.44 (95% Confidence interval, 2.5-4.7).

Conclusions: The risk of acute pancreatitis in patients on long-term hemodialysis is significantly higher in comparison to the general population.

Citing Articles

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Dumnicka P, Mazur-Laskowska M, Ceranowicz P, Sporek M, Kolber W, Tisonczyk J J Clin Med. 2022; 11(20).

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Syren E, Eriksson S, Enochsson L, Eklund A, Sandblom G BJS Open. 2019; 3(4):485-489.

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References

Bruno M, van Westerloo D, van Dorp W, Dekker W, Ferwerda J, Tytgat G . Acute pancreatitis in peritoneal dialysis and haemodialysis: risk, clinical course, outcome, and possible aetiology. Gut. 2000; 46(3):385-9. PMC: 1727868. DOI: 10.1136/gut.46.3.385. View

Manga F, Lim C, Mangena L, Guest M . Acute pancreatitis in peritoneal dialysis: a case report with literature review. Eur J Gastroenterol Hepatol. 2011; 24(1):95-101. DOI: 10.1097/MEG.0b013e32834d4bcc. View

Shen H, Lu C, Li C . Effect of diabetes on severity and hospital mortality in patients with acute pancreatitis: a national population-based study. Diabetes Care. 2012; 35(5):1061-6. PMC: 3329843. DOI: 10.2337/dc11-1925. View

Sirinek K, ODorisio T, GASKILL H, Levine B . Chronic renal failure: effect of hemodialysis on gastrointestinal hormones. Am J Surg. 1984; 148(6):732-5. DOI: 10.1016/0002-9610(84)90426-4. View

Charlson M, Pompei P, Ales K, MacKenzie C . A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987; 40(5):373-83. DOI: 10.1016/0021-9681(87)90171-8. View

Lankisch P, Weber-Dany B, Maisonneuve P, Lowenfels A . Frequency and severity of acute pancreatitis in chronic dialysis patients. Nephrol Dial Transplant. 2007; 23(4):1401-5. DOI: 10.1093/ndt/gfm769. View

Owyang C, Miller L, DiMagno E, Mitchell 3rd J, Go V . Pancreatic exocrine function in severe human chronic renal failure. Gut. 1982; 23(5):357-61. PMC: 1419670. DOI: 10.1136/gut.23.5.357. View

Shen H, Lu C, Li C . Epidemiology of first-attack acute pancreatitis in Taiwan from 2000 through 2009: a nationwide population-based study. Pancreas. 2012; 41(5):696-702. DOI: 10.1097/MPA.0b013e31823db941. View

Chang C, Su Y, Lai N, Huang K, Chien S, Chang Y . The combined effect of individual and neighborhood socioeconomic status on cancer survival rates. PLoS One. 2012; 7(8):e44325. PMC: 3431308. DOI: 10.1371/journal.pone.0044325. View

10.

Sachs E, Hurwitz F, Bloch H, Milne F . Pancreatic exocrine hypofunction in the wasting syndrome of end-stage renal disease. Am J Gastroenterol. 1983; 78(3):170-3. View

11.

Chiang T . Taiwan's 1995 health care reform. Health Policy. 1997; 39(3):225-39. DOI: 10.1016/s0168-8510(96)00877-9. View

12.

Schneeweiss S . Sensitivity analysis and external adjustment for unmeasured confounders in epidemiologic database studies of therapeutics. Pharmacoepidemiol Drug Saf. 2006; 15(5):291-303. DOI: 10.1002/pds.1200. View

13.

Deyo R, Cherkin D, Ciol M . Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992; 45(6):613-9. DOI: 10.1016/0895-4356(92)90133-8. View

14.

Araki T, Ueda M, Ogawa K, Tsuji T . Histological pancreatitis in end-stage renal disease. Int J Pancreatol. 1992; 12(3):263-9. DOI: 10.1007/BF02924366. View

15.

Lee Y, Hou S, Lee C, Hsu C, Huang Y, Su Y . Increased risk of dementia in patients with mild traumatic brain injury: a nationwide cohort study. PLoS One. 2013; 8(5):e62422. PMC: 3641064. DOI: 10.1371/journal.pone.0062422. View

16.

Vaziri N, Miller R, Mirahmadi M . Pancreatic pathology in chronic dialysis patients--an autopsy study of 78 cases. Nephron. 1987; 46(4):347-9. DOI: 10.1159/000184387. View

17.

Lee Y, Lee C, Chen C, Wong C, Su Y . High risk of 'failure' among emergency physicians compared with other specialists: a nationwide cohort study. Emerg Med J. 2013; 30(8):620-2. PMC: 3717584. DOI: 10.1136/emermed-2012-201440. View

18.

Quraishi E, Goel S, Gupta M, Catanzaro A, Zasuwa G, Divine G . Acute pancreatitis in patients on chronic peritoneal dialysis: an increased risk?. Am J Gastroenterol. 2005; 100(10):2288-93. DOI: 10.1111/j.1572-0241.2005.41646.x. View