Somatostatin--both Hormone and Neurotransmitter?

Overview

Journal Diabetologia

Specialty Endocrinology

Date 1978 Jan 14

PMID 23977

Citations 25

Authors

R Luft

S Efendic

T Hokfelt

Affiliations

Soon will be listed here.

Citing Articles

The Cells of the Islets of Langerhans.

da Silva Xavier G J Clin Med. 2018; 7(3).

PMID: 29534517 PMC: 5867580. DOI: 10.3390/jcm7030054.

Pancreatic α-Cell Dysfunction in Type 2 Diabetes: Old Kids on the Block.

Moon J, Won K Diabetes Metab J. 2015; 39(1):1-9.

PMID: 25729706 PMC: 4342530. DOI: 10.4093/dmj.2015.39.1.1.

Glucagon and type 2 diabetes: the return of the alpha cell.

Lund A, Bagger J, Christensen M, Knop F, Vilsboll T Curr Diab Rep. 2014; 14(12):555.

PMID: 25344790 DOI: 10.1007/s11892-014-0555-4.

Perinatal stress, brain inflammation and risk of autism-review and proposal.

Angelidou A, Asadi S, Alysandratos K, Karagkouni A, Kourembanas S, Theoharides T BMC Pediatr. 2012; 12:89.

PMID: 22747567 PMC: 3496584. DOI: 10.1186/1471-2431-12-89.

Delayed onset of hyperglycaemia in a mouse model with impaired glucagon secretion demonstrates that dysregulated glucagon secretion promotes hyperglycaemia and type 2 diabetes.

Gustavsson N, Seah T, Lao Y, Radda G, Sudhof T, Han W Diabetologia. 2010; 54(2):415-22.

PMID: 20978738 DOI: 10.1007/s00125-010-1950-2.

References

Gerich J, Lorenzi M, Schneider V, FORSHAM P . Effect of somatostatin on plasma glucose and insulin responses to glucagon and tolbutamide in man. J Clin Endocrinol Metab. 1974; 39(6):1057-60. DOI: 10.1210/jcem-39-6-1057. View

Yen S, Siler T, DeVane G . Effect of somatostatin in patients with acromegaly: suppression of growth hormone, prolactin, insulin and glucose levels. N Engl J Med. 1974; 290(17):935-8. DOI: 10.1056/NEJM197404252901704. View

Terenius L . Somatostatin and ACTH are peptides with partial antagonist-like selectivity for opiate receptors. Eur J Pharmacol. 1976; 38(1):211-3. DOI: 10.1016/0014-2999(76)90221-1. View

Claro A, Grill V, Efendic S, Luft R . Studies on the mechanisms of somatostatin action on insulin release. IV. effect of somatostatin on cyclic AMP levels and phosphodiesterase activity in isolated rat pancreatic islets. Acta Endocrinol (Copenh). 1977; 85(2):379-88. View

Rezek M, Havlicek V, Hughes K, Friesen H . Central site of action of somatostatin (SRIF): role of hippocampus. Neuropharmacology. 1976; 15(8):499-504. DOI: 10.1016/0028-3908(76)90062-9. View

Dubois M . Immunoreactive somatostatin is present in discrete cells of the endocrine pancreas. Proc Natl Acad Sci U S A. 1975; 72(4):1340-3. PMC: 432529. DOI: 10.1073/pnas.72.4.1340. View

Kato Y, Chihara K, Ogo S, Imura H . Effects of hypothalamic surgery and somatostatin on chlorpromazine-induced growth hormone release in rats. Endocrinology. 1974; 95(6):1608-13. DOI: 10.1210/endo-95-6-1608. View

Polak J, Pearse A, Grimelius L, Bloom S . Growth-hormone release-inhibiting hormone in gastrointestinal and pancreatic D cells. Lancet. 1975; 1(7918):1220-2. DOI: 10.1016/s0140-6736(75)92198-4. View

Alberti K, Christensen N, Christensen S, Hansen A, Iversen J, Lundbaek K . Inhibition of insulin secretion by somatostatin. Lancet. 1973; 2(7841):1299-301. DOI: 10.1016/s0140-6736(73)92873-0. View

10.

Wahren J, Efendic S, Luft R, Hagenfeldt L, Bjorkman O, FELIG P . Influence of somatostatin on splanchnic glucose metabolism in postabsorptive and 60-hour fasted humans. J Clin Invest. 1977; 59(2):299-307. PMC: 333360. DOI: 10.1172/JCI108641. View

11.

Efendic S, Claro A, Laft R . Studies on the mechanism of somatostatin action on insulin release. III. Effect of somatostatin on arginine induced release of insulin and glucagon in man and perfused rat pancreas. Acta Endocrinol (Copenh). 1976; 81(4):753-61. View

12.

Rufener C, Amherdt , Dubois M, Orci L . Letter: Ultrastructural immunocytochemical localization of somatostatin in rat pancreatic monolayer culture. J Histochem Cytochem. 1975; 23(11):866-9. DOI: 10.1177/23.11.1194672. View

13.

Uvnas-Wallensten K, Efendic S, Luft R . Inhibition of vagally induced gastrin release by somatostatin in cats. Horm Metab Res. 1977; 9(2):120-3. DOI: 10.1055/s-0028-1093558. View

14.

Kobberling J, Juppner H, Hesch R . The stimulation of growth hormone release by ACTH and its inhibition by somatostatin. Acta Endocrinol (Copenh). 1976; 81(2):263-9. DOI: 10.1530/acta.0.0810263. View

15.

Brownstein M, Saavedra J, Axelrod J, Zeman G, Carpenter D . Coexistence of several putative neurotransmitters in single identified neurons of Aplysia. Proc Natl Acad Sci U S A. 1974; 71(12):4662-5. PMC: 433955. DOI: 10.1073/pnas.71.12.4662. View

16.

Uvnas-Wallensten K, Efendic S, Luft R . Vagal release of somatostatin into the antral lumen of cats. Acta Physiol Scand. 1977; 99(1):126-8. DOI: 10.1111/j.1748-1716.1977.tb10362.x. View

17.

Barros dSa A, Bloom S, Baron J . Direct inhibition of gastric acid by growth-hormone release-inhibiting hormone in dogs. Lancet. 1975; 1(7912):886-7. DOI: 10.1016/s0140-6736(75)91685-2. View

18.

Konturek S, TASLER J, Obtulowicz W, Coy D, Schally A . Effect of growth hormone-release inhibiting hormone on hormones stimulating exocrine pancreatic secretion. J Clin Invest. 1976; 58(1):1-6. PMC: 333148. DOI: 10.1172/JCI108438. View

19.

Borgeat P, Labrie F, Drouin J, Belanger A, Immer H, Sestanj K . Inhibition of adenosine 3',5'-monophosphate accumulation in anterior pituitary gland in vitro by growth hormone-release inhibiting hormone. Biochem Biophys Res Commun. 1974; 56(4):1052-9. DOI: 10.1016/s0006-291x(74)80295-0. View

20.

Goldsmith P, Rose J, Arimura A, Ganong W . Ultrastructural localization of somatostatin in pancreatic islets of the rat. Endocrinology. 1975; 97(4):1061-4. DOI: 10.1210/endo-97-4-1061. View