Modulation of Oxidative Stress by Twist Oncoproteins

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Aug 23

PMID 23967308

Citations 9

Authors

Nicolas Floch

Jakub Kolodziejski

Leila Akkari

Yannick Simonin

Stephane Ansieau

Alain Puisieux

Urszula Hibner

Patrice Lassus

Affiliations

Soon will be listed here.

Abstract

Expression of developmental genes Twist1 and Twist2 is reactivated in many human tumors. Among their oncogenic activities, induction of epithelial to mesenchymal transition is believed to increase cell motility and invasiveness and may be related to acquisition of cancer stem cell phenotype. In addition, Twist proteins promote malignant conversion by overriding two oncogene-induced failsafe programs: senescence and apoptosis. Reactive oxygen species (ROS) are also important mediators of apoptosis, senescence and motility and are tightly linked to disease, notably to cancer. We report here that Twist factors and ROS are functionally linked. In wild type cells both Twist1 and Twist2 exhibit antioxidant properties. We show that Twist-driven modulation of oncogene-induced apoptosis is linked to its effects on oxidative stress. Finally, we identify several targets that mediate Twist antioxidant activity. These findings unveil a new function of Twist factors that could be important in explaining their pleiotropic role during carcinogenesis.

Citing Articles

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HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist.

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Twist1 Plays an Anti-apoptotic Role in Mutant Huntingtin Expression Striatal Progenitor Cells.

Jen W, Chen H, Lin Y, Chern Y, Lee Y Mol Neurobiol. 2019; 57(3):1688-1703.

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Reduced expression of Twist 1 is protective against insulin resistance of adipocytes and involves mitochondrial dysfunction.

Lu S, Wang H, Ren R, Shi X, Zhang Y, Ma W Sci Rep. 2018; 8(1):12590.

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