Making Scent of the Presence and Local Translation of Odorant Receptor MRNAs in Olfactory Axons

Overview

Journal Dev Neurobiol

Specialties Biology
Neurology

Date 2013 Aug 21

PMID 23959692

Citations 2

Authors

Caroline Dubacq

Coralie Fouquet

Alain Trembleau

Affiliations

Soon will be listed here.

Abstract

Rodents contain in their genome more than 1000 functional odorant receptor genes, which are specifically expressed by the olfactory sensory neurons projecting from the olfactory epithelium to the olfactory bulb. Strong evidence for the presence and local translation of odorant receptor mRNAs in the axon of olfactory sensory neurons was obtained, but no function has been assigned to these axonal mRNAs yet. The aim of this review is to discuss the evidence for the presence and local translation of odorant receptor mRNAs in olfactory sensory axons, and to speculate on their possible function in the wiring of the mouse olfactory sensory projections.

Citing Articles

Cell type-dependent axonal localization of translational regulators and mRNA in mouse peripheral olfactory neurons.

Korsak L, Shepard K, Akins M J Comp Neurol. 2017; 525(9):2202-2215.

PMID: 28266018 PMC: 5820109. DOI: 10.1002/cne.24199.

Homotypic and heterotypic adhesion induced by odorant receptors and the β2-adrenergic receptor.

Richard M, Jamet S, Fouquet C, Dubacq C, Boggetto N, Pincet F PLoS One. 2013; 8(12):e80100.

PMID: 24312457 PMC: 3846556. DOI: 10.1371/journal.pone.0080100.

References

Mohr E, Fehr S, Richter D . Axonal transport of neuropeptide encoding mRNAs within the hypothalamo-hypophyseal tract of rats. EMBO J. 1991; 10(9):2419-24. PMC: 452937. DOI: 10.1002/j.1460-2075.1991.tb07781.x. View

Andreassi C, Riccio A . To localize or not to localize: mRNA fate is in 3'UTR ends. Trends Cell Biol. 2009; 19(9):465-74. DOI: 10.1016/j.tcb.2009.06.001. View

Imai T, Suzuki M, Sakano H . Odorant receptor-derived cAMP signals direct axonal targeting. Science. 2006; 314(5799):657-61. DOI: 10.1126/science.1131794. View

Trembleau A, Melia K, Bloom F . BC1 RNA and vasopressin mRNA in rat neurohypophysis: axonal compartmentalization and differential regulation during dehydration and rehydration. Eur J Neurosci. 1995; 7(11):2249-60. DOI: 10.1111/j.1460-9568.1995.tb00646.x. View

Leung K, van Horck F, Lin A, Allison R, Standart N, Holt C . Asymmetrical beta-actin mRNA translation in growth cones mediates attractive turning to netrin-1. Nat Neurosci. 2006; 9(10):1247-56. PMC: 1997306. DOI: 10.1038/nn1775. View

Zou D, Chesler A, Le Pichon C, Kuznetsov A, Pei X, Hwang E . Absence of adenylyl cyclase 3 perturbs peripheral olfactory projections in mice. J Neurosci. 2007; 27(25):6675-83. PMC: 6672705. DOI: 10.1523/JNEUROSCI.0699-07.2007. View

Mombaerts P, Wang F, Dulac C, CHAO S, Nemes A, Mendelsohn M . Visualizing an olfactory sensory map. Cell. 1996; 87(4):675-86. DOI: 10.1016/s0092-8674(00)81387-2. View

Feinstein P, Mombaerts P . A contextual model for axonal sorting into glomeruli in the mouse olfactory system. Cell. 2004; 117(6):817-31. DOI: 10.1016/j.cell.2004.05.011. View

Dubacq C, Jamet S, Trembleau A . Evidence for developmentally regulated local translation of odorant receptor mRNAs in the axons of olfactory sensory neurons. J Neurosci. 2009; 29(33):10184-90. PMC: 6665787. DOI: 10.1523/JNEUROSCI.2443-09.2009. View

10.

Campbell D, Holt C . Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation. Neuron. 2002; 32(6):1013-26. DOI: 10.1016/s0896-6273(01)00551-7. View

11.

Maritan M, Monaco G, Zamparo I, Zaccolo M, Pozzan T, Lodovichi C . Odorant receptors at the growth cone are coupled to localized cAMP and Ca2+ increases. Proc Natl Acad Sci U S A. 2009; 106(9):3537-42. PMC: 2642662. DOI: 10.1073/pnas.0813224106. View

12.

Bozza T, Vassalli A, Fuss S, Zhang J, Weiland B, Pacifico R . Mapping of class I and class II odorant receptors to glomerular domains by two distinct types of olfactory sensory neurons in the mouse. Neuron. 2009; 61(2):220-33. PMC: 3013286. DOI: 10.1016/j.neuron.2008.11.010. View

13.

Andreassi C, Zimmermann C, Mitter R, Fusco S, De Vita S, Devita S . An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons. Nat Neurosci. 2010; 13(3):291-301. DOI: 10.1038/nn.2486. View

14.

Nedelec S, Dubacq C, Trembleau A . Morphological and molecular features of the mammalian olfactory sensory neuron axons: What makes these axons so special?. J Neurocytol. 2005; 34(1-2):49-64. DOI: 10.1007/s11068-005-5047-7. View

15.

Richard M, Taylor S, Greer C . Age-induced disruption of selective olfactory bulb synaptic circuits. Proc Natl Acad Sci U S A. 2010; 107(35):15613-8. PMC: 2932573. DOI: 10.1073/pnas.1007931107. View

16.

Mori K, Sakano H . How is the olfactory map formed and interpreted in the mammalian brain?. Annu Rev Neurosci. 2011; 34:467-99. DOI: 10.1146/annurev-neuro-112210-112917. View

17.

DROZ B, Leblond C . Migration of proteins along the axons of the sciatic nerve. Science. 1962; 137(3535):1047-8. DOI: 10.1126/science.137.3535.1047. View

18.

Zou D, Chesler A, Firestein S . How the olfactory bulb got its glomeruli: a just so story?. Nat Rev Neurosci. 2009; 10(8):611-8. DOI: 10.1038/nrn2666. View

19.

Mombaerts P . Axonal wiring in the mouse olfactory system. Annu Rev Cell Dev Biol. 2006; 22:713-37. DOI: 10.1146/annurev.cellbio.21.012804.093915. View

20.

Jirikowski G, Sanna P, Bloom F . mRNA coding for oxytocin is present in axons of the hypothalamo-neurohypophysial tract. Proc Natl Acad Sci U S A. 1990; 87(19):7400-4. PMC: 54754. DOI: 10.1073/pnas.87.19.7400. View