Nuclear Dynamics of Radiation-induced Foci in Euchromatin and Heterochromatin

Overview

Journal Mutat Res

Publisher Elsevier

Specialty Genetics

Date 2013 Aug 21

PMID 23958412

Citations 38

Authors

Irene Chiolo

Jonathan Tang

Walter Georgescu

Sylvain V Costes

Affiliations

Soon will be listed here.

Abstract

Repair of double strand breaks (DSBs) is essential for cell survival and genome integrity. While much is known about the molecular mechanisms involved in DSB repair and checkpoint activation, the roles of nuclear dynamics of radiation-induced foci (RIF) in DNA repair are just beginning to emerge. Here, we summarize results from recent studies that point to distinct features of these dynamics in two different chromatin environments: heterochromatin and euchromatin. We also discuss how nuclear architecture and chromatin components might control these dynamics, and the need of novel quantification methods for a better description and interpretation of these phenomena. These studies are expected to provide new biomarkers for radiation risk and new strategies for cancer detection and treatment.

Citing Articles

"Off-pore" nucleoporins relocalize heterochromatic breaks through phase separation.

Merigliano C, Ryu T, See C, Caridi C, Li X, Butova N bioRxiv. 2024; .

PMID: 39071440 PMC: 11275802. DOI: 10.1101/2023.12.07.570729.

Nup153 is not required for anchoring heterochromatic DSBs to the nuclear periphery.

Ryu T, Merigliano C, Chiolo I MicroPubl Biol. 2024; 2024.

PMID: 38737725 PMC: 11087819. DOI: 10.17912/micropub.biology.001176.

New Facets of DNA Double Strand Break Repair: Radiation Dose as Key Determinant of HR versus c-NHEJ Engagement.

Mladenov E, Mladenova V, Stuschke M, Iliakis G Int J Mol Sci. 2023; 24(19).

PMID: 37834403 PMC: 10573367. DOI: 10.3390/ijms241914956.

Nuclear Actin Dynamics in Gene Expression, DNA Repair, and Cancer.

Huang Y, Zhang S, Park J Results Probl Cell Differ. 2022; 70:625-663.

PMID: 36348125 PMC: 9677682. DOI: 10.1007/978-3-031-06573-6_23.

An Expanding Toolkit for Heterochromatin Repair Studies.

Rawal C, Butova N, Mitra A, Chiolo I Genes (Basel). 2022; 13(3).

PMID: 35328082 PMC: 8955653. DOI: 10.3390/genes13030529.

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