Probiotics As Additives on Therapy in Allergic Airway Diseases: a Systematic Review of Benefits and Risks

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2013 Aug 20

PMID 23956972

Citations 11

Authors

Rashmi Ranjan Das

Sushree Samiksha Naik

Meenu Singh

Affiliations

Soon will be listed here.

Abstract

Background: We conducted a systematic review to find out the role of probiotics in treatment of allergic airway diseases.

Methods: A comprehensive search of the major electronic databases was done till March 2013. Trials comparing the effect of probiotics versus placebo were included. A predefined set of outcome measures were assessed. Continuous data were expressed as standardized mean difference with 95% CI. Dichotomous data were expressed as odds ratio with 95% CI. P value < 0.05 was considered as significant.

Results: A total of 12 studies were included. Probiotic intake was associated with a significantly improved quality of life score in patients with allergic rhinitis (SMD -1.9 (95% CI -3.62, -0.19); P = 0.03), though there was a high degree of heterogeneity. No improvement in quality of life score was noted in asthmatics. Probiotic intake also improved the following parameters: longer time free from episodes of asthma and rhinitis and decrease in the number of episodes of rhinitis per year. Adverse events were not significant.

Conclusion: As the current evidence was generated from few trials with high degree of heterogeneity, routine use of probiotics as an additive on therapy in subjects with allergic airway diseases cannot be recommended.

Citing Articles

Probiotics in Children with Asthma.

Ciprandi G, Tosca M Children (Basel). 2022; 9(7).

PMID: 35883962 PMC: 9316460. DOI: 10.3390/children9070978.

Pediatric Obesity-Related Asthma: The Role of Nutrition and Nutrients in Prevention and Treatment.

Calcaterra V, Verduci E, Ghezzi M, Cena H, Pascuzzi M, Regalbuto C Nutrients. 2021; 13(11).

PMID: 34835964 PMC: 8620690. DOI: 10.3390/nu13113708.

Probiotics in Pediatrics. A Review and Practical Guide.

Depoorter L, Vandenplas Y Nutrients. 2021; 13(7).

PMID: 34202742 PMC: 8308463. DOI: 10.3390/nu13072176.

Prevention and Management with Pro-, Pre and Synbiotics in Children with Asthma and Allergic Rhinitis: A Narrative Review.

Meirlaen L, Levy E, Vandenplas Y Nutrients. 2021; 13(3).

PMID: 33799367 PMC: 7999316. DOI: 10.3390/nu13030934.

Probiotics in Medicine: A Long Debate.

Stavropoulou E, Bezirtzoglou E Front Immunol. 2020; 11:2192.

PMID: 33072084 PMC: 7544950. DOI: 10.3389/fimmu.2020.02192.

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