The Clinical Correlations of Helicobacter Pylori Virulence Factors and Chronic Spontaneous Urticaria

Overview

Journal Gastroenterol Res Pract

Publisher Wiley

Specialty Gastroenterology

Date 2013 Aug 20

PMID 23956739

Citations 5

Authors

Yi-Chun Chiu

Wei-Chen Tai

Seng-Kee Chuah

Ping-I Hsu

Deng-Chyang Wu

Keng-Liang Wu

Chao-Cheng Huang

Ji-Chen Ho

Johannes Ring

Wen-Chieh Chen

Affiliations

Soon will be listed here.

Abstract

Background and Study Aims. The association between Helicobacter pylori (H. pylori) and chronic spontaneous urticaria (CSU) remains controversial. This study explored the role of H. pylori in CSU among different virulent genotypes patients. Patients and Methods. Patients infected by H. pylori were sorted into two groups as group A (with CSU) and group B (without CSU). The tissue materials were taken via endoscopy for polymerase chain reaction study to determine virulence factors. After H. pylori eradication therapy, the eradication rate and response of urticaria were evaluated by using C(13)-UBT and a three-point scale (complete remission, partial remission, or no improvement). Results. The results were comparable between patients of groups A and B in terms of H. pylori infection rates and eradication rate. Longitudinal follow-up of 23.5 months showed complete remission of urticaria in 63.6% but no improvement in 36.4% of the patients after H. pylori eradication. H. pylori infected patients with different virulence factors such as cytotoxin-associated gene A, vacuolating cytotoxin gene A signal region and middle region have similar remission rates for CSU. Conclusions. Current study suggests that H. pylori may play a role in the development and disease course of CSU but may be irrelevant to different virulent genotypes.

Citing Articles

Association between Helicobacter pylori Infection and Chronic Urticaria: A Meta-Analysis.

Gu H, Li L, Gu M, Zhang G Gastroenterol Res Pract. 2015; 2015:486974.

PMID: 25861258 PMC: 4378606. DOI: 10.1155/2015/486974.

Relationship between Helicobacter pylori and idiopathic chronic urticaria: effectiveness of Helicobacter pylori eradication.

Rostami Mogaddam M, Yazdanbod A, Ardabili N, Maleki N, Isazadeh S Postepy Dermatol Alergol. 2015; 32(1):15-20.

PMID: 25821422 PMC: 4360011. DOI: 10.5114/pdia.2015.48729.

Beyond the stomach: an updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment.

Testerman T, Morris J World J Gastroenterol. 2014; 20(36):12781-808.

PMID: 25278678 PMC: 4177463. DOI: 10.3748/wjg.v20.i36.12781.

Extraintestinal manifestations of Helicobacter pylori: a concise review.

Wong F, Rayner-Hartley E, Byrne M World J Gastroenterol. 2014; 20(34):11950-61.

PMID: 25232230 PMC: 4161781. DOI: 10.3748/wjg.v20.i34.11950.

Helicobacter pylori and autoimmune disease: cause or bystander.

Smyk D, Koutsoumpas A, Mytilinaiou M, Rigopoulou E, Sakkas L, Bogdanos D World J Gastroenterol. 2014; 20(3):613-29.

PMID: 24574735 PMC: 3921471. DOI: 10.3748/wjg.v20.i3.613.

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