Transcriptional Delay Stabilizes Bistable Gene Networks

Overview

Journal Phys Rev Lett

Publisher American Physical Society

Specialty Biophysics

Date 2013 Aug 20

PMID 23952450

Citations 19

Authors

Chinmaya Gupta

Jose Manuel Lopez

William Ott

Kresimir Josic

Matthew R Bennett

Affiliations

Soon will be listed here.

Abstract

Transcriptional delay can significantly impact the dynamics of gene networks. Here we examine how such delay affects bistable systems. We investigate several stochastic models of bistable gene networks and find that increasing delay dramatically increases the mean residence times near stable states. To explain this, we introduce a non-Markovian, analytically tractable reduced model. The model shows that stabilization is the consequence of an increased number of failed transitions between stable states. Each of the bistable systems that we simulate behaves in this manner.

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