NGAL and AKI: the End of a Myth?

Overview

Journal Intensive Care Med

Specialty Critical Care

Date 2013 Aug 17

PMID 23949705

Citations 7

Authors

Matthieu Legrand

Michael Darmon

Michael Joannidis

Affiliations

Soon will be listed here.

Citing Articles

The Role of Biomarkers in Diagnosis of Sepsis and Acute Kidney Injury.

Santos Ferreira G, Frota M, Gonzaga M, Vattimo M, Lima C Biomedicines. 2024; 12(5).

PMID: 38790893 PMC: 11118225. DOI: 10.3390/biomedicines12050931.

Subclinical and clinical acute kidney injury share similar urinary peptide signatures and prognosis.

Boutin L, Latosinska A, Mischak H, Deniau B, Asakage A, Legrand M Intensive Care Med. 2023; 49(10):1191-1202.

PMID: 37670154 DOI: 10.1007/s00134-023-07198-2.

Management of acute renal replacement therapy in critically ill cirrhotic patients.

Del Risco-Zevallos J, Molina Andujar A, Pineiro G, Reverter E, Toapanta N, Sanz M Clin Kidney J. 2022; 15(6):1060-1070.

PMID: 35664279 PMC: 9155212. DOI: 10.1093/ckj/sfac025.

Urinary Biomarkers IGFBP7 and TIMP-2 for the Diagnostic Assessment of Transient and Persistent Acute Kidney Injury in Critically Ill Patients.

Daubin D, Cristol J, Dupuy A, Kuster N, Besnard N, Platon L PLoS One. 2017; 12(1):e0169674.

PMID: 28085896 PMC: 5234791. DOI: 10.1371/journal.pone.0169674.

Incidence and risk factors for early renal dysfunction after liver transplantation.

Wiesen P, Massion P, Joris J, Detry O, Damas P World J Transplant. 2016; 6(1):220-32.

PMID: 27011921 PMC: 4801799. DOI: 10.5500/wjt.v6.i1.220.

References

Haase M, Bellomo R, Devarajan P, Schlattmann P, Haase-Fielitz A . Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis. 2009; 54(6):1012-24. DOI: 10.1053/j.ajkd.2009.07.020. View

Eagan T, Damas J, Ueland T, Voll-Aanerud M, Mollnes T, Hardie J . Neutrophil gelatinase-associated lipocalin: a biomarker in COPD. Chest. 2010; 138(4):888-95. DOI: 10.1378/chest.09-2718. View

Krawczeski C, Goldstein S, Woo J, Wang Y, Piyaphanee N, Ma Q . Temporal relationship and predictive value of urinary acute kidney injury biomarkers after pediatric cardiopulmonary bypass. J Am Coll Cardiol. 2011; 58(22):2301-9. PMC: 3220882. DOI: 10.1016/j.jacc.2011.08.017. View

McIlroy D, Wagener G, Lee H . Neutrophil gelatinase-associated lipocalin and acute kidney injury after cardiac surgery: the effect of baseline renal function on diagnostic performance. Clin J Am Soc Nephrol. 2010; 5(2):211-9. PMC: 2827603. DOI: 10.2215/CJN.04240609. View

Legrand M, Collet C, Gayat E, Henao J, Giraudeaux V, Mateo J . Accuracy of urine NGAL commercial assays in critically ill patients. Intensive Care Med. 2012; 39(3):541-2. DOI: 10.1007/s00134-012-2788-5. View

Glassford N, Schneider A, Xu S, Eastwood G, Young H, Peck L . The nature and discriminatory value of urinary neutrophil gelatinase-associated lipocalin in critically ill patients at risk of acute kidney injury. Intensive Care Med. 2013; 39(10):1714-24. DOI: 10.1007/s00134-013-3040-7. View

Mishra J, Ma Q, Kelly C, Mitsnefes M, Mori K, Barasch J . Kidney NGAL is a novel early marker of acute injury following transplantation. Pediatr Nephrol. 2006; 21(6):856-63. DOI: 10.1007/s00467-006-0055-0. View

Maisel A, Mueller C, Fitzgerald R, Brikhan R, Hiestand B, Iqbal N . Prognostic utility of plasma neutrophil gelatinase-associated lipocalin in patients with acute heart failure: the NGAL EvaLuation Along with B-type NaTriuretic Peptide in acutely decompensated heart failure (GALLANT) trial. Eur J Heart Fail. 2011; 13(8):846-51. PMC: 3143832. DOI: 10.1093/eurjhf/hfr087. View

Nickolas T, ORourke M, Yang J, Sise M, Canetta P, Barasch N . Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Intern Med. 2008; 148(11):810-9. PMC: 2909852. DOI: 10.7326/0003-4819-148-11-200806030-00003. View

10.

Cai L, Borowiec J, Xu S, Han W, Venge P . Assays of urine levels of HNL/NGAL in patients undergoing cardiac surgery and the impact of antibody configuration on their clinical performances. Clin Chim Acta. 2009; 403(1-2):121-5. DOI: 10.1016/j.cca.2009.01.030. View

11.

Mishra J, Dent C, Tarabishi R, Mitsnefes M, Ma Q, Kelly C . Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet. 2005; 365(9466):1231-8. DOI: 10.1016/S0140-6736(05)74811-X. View

12.

Martensson J, Bell M, Oldner A, Xu S, Venge P, Martling C . Neutrophil gelatinase-associated lipocalin in adult septic patients with and without acute kidney injury. Intensive Care Med. 2010; 36(8):1333-40. DOI: 10.1007/s00134-010-1887-4. View

13.

de Geus H, Bakker J, Lesaffre E, le Noble J . Neutrophil gelatinase-associated lipocalin at ICU admission predicts for acute kidney injury in adult patients. Am J Respir Crit Care Med. 2010; 183(7):907-14. DOI: 10.1164/rccm.200908-1214OC. View

14.

Schmidt-Ott K, Mori K, Li J, Kalandadze A, Cohen D, Devarajan P . Dual action of neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol. 2007; 18(2):407-13. DOI: 10.1681/ASN.2006080882. View

15.

Kjeldsen L, Johnsen A, Sengelov H, Borregaard N . Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem. 1993; 268(14):10425-32. View

16.

Hjortrup P, Haase N, Wetterslev M, Perner A . Clinical review: Predictive value of neutrophil gelatinase-associated lipocalin for acute kidney injury in intensive care patients. Crit Care. 2013; 17(2):211. PMC: 3672520. DOI: 10.1186/cc11855. View

17.

Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J . Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol. 2003; 14(10):2534-43. DOI: 10.1097/01.asn.0000088027.54400.c6. View

18.

Mehta R, Kellum J, Shah S, Molitoris B, Ronco C, Warnock D . Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007; 11(2):R31. PMC: 2206446. DOI: 10.1186/cc5713. View

19.

Martensson J, Xu S, Bell M, Martling C, Venge P . Immunoassays distinguishing between HNL/NGAL released in urine from kidney epithelial cells and neutrophils. Clin Chim Acta. 2012; 413(19-20):1661-7. DOI: 10.1016/j.cca.2012.05.010. View

20.

Cai L, Rubin J, Han W, Venge P, Xu S . The origin of multiple molecular forms in urine of HNL/NGAL. Clin J Am Soc Nephrol. 2010; 5(12):2229-35. PMC: 2994084. DOI: 10.2215/CJN.00980110. View