The Emerging Role of Cardiovascular Magnetic Resonance in the Evaluation of Kawasaki Disease

Overview

Journal Int J Cardiovasc Imaging

Publisher Springer

Specialty Radiology

Date 2013 Aug 17

PMID 23949280

Citations 12

Authors

Sophie Mavrogeni

George Papadopoulos

Tarique Hussain

Amedeo Chiribiri

Rene Botnar

Gerald F Greil

Affiliations

Soon will be listed here.

Abstract

Kawasaki disease (KD) is a vasculitis affecting the coronary and systemic arteries. Myocardial inflammation is also a common finding in KD post-mortem evaluation during the acute phase of the disease. Coronary artery aneurysms (CAAs) develop in 15-25% of untreated children. Although 50-70% of CAAs resolve spontaneously 1-2 years after the onset of KD, the remaining unresolved CAAs can develop stenotic lesions at either their proximal or distal end and can develop thrombus formation leading to ischemia and/or infarction. Cardiovascular magnetic resonance (CMR) has the ability to perform non-invasive and radiation-free evaluation of the coronary artery lumen. Recently tissue characterization of the coronary vessel wall was provided by CMR. It can also image myocardial inflammation, ischemia and fibrosis. Therefore CMR offers important clinical information during the acute and chronic phase of KD. In the acute phase, it can identify myocardial inflammation, microvascular disease, myocardial infarction, deterioration of left ventricular function, changes of the coronary artery lumen and changes of the coronary artery vessel wall. During the chronic phase, CMR imaging might be of value for risk stratification and to guide treatment.

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References

Naoe S, Takahashi K, Masuda H, Tanaka N . Kawasaki disease. With particular emphasis on arterial lesions. Acta Pathol Jpn. 1991; 41(11):785-97. DOI: 10.1111/j.1440-1827.1991.tb01620.x. View

Kim R, Fieno D, Parrish T, Harris K, Chen E, Simonetti O . Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation. 1999; 100(19):1992-2002. DOI: 10.1161/01.cir.100.19.1992. View

Iles L, Pfluger H, Phrommintikul A, Cherayath J, Aksit P, Gupta S . Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping. J Am Coll Cardiol. 2008; 52(19):1574-80. DOI: 10.1016/j.jacc.2008.06.049. View

Wu Y, Ye Q, Sato K, Foley L, Hitchens T, Ho C . Noninvasive evaluation of cardiac allograft rejection by cellular and functional cardiac magnetic resonance. JACC Cardiovasc Imaging. 2009; 2(6):731-41. PMC: 2752220. DOI: 10.1016/j.jcmg.2009.01.013. View

Gutberlet M, Schwinge K, Freyhardt P, Spors B, Grothoff M, Denecke T . Influence of high magnetic field strengths and parallel acquisition strategies on image quality in cardiac 2D CINE magnetic resonance imaging: comparison of 1.5 T vs. 3.0 T. Eur Radiol. 2005; 15(8):1586-97. DOI: 10.1007/s00330-005-2768-z. View

Mason J, Palac R, Freeman M, Virupannavar S, Loeb H, Kaplan E . Thallium scintigraphy during dobutamine infusion: nonexercise-dependent screening test for coronary disease. Am Heart J. 1984; 107(3):481-5. DOI: 10.1016/0002-8703(84)90089-9. View

Halliburton S, Arbab-Zadeh A, Dey D, Einstein A, Gentry R, George R . State-of-the-art in CT hardware and scan modes for cardiovascular CT. J Cardiovasc Comput Tomogr. 2012; 6(3):154-63. PMC: 3677072. DOI: 10.1016/j.jcct.2012.04.005. View

Cheng A, Pegg T, Karamitsos T, Searle N, Jerosch-Herold M, Choudhury R . Cardiovascular magnetic resonance perfusion imaging at 3-tesla for the detection of coronary artery disease: a comparison with 1.5-tesla. J Am Coll Cardiol. 2007; 49(25):2440-9. DOI: 10.1016/j.jacc.2007.03.028. View

Kondo C, Hiroe M, Nakanishi T, TAKAO A . Detection of coronary artery stenosis in children with Kawasaki disease. Usefulness of pharmacologic stress 201Tl myocardial tomography. Circulation. 1989; 80(3):615-24. DOI: 10.1161/01.cir.80.3.615. View

10.

Bergersen L, Gauvreau K, Marshall A, Kreutzer J, Beekman R, Hirsch R . Procedure-type risk categories for pediatric and congenital cardiac catheterization. Circ Cardiovasc Interv. 2011; 4(2):188-94. DOI: 10.1161/CIRCINTERVENTIONS.110.959262. View

11.

Kato H, Inoue O, Kawasaki T, Fujiwara H, Watanabe T, Toshima H . Adult coronary artery disease probably due to childhood Kawasaki disease. Lancet. 1992; 340(8828):1127-9. DOI: 10.1016/0140-6736(92)93152-d. View

12.

Porcalla A, Sable C, Patel K, Martin G, Singh N . The epidemiology of Kawasaki disease in an urban hospital: does African American race protect against coronary artery aneurysms?. Pediatr Cardiol. 2006; 26(6):775-81. DOI: 10.1007/s00246-005-0916-5. View

13.

Kaandorp T, Lamb H, Poldermans D, Viergever E, Boersma E, van der Wall E . Assessment of right ventricular infarction with contrast-enhanced magnetic resonance imaging. Coron Artery Dis. 2006; 18(1):39-43. DOI: 10.1097/MCA.0b013e32801104c1. View

14.

Larose E, Ganz P, Reynolds H, Dorbala S, Di Carli M, Brown K . Right ventricular dysfunction assessed by cardiovascular magnetic resonance imaging predicts poor prognosis late after myocardial infarction. J Am Coll Cardiol. 2007; 49(8):855-62. DOI: 10.1016/j.jacc.2006.10.056. View

15.

Doesch C, Seeger A, Doering J, Herdeg C, Burgstahler C, Claussen C . Risk stratification by adenosine stress cardiac magnetic resonance in patients with coronary artery stenoses of intermediate angiographic severity. JACC Cardiovasc Imaging. 2009; 2(4):424-33. DOI: 10.1016/j.jcmg.2008.11.017. View

16.

Kim W, Stuber M, Bornert P, Kissinger K, Manning W, Botnar R . Three-dimensional black-blood cardiac magnetic resonance coronary vessel wall imaging detects positive arterial remodeling in patients with nonsignificant coronary artery disease. Circulation. 2002; 106(3):296-9. DOI: 10.1161/01.cir.0000025629.85631.1e. View

17.

Mavrogeni S, Papadopoulos G, Karanasios E, Cokkinos D . "Cardiovascular magnetic resonance imaging reveals myocardial inflammation and coronary artery ectasia during the acute phase of Kawasaki disease". Int J Cardiol. 2008; 136(3):e51-3. DOI: 10.1016/j.ijcard.2008.05.005. View

18.

Wagner A, Mahrholdt H, Holly T, Elliott M, Regenfus M, Parker M . Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet. 2003; 361(9355):374-9. DOI: 10.1016/S0140-6736(03)12389-6. View

19.

Mavrogeni S, Bratis K, Karanasios E, Georgakopoulos D, Kaklis S, Varlamis G . CMR evaluation of cardiac involvement during the convalescence of Kawasaki disease. JACC Cardiovasc Imaging. 2011; 4(10):1140-1. DOI: 10.1016/j.jcmg.2011.04.021. View

20.

Mavrogeni S, Papadopoulos G, Douskou M, Kaklis S, Seimenis I, Varlamis G . Magnetic resonance angiography, function and viability evaluation in patients with Kawasaki disease. J Cardiovasc Magn Reson. 2006; 8(3):493-8. DOI: 10.1080/10976640600604773. View