Pregnancy in a Woman with Homozygous Familial Hypercholesterolemia Not on Low-density Lipoprotein Apheresis

Overview

Journal AJP Rep

Date 2013 Aug 16

PMID 23946902

Citations 2

Authors

Akl C Fahed

Anwar H Nassar

Affiliations

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Abstract

Pregnancy in women with homozygous familial hypercholesterolemia (FH) has been rarely reported and might pose risks on the mother and her fetus. Although most reported cases remained on low-density lipoprotein (LDL) apheresis, there are no clear guidelines regarding the management of this entity. We report the first case of an uncomplicated pregnancy in a 24-year-old homozygous FH woman who was not maintained on LDL apheresis. FH expresses a wide variability in the phenotype, and management of homozygous FH cases who desire to become pregnant should be individualized based on preconceptional assessment with frequent antenatal follow-up. Decisions on management should be made after weighing the risks versus benefits of LDL apheresis.

Citing Articles

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My Approach to the Patient With Familial Hypercholesterolemia.

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