Hot Flashes and Blood Pressure in Middle-aged Japanese Women

Background: Some Western studies have reported that hot flashes are risk factors of cardiovascular diseases. We aimed to investigate the association between hot flashes and blood pressure in middle-aged Japanese women.

Methods: Annual medical checkup data from 1,058 healthy middle-aged Japanese women were analyzed. Nonstandardized coefficients (B), which were calculated by multiple linear regression analysis, were used to evaluate differences in blood pressure resulting from hot flashes.

Results: The prevalence of current hot flashes was 20.2%, and the experience of hot flashes was significantly more frequent according to age (P < 0.01). Systolic blood pressure was significantly higher in women currently experiencing hot flashes and in those experiencing them within the previous month than in those without such experience (B = 6.0, P < 0.01; B = 3.7, P < 0.05, respectively). Diastolic blood pressure was significantly higher in women currently experiencing hot flashes than in those without such experience (B = 3.9; P < 0.01). Among current smokers, systolic blood pressure was 16.4mm Hg higher in those currently experiencing hot flashes (P < 0.01), but this difference was less among nonsmokers (P < 0.05). In addition, pulse pressure was 10.5mm Hg higher in current smokers currently experiencing hot flashes than in other current smokers (P < 0.01), but not among nonsmokers.

Conclusions: In middle-aged Japanese women, hot flashes were associated with higher pulse pressure among smokers but not among nonsmokers.