Protein Adaptation: Mitotic Functions for Membrane Trafficking Proteins

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2013 Aug 15

PMID 23942451

Citations 20

Authors

Stephen J Royle

Affiliations

Soon will be listed here.

Abstract

Membrane trafficking and mitosis are two essential processes in eukaryotic cells. Surprisingly, many proteins best known for their role in membrane trafficking have additional 'moonlighting' functions in mitosis. Despite having proteins in common, there is insufficient evidence for a specific connection between these two processes. Instead, these phenomena demonstrate the adaptability of the membrane trafficking machinery that allows its repurposing for different cellular functions.

Citing Articles

GRP75-driven, cell-cycle-dependent macropinocytosis of Tat/pDNA-Ca nanoparticles underlies distinct gene therapy effect in ovarian cancer.

Su L, Sun Z, Qi F, Su H, Qian L, Li J J Nanobiotechnology. 2022; 20(1):340.

PMID: 35858873 PMC: 9301890. DOI: 10.1186/s12951-022-01530-6.

Class II phosphatidylinositol 3-kinase isoforms in vesicular trafficking.

Yoshioka K Biochem Soc Trans. 2021; 49(2):893-901.

PMID: 33666217 PMC: 8106491. DOI: 10.1042/BST20200835.

Defining endogenous TACC3-chTOG-clathrin-GTSE1 interactions at the mitotic spindle using induced relocalization.

Ryan E, Shelford J, Massam-Wu T, Bayliss R, Royle S J Cell Sci. 2020; 134(3).

PMID: 33380489 PMC: 7875487. DOI: 10.1242/jcs.255794.

A SNARE protein Syntaxin 17 captures CFTR to potentiate autophagosomal clearance under stress.

Arora K, Liyanage P, Zhong Q, Naren A FASEB J. 2020; 35(2):e21185.

PMID: 33191543 PMC: 7855269. DOI: 10.1096/fj.201903210R.

Microtubule-associated proteins (MAPs) in microtubule cytoskeletal dynamics and spermatogenesis.

Wang L, Yan M, Wong C, Ge R, Wu X, Sun F Histol Histopathol. 2020; 36(3):249-265.

PMID: 33174615 DOI: 10.14670/HH-18-279.

References

Foraker A, Camus S, Evans T, Majeed S, Chen C, Taner S . Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG. J Cell Biol. 2012; 198(4):591-605. PMC: 3514040. DOI: 10.1083/jcb.201205116. View

Puhka M, Vihinen H, Joensuu M, Jokitalo E . Endoplasmic reticulum remains continuous and undergoes sheet-to-tubule transformation during cell division in mammalian cells. J Cell Biol. 2007; 179(5):895-909. PMC: 2099207. DOI: 10.1083/jcb.200705112. View

Pucharcos C, Estivill X, de la Luna S . Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis. FEBS Lett. 2000; 478(1-2):43-51. DOI: 10.1016/s0014-5793(00)01793-2. View

Lin C, Hu C, Shih H . Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability. J Cell Biol. 2010; 189(7):1097-105. PMC: 2894451. DOI: 10.1083/jcb.200911120. View

Rosse C, LHoste S, Offner N, Picard A, Camonis J . RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. J Biol Chem. 2003; 278(33):30597-604. DOI: 10.1074/jbc.M302191200. View

Thompson H, Cao H, Chen J, Euteneuer U, McNiven M . Dynamin 2 binds gamma-tubulin and participates in centrosome cohesion. Nat Cell Biol. 2004; 6(4):335-42. DOI: 10.1038/ncb1112. View

Niswonger M, OHalloran T . A novel role for clathrin in cytokinesis. Proc Natl Acad Sci U S A. 1997; 94(16):8575-8. PMC: 23021. DOI: 10.1073/pnas.94.16.8575. View

Scita G, Di Fiore P . The endocytic matrix. Nature. 2010; 463(7280):464-73. DOI: 10.1038/nature08910. View

Zuccolo M, Alves A, Galy V, Bolhy S, Formstecher E, Racine V . The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions. EMBO J. 2007; 26(7):1853-64. PMC: 1847668. DOI: 10.1038/sj.emboj.7601642. View

10.

Pan Q, Shai O, Lee L, Frey B, Blencowe B . Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet. 2008; 40(12):1413-5. DOI: 10.1038/ng.259. View

11.

Royle S, Bright N, Lagnado L . Clathrin is required for the function of the mitotic spindle. Nature. 2005; 434(7037):1152-7. PMC: 3492753. DOI: 10.1038/nature03502. View

12.

BEADLE G, TATUM E . Genetic Control of Biochemical Reactions in Neurospora. Proc Natl Acad Sci U S A. 1941; 27(11):499-506. PMC: 1078370. DOI: 10.1073/pnas.27.11.499. View

13.

Waterman-Storer C, Sanger J, Sanger J . Dynamics of organelles in the mitotic spindles of living cells: membrane and microtubule interactions. Cell Motil Cytoskeleton. 1993; 26(1):19-39. DOI: 10.1002/cm.970260104. View

14.

Goud B, Huet C, Louvard D . Assembled and unassembled pools of clathrin: a quantitative study using an enzyme immunoassay. J Cell Biol. 1985; 100(2):521-7. PMC: 2113452. DOI: 10.1083/jcb.100.2.521. View

15.

Young J, Menetrey J, Goud B . RAB6C is a retrogene that encodes a centrosomal protein involved in cell cycle progression. J Mol Biol. 2010; 397(1):69-88. DOI: 10.1016/j.jmb.2010.01.009. View

16.

Quaroni A, Paul E . Cytocentrin is a Ral-binding protein involved in the assembly and function of the mitotic apparatus. J Cell Sci. 1999; 112 ( Pt 5):707-18. DOI: 10.1242/jcs.112.5.707. View

17.

Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M . Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. EMBO J. 2004; 23(6):1267-78. PMC: 381410. DOI: 10.1038/sj.emboj.7600135. View

18.

Lee D, Zhao X, Yim Y, Eisenberg E, Greene L . Essential role of cyclin-G-associated kinase (Auxilin-2) in developing and mature mice. Mol Biol Cell. 2008; 19(7):2766-76. PMC: 2441687. DOI: 10.1091/mbc.e07-11-1115. View

19.

Tooze J, Hollinshead M . Evidence that globular Golgi clusters in mitotic HeLa cells are clustered tubular endosomes. Eur J Cell Biol. 1992; 58(2):228-42. View

20.

Fu W, Tao W, Zheng P, Fu J, Bian M, Jiang Q . Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment. J Cell Sci. 2010; 123(Pt 21):3645-51. DOI: 10.1242/jcs.075911. View