Different Genetic Associations of the IgE Production Among Fetus, Infancy and Childhood

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Aug 13

PMID 23936416

Citations 9

Authors

Jen-Chieh Chang

Ho-Chang Kuo

Te-Yao Hsu

Chia-Yu Ou

Chieh-An Liu

Hau Chuang

Hsiu-Mei Liang

Hurng-Wern Huang

Kuender D Yang

Affiliations

Soon will be listed here.

Abstract

Elevation of serum IgE levels has long been associated with allergic diseases. Many genes have been linked to IgE production, but few have been linked to the developmental aspects of genetic association with IgE production. To clarify developmental genetic association, we investigated what genes and gene-gene interactions affect IgE levels among fetus, infancy and childhood in Taiwan individuals. A birth cohort of 571 children with completion of IgE measurements from newborn to 1.5, 3, and 6 years of age was subject to genetic association analysis on the 384-customized SNPs of 159 allergy candidate genes. Fifty-three SNPs in 37 genes on innate and adaptive immunity, and stress and response were associated with IgE production. Polymorphisms of the IL13, and the HLA-DPA1 and HLA-DQA1 were, respectively, the most significantly associated with the IgE production at newborn and 6 years of age. Analyses of gene-gene interactions indentified that the combination of NPSR1, rs324981 TT with FGF1, rs2282797 CC had the highest risk (85.7%) of IgE elevation at 1.5 years of age (P=1.46 × 10(-4)). The combination of IL13, CYFIP2 and PDE2A was significantly associated with IgE elevation at 3 years of age (P=5.98 × 10(-7)), and the combination of CLEC2D, COLEC11 and CCL2 was significantly associated with IgE elevation at 6 years of age (P=6.65 × 10(-7)). Our study showed that the genetic association profiles of the IgE production among fetus, infancy and childhood are different. Genetic markers for early prediction and prevention of allergic sensitization may rely on age-based genetic association profiles.

Citing Articles

A Positive Causal Effect of Shrimp Allergy on Major Depressive Disorder Mediated by Allergy- and Immune-Related Pathways in the East Asian Population.

Rao S, Chen X, Ou O, Chair S, Chien W, Liu G Nutrients. 2024; 16(1).

PMID: 38201909 PMC: 10780813. DOI: 10.3390/nu16010079.

Proposal for a 6-step approach for differential diagnosis of neonatal erythroderma.

Cuperus E, Bygum A, Boeckmann L, Bodemer C, Bolling M, Caproni M J Eur Acad Dermatol Venereol. 2022; 36(7):973-986.

PMID: 35238435 PMC: 9310754. DOI: 10.1111/jdv.18043.

T2-high Asthma, Classified by Sputum mRNA Expression of , , and , is Characterized by Eosinophilia and Severe Phenotype.

Rijavec M, Krumpestar T, Skrgat S, Kern I, Korosec P Life (Basel). 2021; 11(2).

PMID: 33513844 PMC: 7911289. DOI: 10.3390/life11020092.

Maternal atopy and offspring epigenome-wide methylation signature.

Danielewicz H, Gurgul A, Debinska A, Myszczyszyn G, Szmatola T, Myszkal A Epigenetics. 2020; 16(6):629-641.

PMID: 32902349 PMC: 8143219. DOI: 10.1080/15592294.2020.1814504.

Maturation of Gut Microbiota and Circulating Regulatory T Cells and Development of IgE Sensitization in Early Life.

Ruohtula T, de Goffau M, Nieminen J, Honkanen J, Siljander H, Hamalainen A Front Immunol. 2019; 10:2494.

PMID: 31749800 PMC: 6842923. DOI: 10.3389/fimmu.2019.02494.

References

Karmaus W, Arshad H, Mattes J . Does the sibling effect have its origin in utero? Investigating birth order, cord blood immunoglobulin E concentration, and allergic sensitization at age 4 years. Am J Epidemiol. 2001; 154(10):909-15. DOI: 10.1093/aje/154.10.909. View

Fryer A, Bianco A, Hepple M, Jones P, Strange R, Spiteri M . Polymorphism at the glutathione S-transferase GSTP1 locus. A new marker for bronchial hyperresponsiveness and asthma. Am J Respir Crit Care Med. 2000; 161(5):1437-42. DOI: 10.1164/ajrccm.161.5.9903006. View

Van Asperen P, Kemp A, Mellis C . Skin test reactivity and clinical allergen sensitivity in infancy. J Allergy Clin Immunol. 1984; 73(3):381-6. DOI: 10.1016/0091-6749(84)90412-3. View

Woszczek G, Kowalski M, Borowiec M . Association of asthma and total IgE levels with human leucocyte antigen-DR in patients with grass allergy. Eur Respir J. 2002; 20(1):79-85. DOI: 10.1183/09031936.02.01002001. View

Moffatt M, Schou C, Faux J, Abecasis G, James A, Musk A . Association between quantitative traits underlying asthma and the HLA-DRB1 locus in a family-based population sample. Eur J Hum Genet. 2001; 9(5):341-6. DOI: 10.1038/sj.ejhg.5200636. View

Granada M, Wilk J, Tuzova M, Strachan D, Weidinger S, Albrecht E . A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. J Allergy Clin Immunol. 2011; 129(3):840-845.e21. PMC: 3293994. DOI: 10.1016/j.jaci.2011.09.029. View

Zhu Z, Homer R, Wang Z, Chen Q, Geba G, Wang J . Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest. 1999; 103(6):779-88. PMC: 408149. DOI: 10.1172/JCI5909. View

Li X, Howard T, Zheng S, Haselkorn T, Peters S, Meyers D . Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. J Allergy Clin Immunol. 2010; 125(2):328-335.e11. PMC: 2824608. DOI: 10.1016/j.jaci.2009.11.018. View

Kere J . Mapping and identifying genes for asthma and psoriasis. Philos Trans R Soc Lond B Biol Sci. 2005; 360(1460):1551-61. PMC: 1569524. DOI: 10.1098/rstb.2005.1684. View

10.

Ciprandi G, De Amici M, Marseglia G . Comparison of serum specific IgE and skin prick test in polysensitized children. Clin Lab. 2011; 57(1-2):83-5. View

11.

Vercelli D . Advances in asthma and allergy genetics in 2007. J Allergy Clin Immunol. 2008; 122(2):267-71. DOI: 10.1016/j.jaci.2008.06.008. View

12.

Moffatt M, Faux J, Lester S, Pare P, McCluskey J, Spargo R . Atopy, respiratory function and HLA-DR in Aboriginal Australians. Hum Mol Genet. 2003; 12(6):625-30. View

13.

Chen C, Weidinger S, Klopp N, Sausenthaler S, BISCHOF W, Herbarth O . Common variants in FCER1A influence total serum IgE levels from cord blood up to six years of life. Allergy. 2009; 64(9):1327-32. DOI: 10.1111/j.1398-9995.2009.02005.x. View

14.

Ferguson A, Dimich-Ward H, Becker A, Watson W, Dybuncio A, Carlsten C . Elevated cord blood IgE is associated with recurrent wheeze and atopy at 7 yrs in a high risk cohort. Pediatr Allergy Immunol. 2009; 20(8):710-3. DOI: 10.1111/j.1399-3038.2009.00869.x. View

15.

Ritchie M, Hahn L, Roodi N, BAILEY L, Dupont W, Parl F . Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am J Hum Genet. 2001; 69(1):138-47. PMC: 1226028. DOI: 10.1086/321276. View

16.

Sadeghnejad A, Karmaus W, Arshad S, Ewart S . IL13 gene polymorphism association with cord serum immunoglobulin E. Pediatr Allergy Immunol. 2007; 18(4):288-92. PMC: 2366045. DOI: 10.1111/j.1399-3038.2006.00524.x. View

17.

Shiina T, Inoko H, Kulski J . An update of the HLA genomic region, locus information and disease associations: 2004. Tissue Antigens. 2004; 64(6):631-49. DOI: 10.1111/j.1399-0039.2004.00327.x. View

18.

Heinrich J, Bolte G, HOLSCHER B, Douwes J, Lehmann I, Fahlbusch B . Allergens and endotoxin on mothers' mattresses and total immunoglobulin E in cord blood of neonates. Eur Respir J. 2002; 20(3):617-23. DOI: 10.1183/09031936.02.02322001. View

19.

Yang K, Chang J, Chuang H, Liang H, Kuo H, Lee Y . Gene-gene and gene-environment interactions on IgE production in prenatal stage. Allergy. 2009; 65(6):731-9. DOI: 10.1111/j.1398-9995.2009.02260.x. View

20.

Malerba G, Pignatti P . A review of asthma genetics: gene expression studies and recent candidates. J Appl Genet. 2005; 46(1):93-104. View