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Bilateral Optic Disc Oedema and Associated Optic Neuropathy in the Setting of FOLFOX Chemotherapy

Overview
Journal BMC Ophthalmol
Publisher Biomed Central
Specialty Ophthalmology
Date 2013 Aug 10
PMID 23926927
Citations 5
Authors
Liam D Turner
John D Harrison
Affiliations
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Abstract

Background: To report a case of bilateral optic disc oedema and associated optic neuropathy in the setting of FOLFOX chemotherapy.

Case Presentation: A case of a 57-year-old male being treated with FOLFOX chemotherapy for stage 3B colorectal cancer, who developed bilateral optic disc oedema and associated left sided optic neuropathy is described. The patient presented following cycles 7, 8 and 9 of chemotherapy with a history of bilateral simultaneous intermittent inferior altitudinal field defects. These episodes progressed to bilateral optic nerve oedema and a subsequent left sided optic neuropathy. The patient's symptoms and oedema regressed with discontinuation of chemotherapy.

Conclusion: This is the first report suggesting a vasospastic role of 5-fluoruracil in 5-FU associated optic neuropathy. It highlights that 5-FU may have the potential to cause arterial vasospasm outside the cardiac vasculature, resulting in end-organ optic nerve ischaemia.

Citing Articles

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Anterior ischemic optic neuropathy in a patient with optic disc Drusen while on FOLFOX Chemotherapy for colon cancer: the value of Occam's Razor and Hickam's dictum.

Elnahry A Rom J Ophthalmol. 2019; 63(2):174-177.

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Kunkler A, Binkley E, Mantopoulos D, Hendershot A, Ohr M, Kendra K Graefes Arch Clin Exp Ophthalmol. 2019; 257(8):1771-1781.

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