Chromosomal Abnormalities in Infertile Men Referred to Iran Blood Transfusion Organization Research Center

Overview

Journal J Reprod Infertil

Specialty Reproductive Medicine

Date 2013 Aug 9

PMID 23926486

Citations 3

Authors

Mahjoubi Frouzandeh

Soleimani Saeideh

Mantegy Sanaz

Affiliations

Soon will be listed here.

Abstract

Introduction: The prevalence of somatic chromosomal abnormalities in infertile male individuals has been reported to vary in different literatures. The aim of this study was to investigate the frequency of chromosomal aberrations among infertile men referred to the Cytogenetic Laboratory of Iran Blood Transfusion Organization Research Centre (IBTO).

Materials And Methods: Chromosomal analysis was performed on phytohemag-glutinin (PHA)-stimulated peripheral lymphocyte cultures of 1052 infertile men using standard cytogenetic methods. The study took place during 1997 to 2007.

Results: Total chromosome alterations were revealed in 161 (15.30%) infertile men. The most prevalent chromosomal abnormality in the infertile men was 47, XXY, that was seen in 94 (58.38%) men while one of them had a mosaic karyotype: mos 47, XX[54]/47,XXY[18]/46,XY[9]. In 37 (22.98%) cases, structural aberrations were detected. There were 30 (18.63%) cases of sex reversal.

Conclusion: Cytogenetic studies of these patients showed increased chromosomal abnormalities in infertile men in comparison with that of the normal population, justifying the need for cytogenetic analysis of men with idiopathic infertility.

Citing Articles

Basic and clinical genetic studies on male infertility in Iran during 2000-2016: A review.

Moghbelinejad S, Mozdarani H, Ghoraeian P, Asadi R Int J Reprod Biomed. 2018; 16(3):131-148.

PMID: 29766145 PMC: 5944436.

Cytogenetic Abnormalities Found in Patients with Reproductive Problems.

Mackic-Djurovic M, Hasic S, Kiseljakovic E, Rukavina D, Ibrulj S Med Arch. 2018; 71(6):396-399.

PMID: 29416198 PMC: 5764602. DOI: 10.5455/medarh.2017.71.396-399.

Chromosomal aberrations and polymorphic evaluation in males with primary infertility from Indian population.

Kate U, Pokale Y, Jadhav A, Gangane S J Clin Diagn Res. 2014; 8(10):SC01-6.

PMID: 25478430 PMC: 4253248. DOI: 10.7860/JCDR/2014/8644.4933.

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