Passive Movement Improves the Learning and Memory Function of Rats with Cerebral Infarction by Inhibiting Neuron Cell Apoptosis

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2013 Aug 9

PMID 23925702

Citations 6

Authors

Man Li

Jun Peng

Meng-Die Wang

Yan-Ling Song

Yuan-Wu Mei

Yuan Fang

Affiliations

Soon will be listed here.

Abstract

Passive movement has been found to improve evidently ischemic stroke patients' impaired capacity of learning and memory, but the optimal time window of initiating the therapy and the underlying mechanism are not fully understood. In this study, the effect of passive movement at different time windows on learning and memory of rats with cerebral infarction was detected. The results showed that the expression of caspase-3 and escape latency in the passive movement group were all considerably lower than those in the model group (P < 0.05), while the expression of Bcl-2 mRNA was significantly higher than those in the model group (P < 0.05). Moreover, we found that there were most significant changes of escape latency and expressions of Bcl-2 mRNA and caspase-3 when the therapy started at 24 h after focal cerebral infarction. These results suggest that passive movement is able to contribute to the recovery of learning and memory of rats with cerebral infarction, which is partially mediated by inhibiting neuron cell apoptosis, and the optimal therapeutic time is at 24 h after cerebral infarction.

Citing Articles

Desflurane improves electrical activity of neurons and alleviates oxygen-glucose deprivation-induced neuronal injury by activating the Kcna1-dependent Kv1.1 channel.

Ni X, Yu X, Ye Q, Su X, Shen S Exp Brain Res. 2024; 242(2):477-490.

PMID: 38184806 DOI: 10.1007/s00221-023-06764-w.

Transcranial direct current stimulation alleviated ischemic stroke induced injury involving the BDNF-TrkB signaling axis in rats.

Zhou Q, Chen Y, Tang H, Zhang L, Ma Y, Bai D Heliyon. 2023; 9(4):e14946.

PMID: 37089354 PMC: 10114158. DOI: 10.1016/j.heliyon.2023.e14946.

7,8-Dihydroxyflavone protects neurons against oxygen-glucose deprivation induced apoptosis and activates the TrkB/Akt pathway.

Zhou Q, Tang H, Bai D, Kong Y PeerJ. 2022; 10:e12886.

PMID: 35186478 PMC: 8855723. DOI: 10.7717/peerj.12886.

Xanomeline Protects Cortical Cells From Oxygen-Glucose Deprivation via Inhibiting Oxidative Stress and Apoptosis.

Xin R, Chen Z, Fu J, Shen F, Zhu Q, Huang F Front Physiol. 2020; 11:656.

PMID: 32595528 PMC: 7303960. DOI: 10.3389/fphys.2020.00656.

The Effectiveness of Early Mobilization Time on Balance and Functional Ability after Ischemic Stroke.

Rahayu U, Wibowo S, Setyopranoto I Open Access Maced J Med Sci. 2019; 7(7):1088-1092.

PMID: 31049086 PMC: 6490474. DOI: 10.3889/oamjms.2019.269.

References

Tatemichi T, Desmond D, Mayeux R, Paik M, Stern Y, Sano M . Dementia after stroke: baseline frequency, risks, and clinical features in a hospitalized cohort. Neurology. 1992; 42(6):1185-93. DOI: 10.1212/wnl.42.6.1185. View

Li M, Peng J, Song Y, Liang H, Mei Y, Fang Y . Electro-acupuncture combined with transcranial magnetic stimulation improves learning and memory function of rats with cerebral infarction by inhibiting neuron cell apoptosis. J Huazhong Univ Sci Technolog Med Sci. 2012; 32(5):746-749. DOI: 10.1007/s11596-012-1028-0. View

Ang E, Dawe G, Wong P, Moochhala S, Ng Y . Alterations in spatial learning and memory after forced exercise. Brain Res. 2006; 1113(1):186-93. DOI: 10.1016/j.brainres.2006.07.023. View

Longa E, Weinstein P, Carlson S, Cummins R . Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989; 20(1):84-91. DOI: 10.1161/01.str.20.1.84. View

Luo C, Jiang J, Zhou Q, Zhu X, Wang W, Zhang Z . Voluntary exercise-induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke. J Neurosci Res. 2007; 85(8):1637-46. DOI: 10.1002/jnr.21317. View

Houle J, Morris K, Skinner R, Garcia-Rill E, Peterson C . Effects of fetal spinal cord tissue transplants and cycling exercise on the soleus muscle in spinalized rats. Muscle Nerve. 1999; 22(7):846-56. DOI: 10.1002/(sici)1097-4598(199907)22:7<846::aid-mus6>3.0.co;2-i. View

van Praag H, Christie B, Sejnowski T, Gage F . Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci U S A. 1999; 96(23):13427-31. PMC: 23964. DOI: 10.1073/pnas.96.23.13427. View

Lloyd-Jones D, Adams R, Carnethon M, de Simone G, Ferguson T, Flegal K . Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009; 119(3):480-6. DOI: 10.1161/CIRCULATIONAHA.108.191259. View

Dromerick A, Lang C, Birkenmeier R, Wagner J, Miller J, Videen T . Very Early Constraint-Induced Movement during Stroke Rehabilitation (VECTORS): A single-center RCT. Neurology. 2009; 73(3):195-201. PMC: 2715572. DOI: 10.1212/WNL.0b013e3181ab2b27. View

10.

SWANTON E, Savory P, Cosulich S, Clarke P, Woodman P . Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts. Oncogene. 1999; 18(10):1781-7. DOI: 10.1038/sj.onc.1202490. View

11.

Ma Y, He M, Qiang L . Exercise Therapy Downregulates the Overexpression of TLR4, TLR2, MyD88 and NF-κB after Cerebral Ischemia in Rats. Int J Mol Sci. 2013; 14(2):3718-33. PMC: 3588067. DOI: 10.3390/ijms14023718. View

12.

Radak Z, Toldy A, Szabo Z, Siamilis S, Nyakas C, Silye G . The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain. Neurochem Int. 2006; 49(4):387-92. DOI: 10.1016/j.neuint.2006.02.004. View

13.

Zhao S, Zhao M, Xiao T, Jolkkonen J, Zhao C . Constraint-induced movement therapy overcomes the intrinsic axonal growth-inhibitory signals in stroke rats. Stroke. 2013; 44(6):1698-705. DOI: 10.1161/STROKEAHA.111.000361. View

14.

Zhang P, Yu H, Zhou N, Zhang J, Wu Y, Zhang Y . Early exercise improves cerebral blood flow through increased angiogenesis in experimental stroke rat model. J Neuroeng Rehabil. 2013; 10:43. PMC: 3648391. DOI: 10.1186/1743-0003-10-43. View

15.

Lou S, Liu J, Chang H, Chen P . Hippocampal neurogenesis and gene expression depend on exercise intensity in juvenile rats. Brain Res. 2008; 1210:48-55. DOI: 10.1016/j.brainres.2008.02.080. View

16.

Zhang R, Xue Y, Lu S, Wang Y, Zhang L, Huang Y . Bcl-2 enhances neurogenesis and inhibits apoptosis of newborn neurons in adult rat brain following a transient middle cerebral artery occlusion. Neurobiol Dis. 2006; 24(2):345-56. DOI: 10.1016/j.nbd.2006.07.012. View

17.

Okada M, Tamura A, Urae A, Nakagomi T, Kirino T, Mine K . Long-term spatial cognitive impairment following middle cerebral artery occlusion in rats. A behavioral study. J Cereb Blood Flow Metab. 1995; 15(3):505-12. DOI: 10.1038/jcbfm.1995.62. View

18.

Saxena S, Ng T, Koh G, Yong D, Fong N . Is improvement in impaired cognition and depressive symptoms in post-stroke patients associated with recovery in activities of daily living?. Acta Neurol Scand. 2007; 115(5):339-46. DOI: 10.1111/j.1600-0404.2006.00751.x. View

19.

Morris R . Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods. 1984; 11(1):47-60. DOI: 10.1016/0165-0270(84)90007-4. View

20.

Ni B, Wu X, Su Y, Stephenson D, Smalstig E, Clemens J . Transient global forebrain ischemia induces a prolonged expression of the caspase-3 mRNA in rat hippocampal CA1 pyramidal neurons. J Cereb Blood Flow Metab. 1998; 18(3):248-56. DOI: 10.1097/00004647-199803000-00003. View