Aberrant Default Mode Functional Connectivity in Early Onset Schizophrenia

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Aug 8

PMID 23923052

Citations 34

Authors

Jinsong Tang

Yanhui Liao

Ming Song

Jia-Hong Gao

Bing Zhou

Changlian Tan

Tieqiao Liu

Yanqing Tang

Jindong Chen

Xiaogang Chen

Affiliations

Soon will be listed here.

Abstract

Background: The default mode network (DMN) has been linked to a number of mental disorders including schizophrenia. However, the abnormal connectivity of DMN in early onset schizophrenia (EOS) has been rarely reported.

Methods: Independent component analysis (ICA) was used to investigate functional connectivity (FC) of the DMN in 32 first-episode adolescents with EOS and 32 age and gender-matched healthy controls.

Results: Compared to healthy controls, patients with EOS showed increased FC between the medial frontal gyrus and other areas of the DMN. Partial correlation analyses showed that the FC of medial frontal gyrus significantly correlated with PANSS-positive symptoms (partial correlation coefficient = 0.538, Bonferoni corrected P = 0.018).

Limitations: Although the sample size of participants was comparable with most fMRI studies to date, it was still relatively small. Pediatric brains were registered to the MNI adult brain template. However, possible age-specific differences in spatial normalization that arise from registering pediatric brains to the MNI adult brain template may have little effect on fMRI results.

Conclusion: This study provides evidence for functional abnormalities of DMN in first-episode EOS. These abnormalities could be a source of abnormal introspectively-oriented mental actives.

Citing Articles

Controllability of Functional Brain Networks and Its Clinical Significance in First-Episode Schizophrenia.

Li Q, Yao L, You W, Liu J, Deng S, Li B Schizophr Bull. 2022; 49(3):659-668.

PMID: 36402458 PMC: 10154712. DOI: 10.1093/schbul/sbac177.

Large-scale networks underlie cognitive insight differs between untreated adolescents ongoing their first schizophrenic episode and their reference non-schizophrenic mates.

Ji R, Zhou M, Ou N, Chen H, Li Y, Zhuo L Heliyon. 2022; 8(10):e10818.

PMID: 36217472 PMC: 9547213. DOI: 10.1016/j.heliyon.2022.e10818.

Evaluation of functional MRI-based human brain parcellation: a review.

Moghimi P, Dang A, Do Q, Netoff T, Lim K, Atluri G J Neurophysiol. 2022; 128(1):197-217.

PMID: 35675446 PMC: 9291407. DOI: 10.1152/jn.00411.2021.

Aberrant default mode connectivity in adolescents with early-onset psychosis: A resting state fMRI study.

Hilland E, Johannessen C, Jonassen R, Alnaes D, Jorgensen K, Barth C Neuroimage Clin. 2021; 33:102881.

PMID: 34883402 PMC: 8662331. DOI: 10.1016/j.nicl.2021.102881.

Individual-specific functional connectome biomarkers predict schizophrenia positive symptoms during adolescent brain maturation.

Fan Y, Li L, Peng Y, Li H, Guo J, Li M Hum Brain Mapp. 2020; .

PMID: 33289223 PMC: 7927287. DOI: 10.1002/hbm.25307.

References

Frith C . Functional imaging and cognitive abnormalities. Lancet. 1995; 346(8975):615-20. DOI: 10.1016/s0140-6736(95)91441-2. View

Fransson P . Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis. Hum Brain Mapp. 2005; 26(1):15-29. PMC: 6871700. DOI: 10.1002/hbm.20113. View

Bell A, Sejnowski T . An information-maximization approach to blind separation and blind deconvolution. Neural Comput. 1995; 7(6):1129-59. DOI: 10.1162/neco.1995.7.6.1129. View

Garrity A, Pearlson G, McKiernan K, Lloyd D, Kiehl K, Calhoun V . Aberrant "default mode" functional connectivity in schizophrenia. Am J Psychiatry. 2007; 164(3):450-7. DOI: 10.1176/ajp.2007.164.3.450. View

Schultz S, Andreasen N . Schizophrenia. Lancet. 1999; 353(9162):1425-30. DOI: 10.1016/s0140-6736(98)07549-7. View

Alexander-Bloch A, Lambiotte R, Roberts B, Giedd J, Gogtay N, Bullmore E . The discovery of population differences in network community structure: new methods and applications to brain functional networks in schizophrenia. Neuroimage. 2011; 59(4):3889-900. PMC: 3478383. DOI: 10.1016/j.neuroimage.2011.11.035. View

Friston K, Holmes A, Poline J, Grasby P, Williams S, Frackowiak R . Analysis of fMRI time-series revisited. Neuroimage. 1995; 2(1):45-53. DOI: 10.1006/nimg.1995.1007. View

Freire L, Roche A, Mangin J . What is the best similarity measure for motion correction in fMRI time series?. IEEE Trans Med Imaging. 2002; 21(5):470-84. DOI: 10.1109/TMI.2002.1009383. View

Woodward N, Rogers B, Heckers S . Functional resting-state networks are differentially affected in schizophrenia. Schizophr Res. 2011; 130(1-3):86-93. PMC: 3139756. DOI: 10.1016/j.schres.2011.03.010. View

10.

Jafri M, Pearlson G, Stevens M, Calhoun V . A method for functional network connectivity among spatially independent resting-state components in schizophrenia. Neuroimage. 2007; 39(4):1666-81. PMC: 3164840. DOI: 10.1016/j.neuroimage.2007.11.001. View

11.

Gusnard D, Akbudak E, Shulman G, Raichle M . Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc Natl Acad Sci U S A. 2001; 98(7):4259-64. PMC: 31213. DOI: 10.1073/pnas.071043098. View

12.

Mason M, Norton M, Van Horn J, Wegner D, Grafton S, Neil Macrae C . Wandering minds: the default network and stimulus-independent thought. Science. 2007; 315(5810):393-5. PMC: 1821121. DOI: 10.1126/science.1131295. View

13.

Li Y, Adali T, Calhoun V . Estimating the number of independent components for functional magnetic resonance imaging data. Hum Brain Mapp. 2007; 28(11):1251-66. PMC: 6871474. DOI: 10.1002/hbm.20359. View

14.

Raichle M, Snyder A . A default mode of brain function: a brief history of an evolving idea. Neuroimage. 2007; 37(4):1083-90. DOI: 10.1016/j.neuroimage.2007.02.041. View

15.

Karbasforoushan H, Woodward N . Resting-state networks in schizophrenia. Curr Top Med Chem. 2013; 12(21):2404-14. DOI: 10.2174/156802612805289863. View

16.

Bluhm R, Miller J, Lanius R, Osuch E, Boksman K, Neufeld R . Spontaneous low-frequency fluctuations in the BOLD signal in schizophrenic patients: anomalies in the default network. Schizophr Bull. 2007; 33(4):1004-12. PMC: 2632312. DOI: 10.1093/schbul/sbm052. View

17.

Frith U, Frith C . Development and neurophysiology of mentalizing. Philos Trans R Soc Lond B Biol Sci. 2003; 358(1431):459-73. PMC: 1693139. DOI: 10.1098/rstb.2002.1218. View

18.

Rapoport J, Addington A, Frangou S, Psych M . The neurodevelopmental model of schizophrenia: update 2005. Mol Psychiatry. 2005; 10(5):434-49. DOI: 10.1038/sj.mp.4001642. View

19.

Kang H, Burgund E, Lugar H, Petersen S, Schlaggar B . Comparison of functional activation foci in children and adults using a common stereotactic space. Neuroimage. 2003; 19(1):16-28. DOI: 10.1016/s1053-8119(03)00038-7. View

20.

Ongur D, Lundy M, Greenhouse I, Shinn A, Menon V, Cohen B . Default mode network abnormalities in bipolar disorder and schizophrenia. Psychiatry Res. 2010; 183(1):59-68. PMC: 2902695. DOI: 10.1016/j.pscychresns.2010.04.008. View