Interleukin 10 (IL10) and Transforming Growth Factor β1 (TGFβ1) Gene Polymorphisms in Persistent IgE-mediated Cow's Milk Allergy

Overview

Journal Clinics (Sao Paulo)

Publisher Elsevier

Specialty General Medicine

Date 2013 Aug 7

PMID 23917667

Citations 9

Authors

Cristina Miuki Abe Jacob

Antonio Carlos Pastorino

Thelma Suely Okay

Ana Paula B M Castro

Andrea Keiko F Gushken

Leticia Aki Watanabe

Vanessa C Z Frucchi

Lea Campos de Oliveira

Affiliations

Soon will be listed here.

Abstract

Objectives: The aim of this cross-sectional study was to evaluate whether interleukin 10 (IL10) and transforming growth factor β1 (TGFβ1) gene polymorphisms were associated with persistent IgE-mediated cow's milk allergy in 50 Brazilian children. The diagnostic criteria were anaphylaxis triggered by cow's milk or a positive double-blind, placebo-controlled food challenge. Tolerance was defined as the absence of a clinical response to a double-blind, placebo-controlled food challenge or cow's milk exposure.

Method: The genomic DNA of the 50 patients and 224 healthy controls (HCs) was used to investigate five IL10 gene polymorphisms (-3575A/T, -2849A/G, -2763A/C, -1082G/A, -592C/A) and one TGFβ1 polymorphism (-509C/T).

Results: Among the five IL10 polymorphisms analyzed, homozygosis for the G allele at the -1082 position was significantly higher in the patients compared with the healthy controls (p=0.027) and in the persistent cow's milk allergy group compared with the healthy controls (p=0.001).

Conclusions: Homozygosis for the G allele at the IL10 -1082G/A polymorphism is associated with the persistent form of cow's milk allergy.

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