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Psychopathological Traits of Adolescents with Functional Hypothalamic Amenorrhea: a Comparison with Anorexia Nervosa

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Publisher Springer
Date 2013 Aug 6
PMID 23912931
Citations 8
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Abstract

Background: Functional hypothalamic amenorrhea (FHA) is a form of anovulation, due to the suppression of hypothalamic-pituitary-ovarian axis, not related to identifiable organic causes. Like adolescents with anorexia nervosa (AN), subjects with FHA show dysfunctional attitudes, low self-esteem, depressive mood, anxiety and inability to cope with daily stress. The aim of the study is to examine similarities and differences between FHA and AN in terms of clinical profiles and psychological variables.

Methods: 21 adolescents with FHA, 21 adolescents with anorexia nervosa, and 21 healthy adolescents were included in the study. All the teenagers completed a battery of self-administered psychological tests for the detection of behaviors and symptoms attributable to the presence of an eating disorder (EDI-2), depression (CDI), and alexithymia (TAS-20).

Results: Different from healthy controls, subjects with FHA and with AN shared common psychopathological aspects, such as maturity issues, social insecurity and introversion, a tendency to depression, excessive concerns with dieting, and fear of gaining weight. Nevertheless, adolescents with AN presented a more profound psychopathological disorder as observed at test comparisons with subjects with FHA.

Conclusions: Results show a clinical spectrum that includes AN and FHA and suggest the necessity to treat FHA with a multidisciplinary approach for both organic and psychological aspects.

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References
1.
REIFENSTEIN Jr E . Psychogenic or hypothalamic amenorrhea. Med Clin North Am. 2010; 30:1103-14. DOI: 10.1016/s0025-7125(16)35908-9. View

2.
Moles A, Rizzi R, DAmato F . Postnatal stress in mice: does "stressing" the mother have the same effect as "stressing" the pups?. Dev Psychobiol. 2004; 44(4):230-7. DOI: 10.1002/dev.20008. View

3.
Nappi R, Facchinetti F . Psychoneuroendocrine correlates of secondary amenorrhea. Arch Womens Ment Health. 2003; 6(2):83-9. DOI: 10.1007/s00737-002-0152-4. View

4.
Bagby R, Taylor G, Parker J . The Twenty-item Toronto Alexithymia Scale--II. Convergent, discriminant, and concurrent validity. J Psychosom Res. 1994; 38(1):33-40. DOI: 10.1016/0022-3999(94)90006-x. View

5.
Munoz M, Argente J . Anorexia nervosa in female adolescents: endocrine and bone mineral density disturbances. Eur J Endocrinol. 2002; 147(3):275-86. DOI: 10.1530/eje.0.1470275. View