Ace I/D Polymorphism is Associated with Habitual Physical Activity in Pubertal Boys

Overview

Journal J Physiol Sci

Specialty Physiology

Date 2013 Aug 6

PMID 23912524

Citations 4

Authors

Jarek Maestu

Evelin Latt

Triin Raask

Katrin Sak

Kariina Laas

Jaak Jurimae

Toivo Jurimae

Affiliations

Soon will be listed here.

Abstract

We investigated the association between the angiotensin I-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphism and physical activity levels in boys at early pubertal stage (calendar age 12.04 ± 0.77 years). Body composition by DXA, pubertal stage and cardiovascular fitness on cycle ergometer were measured in addition to 7-day accelerometry. DNA was separated from the whole blood. Sedentary behaviour level was significantly lower in DD subjects compared to I allele carriers. A significant main effect of the D allele was found on total physical activity (F 1,256 = 5,453; p = 0.020; η (2) = 0.021] and on light physical activity (F 1,256 = 4.74; p = 0.030; η (2) = 0.018). Adding screen time as a covariate did not change ACE I/D polymorphism effect on total physical activity levels (F 2,256 = 3,326; p = 0.041; η (2) = 0.025). Carriers of the D allele had significantly higher light physical activity (F 1,256 = 4,710; p = 0.031; η (2) = 0.20), with screen time as covariate. In conclusion, ACE gene has a significant effect on sedentary, light and total physical activity levels in healthy 12-year-old boys.

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References

Montgomery H, Clarkson P, Dollery C, Prasad K, Losi M, Hemingway H . Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training. Circulation. 1997; 96(3):741-7. DOI: 10.1161/01.cir.96.3.741. View

Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F . An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990; 86(4):1343-6. PMC: 296868. DOI: 10.1172/JCI114844. View

Tiret L, Rigat B, Visvikis S, Breda C, Corvol P, Cambien F . Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet. 1992; 51(1):197-205. PMC: 1682892. View

Freedson P, Pober D, Janz K . Calibration of accelerometer output for children. Med Sci Sports Exerc. 2005; 37(11 Suppl):S523-30. DOI: 10.1249/01.mss.0000185658.28284.ba. View

de Vilhena e Santos D, Katzmarzyk P, Seabra A, Maia J . Genetics of physical activity and physical inactivity in humans. Behav Genet. 2012; 42(4):559-78. DOI: 10.1007/s10519-012-9534-1. View

Mitchell J, Pate R, Dowda M, Mattocks C, Riddoch C, Ness A . A prospective study of sedentary behavior in a large cohort of youth. Med Sci Sports Exerc. 2011; 44(6):1081-7. PMC: 3342456. DOI: 10.1249/MSS.0b013e3182446c65. View

Ekelund U, Anderssen S, Froberg K, Sardinha L, Andersen L, Brage S . Independent associations of physical activity and cardiorespiratory fitness with metabolic risk factors in children: the European youth heart study. Diabetologia. 2007; 50(9):1832-1840. DOI: 10.1007/s00125-007-0762-5. View

Richert L, Chevalley T, Manen D, Bonjour J, Rizzoli R, Ferrari S . Bone mass in prepubertal boys is associated with a Gln223Arg amino acid substitution in the leptin receptor. J Clin Endocrinol Metab. 2007; 92(11):4380-6. DOI: 10.1210/jc.2007-0932. View

Brito E, Vimaleswaran K, Brage S, Andersen L, Sardinha L, Wareham N . PPARGC1A sequence variation and cardiovascular risk-factor levels: a study of the main genetic effects and gene x environment interactions in children from the European Youth Heart Study. Diabetologia. 2009; 52(4):609-13. DOI: 10.1007/s00125-009-1269-z. View

10.

Erdos E . Angiotensin I converting enzyme and the changes in our concepts through the years. Lewis K. Dahl memorial lecture. Hypertension. 1990; 16(4):363-70. DOI: 10.1161/01.hyp.16.4.363. View

11.

Winnicki M, Accurso V, Hoffmann M, Pawlowski R, Dorigatti F, Santonastaso M . Physical activity and angiotensin-converting enzyme gene polymorphism in mild hypertensives. Am J Med Genet A. 2004; 125A(1):38-44. DOI: 10.1002/ajmg.a.20434. View

12.

Hamilton M, Hamilton D, Zderic T . Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Diabetes. 2007; 56(11):2655-67. DOI: 10.2337/db07-0882. View

13.

Kim K . Association of angiotensin-converting enzyme insertion/deletion polymorphism with obesity, cardiovascular risk factors and exercise-mediated changes in Korean women. Eur J Appl Physiol. 2009; 105(6):879-87. DOI: 10.1007/s00421-008-0973-6. View

14.

Nader P, Bradley R, Houts R, McRitchie S, OBrien M . Moderate-to-vigorous physical activity from ages 9 to 15 years. JAMA. 2008; 300(3):295-305. DOI: 10.1001/jama.300.3.295. View

15.

Hespel P, Vergauwen L, Vandenberghe K, Richter E . Significance of insulin for glucose metabolism in skeletal muscle during contractions. Diabetes. 1996; 45 Suppl 1:S99-104. DOI: 10.2337/diab.45.1.s99. View

16.

Ruiz J, Rizzo N, Hurtig-Wennlof A, Ortega F, Warnberg J, Sjostrom M . Relations of total physical activity and intensity to fitness and fatness in children: the European Youth Heart Study. Am J Clin Nutr. 2006; 84(2):299-303. DOI: 10.1093/ajcn/84.1.299. View

17.

Martinez-Gomez D, Ruiz J, Ortega F, Casajus J, Veiga O, Widhalm K . Recommended levels and intensities of physical activity to avoid low-cardiorespiratory fitness in European adolescents: The HELENA study. Am J Hum Biol. 2010; 22(6):750-6. DOI: 10.1002/ajhb.21076. View

18.

de Moor M, Liu Y, Boomsma D, Li J, Hamilton J, Hottenga J . Genome-wide association study of exercise behavior in Dutch and American adults. Med Sci Sports Exerc. 2009; 41(10):1887-95. PMC: 2895958. DOI: 10.1249/MSS.0b013e3181a2f646. View

19.

Pate R, ONeill J, Lobelo F . The evolving definition of "sedentary". Exerc Sport Sci Rev. 2008; 36(4):173-8. DOI: 10.1097/JES.0b013e3181877d1a. View

20.

Bailey D, Fairclough S, Savory L, Denton S, Pang D, Deane C . Accelerometry-assessed sedentary behaviour and physical activity levels during the segmented school day in 10-14-year-old children: the HAPPY study. Eur J Pediatr. 2012; 171(12):1805-13. DOI: 10.1007/s00431-012-1827-0. View