Engineering Multi-stage Nanovectors for Controlled Degradation and Tunable Release Kinetics

Overview

Journal Biomaterials

Specialty Biomedical Engineering

Date 2013 Aug 6

PMID 23911070

Citations 28

Authors

Jonathan O Martinez

Ciro Chiappini

Arturas Ziemys

Ari M Faust

Milos Kojic

Xuewu Liu

Mauro Ferrari

Ennio Tasciotti

Affiliations

Soon will be listed here.

Abstract

Nanovectors hold substantial promise in abating the off-target effects of therapeutics by providing a means to selectively accumulate payloads at the target lesion, resulting in an increase in the therapeutic index. A sophisticated understanding of the factors that govern the degradation and release dynamics of these nanovectors is imperative to achieve these ambitious goals. In this work, we elucidate the relationship that exists between variations in pore size and the impact on the degradation, loading, and release of multistage nanovectors. Larger pored vectors displayed faster degradation and higher loading of nanoparticles, while exhibiting the slowest release rate. The degradation of these particles was characterized to occur in a multi-step progression where they initially decreased in size leaving the porous core isolated, while the pores gradually increased in size. Empirical loading and release studies of nanoparticles along with diffusion modeling revealed that this prolonged release was modulated by the penetration within the porous core of the vectors regulated by their pore size.

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References

Decuzzi P, Ferrari M . Design maps for nanoparticles targeting the diseased microvasculature. Biomaterials. 2007; 29(3):377-84. DOI: 10.1016/j.biomaterials.2007.09.025. View

Lee S, Ferrari M, Decuzzi P . Design of bio-mimetic particles with enhanced vascular interaction. J Biomech. 2009; 42(12):1885-90. DOI: 10.1016/j.jbiomech.2009.05.012. View

Gentile F, Curcio A, Indolfi C, Ferrari M, Decuzzi P . The margination propensity of spherical particles for vascular targeting in the microcirculation. J Nanobiotechnology. 2008; 6:9. PMC: 2563017. DOI: 10.1186/1477-3155-6-9. View

Anglin E, Schwartz M, Ng V, Perelman L, Sailor M . Engineering the chemistry and nanostructure of porous silicon Fabry-Pérot films for loading and release of a steroid. Langmuir. 2004; 20(25):11264-9. DOI: 10.1021/la048105t. View

Yoshioka T, Kawazoe N, Tateishi T, Chen G . In vitro evaluation of biodegradation of poly(lactic-co-glycolic acid) sponges. Biomaterials. 2008; 29(24-25):3438-43. DOI: 10.1016/j.biomaterials.2008.04.011. View

Archer M, Christophersen M, Fauchet P . Macroporous silicon electrical sensor for DNA hybridization detection. Biomed Microdevices. 2004; 6(3):203-11. DOI: 10.1023/B:BMMD.0000042049.85425.af. View

Schoch R, Bertsch A, Renaud P . pH-controlled diffusion of proteins with different pI values across a nanochannel on a chip. Nano Lett. 2006; 6(3):543-7. DOI: 10.1021/nl052372h. View

Salonen J, Kaukonen A, Hirvonen J, Lehto V . Mesoporous silicon in drug delivery applications. J Pharm Sci. 2007; 97(2):632-53. DOI: 10.1002/jps.20999. View

Tanaka T, Mangala L, Vivas-Mejia P, Nieves-Alicea R, Mann A, Mora E . Sustained small interfering RNA delivery by mesoporous silicon particles. Cancer Res. 2010; 70(9):3687-96. PMC: 3202607. DOI: 10.1158/0008-5472.CAN-09-3931. View

10.

Ananta J, Godin B, Sethi R, Moriggi L, Liu X, Serda R . Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast. Nat Nanotechnol. 2010; 5(11):815-21. PMC: 2974055. DOI: 10.1038/nnano.2010.203. View

11.

Fine D, Grattoni A, Hosali S, Ziemys A, De Rosa E, Gill J . A robust nanofluidic membrane with tunable zero-order release for implantable dose specific drug delivery. Lab Chip. 2010; 10(22):3074-83. DOI: 10.1039/c0lc00013b. View

12.

Tasciotti E, Liu X, Bhavane R, Plant K, Leonard A, Price B . Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. Nat Nanotechnol. 2008; 3(3):151-7. DOI: 10.1038/nnano.2008.34. View

13.

Gentile F, Ferrari M, Decuzzi P . The transport of nanoparticles in blood vessels: the effect of vessel permeability and blood rheology. Ann Biomed Eng. 2008; 36(2):254-61. DOI: 10.1007/s10439-007-9423-6. View

14.

Shen H, You J, Zhang G, Ziemys A, Li Q, Bai L . Cooperative, nanoparticle-enabled thermal therapy of breast cancer. Adv Healthc Mater. 2012; 1(1):84-9. PMC: 3842222. DOI: 10.1002/adhm.201100005. View

15.

Anglin E, Cheng L, Freeman W, Sailor M . Porous silicon in drug delivery devices and materials. Adv Drug Deliv Rev. 2008; 60(11):1266-1277. PMC: 2710886. DOI: 10.1016/j.addr.2008.03.017. View

16.

Sanhai W, Sakamoto J, Canady R, Ferrari M . Seven challenges for nanomedicine. Nat Nanotechnol. 2008; 3(5):242-4. DOI: 10.1038/nnano.2008.114. View

17.

Salonen J, Laitinen L, Kaukonen A, Tuura J, Bjorkqvist M, Heikkila T . Mesoporous silicon microparticles for oral drug delivery: loading and release of five model drugs. J Control Release. 2005; 108(2-3):362-74. DOI: 10.1016/j.jconrel.2005.08.017. View

18.

Willoughby A . Design and processing of porous materials for electronic applications. Philos Trans A Math Phys Eng Sci. 2008; 364(1838):175-87. DOI: 10.1098/rsta.2005.1694. View

19.

Gopferich A . Mechanisms of polymer degradation and erosion. Biomaterials. 1996; 17(2):103-14. DOI: 10.1016/0142-9612(96)85755-3. View

20.

Ferrari M . Nanovector therapeutics. Curr Opin Chem Biol. 2005; 9(4):343-6. DOI: 10.1016/j.cbpa.2005.06.001. View