Intravenous Magnetic Nanoparticle Cancer Hyperthermia

Overview

Journal Int J Nanomedicine

Publisher Dove Medical Press

Specialty Biotechnology

Date 2013 Aug 1

PMID 23901270

Citations 55

Authors

Hui S Huang

James F Hainfeld

Affiliations

Soon will be listed here.

Abstract

Magnetic nanoparticles heated by an alternating magnetic field could be used to treat cancers, either alone or in combination with radiotherapy or chemotherapy. However, direct intratumoral injections suffer from tumor incongruence and invasiveness, typically leaving undertreated regions, which lead to cancer regrowth. Intravenous injection more faithfully loads tumors, but, so far, it has been difficult achieving the necessary concentration in tumors before systemic toxicity occurs. Here, we describe use of a magnetic nanoparticle that, with a well-tolerated intravenous dose, achieved a tumor concentration of 1.9 mg Fe/g tumor in a subcutaneous squamous cell carcinoma mouse model, with a tumor to non-tumor ratio > 16. With an applied field of 38 kA/m at 980 kHz, tumors could be heated to 60°C in 2 minutes, durably ablating them with millimeter (mm) precision, leaving surrounding tissue intact.

Citing Articles

DDS-type near-infrared light absorber enables deeper lesion treatment in laser photothermal therapy while avoiding damage to surrounding organs.

Takahashi M, Fujishiro J, Nomura S, Harada M, Hinoki A, Arake M Front Bioeng Biotechnol. 2024; 12:1444107.

PMID: 39211012 PMC: 11357940. DOI: 10.3389/fbioe.2024.1444107.

Manipulating the Crosstalk between Cancer and Immunosuppressive Cells with Phototherapeutic Gold-Nanohut for Reprogramming Tumor Microenvironment.

Cheng H, Lee W, Hsu F, Lai Y, Huang S, Lim C Adv Sci (Weinh). 2024; 11(32):e2404347.

PMID: 38923327 PMC: 11348132. DOI: 10.1002/advs.202404347.

Toxicity testing of indocyanine green and fluorodeoxyglucose conjugated iron oxide nanoparticles with and without exposure to a magnetic field.

Unak P, Hepton R, Harper M, Yasakci V, Pearce G, Russell S Asian J Nanosci Mater. 2024; 4(3):229-239.

PMID: 38192303 PMC: 10773553. DOI: 10.26655/AJNANOMAT.2021.3.5.

Near infrared-emitting multimodal nanosystem for in vitro magnetic hyperthermia of hepatocellular carcinoma and dual imaging of in vivo liver fibrosis.

Nazeer S, Saraswathy A, Nimi N, Santhakumar H, Radhakrishnapillai Suma P, Shenoy S Sci Rep. 2023; 13(1):12947.

PMID: 37558889 PMC: 10412632. DOI: 10.1038/s41598-023-40143-3.

X-Ray Nanothermometry of Nanoparticles in Tumor-Mimicking Tissues under Photothermia.

Lopez-Mendez R, Reguera J, Fromain A, Abu Serea E, Cespedes E, Teran F Adv Healthc Mater. 2023; 12(31):e2301863.

PMID: 37463675 PMC: 11469036. DOI: 10.1002/adhm.202301863.

References

Seymour L . Passive tumor targeting of soluble macromolecules and drug conjugates. Crit Rev Ther Drug Carrier Syst. 1992; 9(2):135-87. View

Le Renard P, Jordan O, Faes A, Petri-Fink A, Hofmann H, Rufenacht D . The in vivo performance of magnetic particle-loaded injectable, in situ gelling, carriers for the delivery of local hyperthermia. Biomaterials. 2009; 31(4):691-705. DOI: 10.1016/j.biomaterials.2009.09.091. View

Kost J, Noecker R, Kunica E, Langer R . Magnetically controlled release systems: effect of polymer composition. J Biomed Mater Res. 1985; 19(8):935-40. DOI: 10.1002/jbm.820190805. View

Lee J, Jang J, Choi J, Moon S, Noh S, Kim J . Exchange-coupled magnetic nanoparticles for efficient heat induction. Nat Nanotechnol. 2011; 6(7):418-22. DOI: 10.1038/nnano.2011.95. View

Hilger I, Hergt R, Kaiser W . Use of magnetic nanoparticle heating in the treatment of breast cancer. IEE Proc Nanobiotechnol. 2006; 152(1):33-9. DOI: 10.1049/ip-nbt:20055018. View

Tanaka K, Ito A, Kobayashi T, Kawamura T, Shimada S, Matsumoto K . Heat immunotherapy using magnetic nanoparticles and dendritic cells for T-lymphoma. J Biosci Bioeng. 2005; 100(1):112-5. DOI: 10.1263/jbb.100.112. View

Danquah M, Zhang X, Mahato R . Extravasation of polymeric nanomedicines across tumor vasculature. Adv Drug Deliv Rev. 2010; 63(8):623-39. DOI: 10.1016/j.addr.2010.11.005. View

Rao W, Deng Z, Liu J . A review of hyperthermia combined with radiotherapy/chemotherapy on malignant tumors. Crit Rev Biomed Eng. 2010; 38(1):101-16. DOI: 10.1615/critrevbiomedeng.v38.i1.80. View

Peiris P, Bauer L, Toy R, Tran E, Pansky J, Doolittle E . Enhanced delivery of chemotherapy to tumors using a multicomponent nanochain with radio-frequency-tunable drug release. ACS Nano. 2012; 6(5):4157-68. PMC: 3358486. DOI: 10.1021/nn300652p. View

10.

Park J, An K, Hwang Y, Park J, Noh H, Kim J . Ultra-large-scale syntheses of monodisperse nanocrystals. Nat Mater. 2004; 3(12):891-5. DOI: 10.1038/nmat1251. View

11.

Wust P, Hildebrandt B, Sreenivasa G, Rau B, Gellermann J, Riess H . Hyperthermia in combined treatment of cancer. Lancet Oncol. 2002; 3(8):487-97. DOI: 10.1016/s1470-2045(02)00818-5. View

12.

Nomura T, Shibahara T, Katakura A, Matsubara S, Takano N . Establishment of a murine model of bone invasion by oral squamous cell carcinoma. Oral Oncol. 2006; 43(3):257-62. DOI: 10.1016/j.oraloncology.2006.03.015. View

13.

Dvorak H, Nagy J, Dvorak J, Dvorak A . Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules. Am J Pathol. 1988; 133(1):95-109. PMC: 1880651. View

14.

Rand R, Snow H, Brown W . Thermomagnetic surgery for renal cancer. Prog Clin Biol Res. 1982; 100:673-85. View

15.

Basel M, Balivada S, Wang H, Shrestha T, Seo G, Pyle M . Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model. Int J Nanomedicine. 2012; 7:297-306. PMC: 3265998. DOI: 10.2147/IJN.S28344. View

16.

Ivkov R, DeNardo S, Daum W, Foreman A, Goldstein R, Nemkov V . Application of high amplitude alternating magnetic fields for heat induction of nanoparticles localized in cancer. Clin Cancer Res. 2005; 11(19 Pt 2):7093s-7103s. DOI: 10.1158/1078-0432.CCR-1004-0016. View

17.

Suzuki M, Shinkai M, Honda H, Kobayashi T . Anticancer effect and immune induction by hyperthermia of malignant melanoma using magnetite cationic liposomes. Melanoma Res. 2003; 13(2):129-35. DOI: 10.1097/00008390-200304000-00004. View

18.

Hilger I, Andra W, Hergt R, Hiergeist R, Schubert H, Kaiser W . Electromagnetic heating of breast tumors in interventional radiology: in vitro and in vivo studies in human cadavers and mice. Radiology. 2001; 218(2):570-5. DOI: 10.1148/radiology.218.2.r01fe19570. View

19.

Masuko Y, Tazawa K, Viroonchatapan E, Takemori S, Shimizu T, Fujimaki M . Possibility of thermosensitive magnetoliposomes as a new agent for electromagnetic induced hyperthermia. Biol Pharm Bull. 1995; 18(12):1802-4. DOI: 10.1248/bpb.18.1802. View

20.

Maier-Hauff K, Ulrich F, Nestler D, Niehoff H, Wust P, Thiesen B . Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme. J Neurooncol. 2010; 103(2):317-24. PMC: 3097345. DOI: 10.1007/s11060-010-0389-0. View